Sentences with phrase «p65 subunit»
NF - kB / p65 subunit DNA - interaction increase with increase of age in several tissues suggesting as NF - kB inhibition may prevent aging and its related diseases 25.
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While SIRT1 and 2 inhibit NF - kB through posttranslational modification, SIRT6 neutralizes it by decreasing the accessibility of p65 subunit on promoter region of NF - kB target genes 32.
In SIRT6 knockout mice, which exhibit accelerated aging phenotype, haploinsufficiency of p65 subunit of NF - kB resulted in improved lifespan 33.