Sentences with phrase «p16ink4a allelic variation»
Examples include the study of allelic variation in the human genome and the development of computational methods for the discovery of cancer - associated genes and diagnostic cancer markers using genomic profiles derived from different tumor types.
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In humans, disease susceptibility was mapped to a non-coding 6.1 kb 3» region of CTLA4, the common allelic variation of which was correlated with lower messenger RNA levels of the soluble alternative splice form of CTLA4.
Socio - economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene - linked polymorphic region
We examined the influence of a common allelic variation in the dopamine receptor D4 (DRD4) gene and caregiver quality on temperament in early childhood.
Allelic variation in this transporter's gene expression, regulated by a 43 bp indel in the upstream region termed 5 - HTTLPR, was initially associated with anxiety - related traits (23) and has since been investigated in many fields of serotonin - related human genetics (24).
CONCLUSIONS: These results suggest that the behavioral expression of allelic variation in MAOA activity is sensitive to social experiences early in development and that its functional outcome might depend on social context.
BACKGROUND: Allelic variation of the monoamine oxidase A (MAOA) gene has been implicated in conduct disorder and antisocial, aggressive behavior in humans when associated with early adverse experiences.
Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity
Not exact matches
He has focused on leveraging allelic expression data to quantify regulatory variation within individuals.
The variation in the ethnic composition of the urban and rural populations of the Brazilian Amazon region and of distinct regions in Brazil [26, 46], may influence the allelic and genotypic distributions reflecting in matrixes of genetic mechanisms favorable to the susceptibility to infectious and parasitic diseases, in particular to malaria.