Sentences with phrase «p16 upregulation»
We and others have shown that the Polycomb chromatin complex represses the Ink4a / b locus in various adult stem cells and p15 / p16 upregulation during aging is linked to loss of Polycomb repression.
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Interestingly, we detected upregulation of p16 and p15 in Polycomb - null skin epithelial stem cells in young mice where it is normally detected only in aged animals.