Sentences with phrase «p53 tumor suppression»
Thus, upon activation by ActD, AKT becomes an inducer of p53 tumor suppression instead of being a survival factor, as consistently shown in human embryonic kidney cell lines (293 and 293T), human hepatoma cell line (HepG2), and mouse hepatoma cell line (Hepa - 1c1c7).
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«Most other tumors have a mutant p53, but in these testicular cell tumors, the p53 is functioning properly, and the drugs used for testicular cancer appear to work in concert with p53's tumor suppression function to kill the cancer cells.»
It can be proposed that p21 contributes to mediate p53 - dependent tumor suppression in some tumor types, which would include histiocytic sarcomas, hemangiomas, B - cell lymphomas, and lung carcinomas, but not in other tumor types, particularly spontaneous or radiation - induced T - cell lymphomas.
Our observations demonstrate that p21 contributes to tumor suppression, albeit to a lesser extent than p53.
P21 is closely related to the tumor suppressor gene P53: cancer suppression and enhanced regeneration are frequently found to be opposite sides of the same coin.
We conclude that p21 plays a significant role in tumor suppression, which is more important than that of Bax but weaker than that of p53 or its upstream regulators ATM and p19ARF.
PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K - Akt - MDM2 signaling suppression.