Sentences with word «oxygenase»

This study is the first to demonstrate the importance of the heme oxygenase system in responding to changes in blood flow pattern and the possibility of using it to treat cardiovascular diseases, the researchers wrote.

Triterpenoid cucurbitacin E suppresses cyclo - oxygenase enzyme activity that results to anti-inflammatory effects in the body.

They identified the cytochrome p450 oxygenase CYP - 13A12 as such a factor.

From a genetic screen, we found that the cytochrome P450 oxygenase CYP - 13A12 acts in response to the EGL - 9 — HIF - 1 pathway to facilitate the O2 - ON response.

A new study in American Journal of Physiology — Heart and Circulatory Physiology identifies the involvement of a protective response pathway, the heme oxygenase system, that has potential as a new therapeutic strategy for cardiovascular diseases.

Important Safety Information: As a class, cyclo - oxygenase inhibitory NSAIDs may be associated with gastrointestinal, kidney, or liver side effects.

It does so via an increase in oxygenase - 1, the enzyme which is responsible for superoxide dismutase's production.

In the study, researchers from Mayo Clinic in Rochester, Minn., demonstrated that reducing blood flow activated the heme oxygenase genes.

And the ginkgo - protected mice behaved relatively normally following the stroke, whereas the unprotected mice and mice lacking heme oxygenase staggered and dragged their limbs.

Doré's team had discovered that mice lacking an enzyme called heme oxygenase recovered poorly from stroke.

Wehland, K. Tittmann, I. Feussner and U. Diederichsen Influence of substrate dideuteration on the reaction of the bifunctional heme enzyme Psi factor producing oxygenase A (PpoA) ChemBioChem 2011, 12, 728 - 737

Ribulose -1,5-Bis-Phosphate Carboxylase / Oxygenase Accumulation Factor1 Is Required for Holoenzyme Assembly in Maize

Patients with metastasis or disease spread can be treated with a cyclo - oxygenase inhibitor, piroxicam, or a combination of piroxicam and carboplatin chemotherapy.

Methanotrophic bacterial systems have received a great deal of attention over the last ten years since it has been found that methane mono oxygenase (the enzyme generated by Methanotrophs to react with methane) can degrade a wide variety of chlorinated hydrocarbons.

Most of the unique phytonutrients present in beets have been shown to function as anti-inflammatory compounds, largely thanks to their ability to inhibit the activity of cyclo - oxygenase enzymes.

As a class, cyclo - oxygenase inhibitory NSAIDs may be associated with gastrointestinal, kidney, or liver side effects.

Two known endogenous skin antioxidants are present in goji berries, heme oxygenase - 1 and metallothionein, which were found to be involved in the photo immune protection.

«Aspirin, with it's an anti-inflammatory properties, may reduce the risk of bile duct cancer by lessening inflammation through inhibition of an enzyme called cyclo - oxygenase (COX), which is known to promote inflammation.»

Glomus cells in the carotid bodies produce the enzymes heme oxygenase 2 (HO - 2), which generates carbon monoxide (CO) when oxygen levels are appropriate, and CSE, which generates hydrogen sulfide (H2S) when oxygen levels dip.

Further investigation of the metabolic pathway that breaks down the fluorescent material revealed a gene, heme oxygenase - 1 (HO - 1), that may be responsible for the differences in fluorescence.

Glomus cells in the carotid bodies produce the enzymes heme oxygenase 2 (HO - 2), which generates carbon monoxide (CO) when oxygen levels are appropriate, and cystathionine - γ - lyase (CSE), which generates hydrogen sulfide (H2S) when oxygen levels dip.

Increased production of the protein heme oxygenase - 1, or HO - 1, is known to help protect against endothelial cell injury and cardiovascular disease.

To figure out when the transition from healthy to unhealthy obesity occurs, Harald Esterbauer, an obesity researcher at the Medical University of Vienna, and his colleagues took a closer look at a protein called heme oxygenase - 1 (HO - 1), which was thought to suppress inflammation — the critical bridge that links obesity to metabolic disease.

Doré's team suspected that ginkgo biloba might activate heme oxygenase, thereby protecting brain cells.

Together, the two experiments suggest that ginkgo exerts a protective effect by turning on heme oxygenase.

In normal mice, ginkgo halved the volume of brain tissue injured after a stroke, but it had little effect on mutant mice that lacked heme oxygenase.

You could read her papers about myeloid - derived heme oxygenase - 1 and cancer — or you can watch her stunning ballet.

Research Interests: alcoholic liver disease; macrophages; C1q; apoptosis; fibrosis; liver disease; alcohol; Heme - oxygenase - 1; inflammation; necroptosis; high - fat diet; liver injury; fatty liver disease; complement; hepatocytes; alcoholic hepatitis; hepatic stellate cell; adiponectin; MIF; carbon tetrachloride

While heme oxygenase - 1 (HO - 1) inducers are clinically approved drugs for non-immune-related diseases, they do have immunosuppressive properties when administered systemically in rodents.

The plant carbon - fixing enzyme Rubisco (ribulose bisphosphate carboxylase / oxygenase) has poor kinetic properties with regard to its reaction with CO2, and also reacts with O2, leading to the wasteful process of photorespiration.

Pharmacological Inhibition of Host Heme Oxygenase - 1 Suppresses Mycobacterium tuberculosis Infection In Vivo by a Mechanism Dependent on T Lymphocytes.

kynurenine mono - oxygenase, an enzyme that controls the balance of harmful and protective chemicals resulting from the breakdown of proteins

Association between heme oxygenase - 1 promoter polymorphisms and the development of albuminuria in type 2 diabetes: a case - control study

Bach1 is a member of the BTB and CNC transcriptional regulator family that, like Nrf2, binds to ARE sequences as heterodimeric complexes with small Maf proteins [18] A major physiological role for Bach1 is in iron homeostasis through regulation of the expression of heme oxygenase - 1 (HMOX1), ferroportin (FPN1) and Ferritin (FTH) genes [23], [24], [33], [41].

Nrf2 binds to antioxidant response elements (AREs) found in the promoters of over 200 anti-oxidant and cytoprotective genes including NAD (P) H dehydrogenase, quinone 1 (NQO1), catalase (CAT), glutamate - cysteine ligase (GCLC), aldoketoreductase family members, thioredoxin reductase (TXNRD1), and heme oxygenase - 1 (HMOX1)[12].

Citation: Attucks OC, Jasmer KJ, Hannink M, Kassis J, Zhong Z, Gupta S, et al. (2014) Induction of Heme Oxygenase I (HMOX1) by HPP - 4382: A Novel Modulator of Bach1 Activity.

Bach1 has an endogenous ligand, heme, that inhibits Bach1 binding to ARE, thus allowing Nrf2 - mediated gene expression including that of heme - oxygenase - 1 (HMOX1), a well described target of Bach1 repression.

NSAIDs such as aspirin, ibuprofen and naproxen relieve pain and inflammation by blocking an enzyme called cyclo - oxygenase.

For example, research findings have documented the ability of betalains in Swiss chard to inhibit activity of pro-inflammatory enzymes like cyclo - oxygenase (COX) and lipoxygenase (LOX).

These benefits include the ability of betalains in Swiss chard to inhibit activity of pro-inflammatory enzymes like cyclo - oxygenase (COX) and lipoxygenase (LOX).

Non-steroidal anti-inflammatories work by interfering with specific enzymes in the body, the cyclo - oxygenase or cox enzymes.

Additionally, the purple sweet potatoes increased levels of antioxidants significantly including quinine oxidoreductase - 1, heme oxygenase - 1, and GSTα.

COX2 Inhibitors As Anti-Cancer Agents The COX2 (Cyclo - Oxygenase) pathway is upregulated in cancer, and COX2 inhibitors (celecoxib) can inhibit cell proliferation, tumor invasiveness, and angiogenesis.

The phytonutrients in beets inhibit the activity of cyclo - oxygenase enzymes (COX).

Resveratrol causes an increase in the enzyme called oxygenase 1, a mediator which triggers SOD formation.

In metabolic terms, this activity of flavonoids involves the inhibition of cyclo - oxygenase (COX) and lipoxygenase (LOX) enzymes.

Substances in fresh cucumber extracts help scavenge free radicals, help improve antioxidant status, inhibit the activity of pro-inflammatory enzymes like cyclo - oxygenase 2 (COX - 2), and prevent overproduction of nitric oxide in situations where it could pose health risks.