"Pacemaker cells" refer to a special group of cells found in the heart that control the heartbeat. They generate electrical signals, or impulses, that tell the heart when to contract and pump blood. These cells are like the conductor of an orchestra, keeping the heart's rhythm in sync.
Full definition
The study, which was published in the British Journal of Pharmacology, investigated the fallopian tubes of mice and discovered that caffeine stops the actions of specialized
pacemaker cells in the wall of the tubes.
In the new research, when a spheroid of
induced pacemaker cells was surrounded by a layer of cardiac muscle cells, the IPM cells were able to drive the previously quiescent nearby cells at around 145 beats per minute.
Cho comes from Cedars - Sinai Medical Center in Los Angeles, where he specialized in understanding
cardiac pacemaker cells, a small group of muscle cells in the sinoatrial node of the heart that initiate cardiac contraction.
It uses an electrical shock to reset the electrical state of the heart so that it may beat to a rhythm controlled by its own
natural pacemaker cells.
For the scientists this is the clue that PDF clock neurons form an anatomical bridge between the
different pacemaker cells in the clock network of insects.
The circuit extends from the
master pacemaker cells called s - LNvs (red), through other cells called DN1s (orange), and on to different types of pars intercerebralis cells (blue), which modulate locomotor rhythms through the release of the molecule DH44.
At the American Heart Association Scientific Sessions meeting this week, Hee Cheol Cho's lab is presenting three abstracts
on pacemaker cells.
Cho has previously published how
induced pacemaker cells can be created by introducing the TBX18 gene into rat cardiac muscle cells.
Cho and colleagues from Cedars - Sinai recently published a paper in Stem Cell Reports describing how the gene SHOX2 can nudge embryonic stem cells into becoming
cardiac pacemaker cells.
This defect causes patients to have a disruption in bowel function, by affecting the Nav1.5 channel, a sodium channel in the gastrointestinal smooth muscle and
pacemaker cells.
When
those pacemaker cells die or stop working, the heart won't beat unless it receives an electrical shock from a pacemaker.
Cardiologist Eduardo Marbán and his colleagues realized, however, that
pacemaker cells aren't much different from other heart cells; they just have more potassium, which induces the electrical signal.
GIST tumors are derived from
the pacemaker cells that stimulate movement of the gut.