Sentences with word «paclitaxel»

Even as he leads a national clinical trial testing a combination of paclitaxel chemotherapy with an experimental agent known as efatutazone, Dr. Smallridge is working with Dr. Copland and researcher Laura Marlow to find an HDAC inhibitor that might offer additional benefit.

The results from the Moffitt study suggest that TIM -3-targeting drugs may effectively launch an immune response against cancer cells, particularly when combined with paclitaxel in breast cancer patients.

To uncover how groups of cancer cells achieve functional diversity (through RNA) to survive chemotherapy, Lopez - Diaz dosed dishes of human pre-cancer and metastatic breast cancer cells with the cancer drug paclitaxel for a week and then removed the drug for a few weeks, mimicking the treatment cycle for a cancer patient.

Gamma secretase inhibition by BMS - 906024 enhances efficacy of paclitaxel in lung adenocarcinoma.

While Paclitaxel treatment alone can lead to a decrease in tumor size, there is a large risk of relapse once the treatment is terminated.

When 2 years ago Hackett discovered a new way of using a lipid to link drugs to the soluble protein albumin, and that the combination showed promise in improving the bioavailability of the chemotherapy agent paclitaxel, he and his adviser thought they had an invention that laid the foundation for a company.

The compound (right panel) has a scorpion - like shape with two arms grabbing EphA2 - expressing cancer cells, and a tail (brown) constituted by a cytotoxic chemotherapeutic agent (paclitaxel used in this work).

Unlike regular paclitaxel, which is given intravenously over a few hours, Nanotax is given as a bolus injection, a single large dosage all at once.

Dr. Durocher adds that, «Some chemotherapy drugs such as paclitaxel work by stopping cell division.

Paclitaxel by either 1 - hour or 24 - hour infusion in combination with carboplatin in advanced non-small cell lung cancer: preliminary results comparing sequential phase II trials.

A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node - Positive or High - Risk Node - Negative HER2 - Low Invasive Breast Cancer

«Chronic Cannabinoid Receptor 2 Activation Reverses Paclitaxel Neuropathy Without Tolerance or Cannabinoid Receptor 1 — Dependent Withdrawal,» by Liting Deng et al., Biological Psychiatry, March 2015.

Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin - paclitaxel therapy.

Nanotax is the fine particle formulation of paclitaxel mixed with saline, which the body can absorb and tolerate much better without the allergy risk.

We believe our research has potential to have a major impact on paclitaxel production methods.»

«It does make it easier to get to patients sooner since paclitaxel is already on the market and we know a lot about how it works.»

Nanotax works by flipping the script on how paclitaxel is administered to patients and with how it's formulated, potentially making it a more effective and better tolerated treatment for ovarian and other abdominal cancers.

In a previous study, Shih, Wang and their colleagues found that paclitaxel resistance may occur because of higher levels of an enzyme found in ovarian cancer cells called spleen tyrosine kinase, or SYK.

A combination of fostamatinib and paclitaxel reduced tumor size in six mice by up to 87 percent, compared with no shrinkage in six untreated animals after three weeks.

After five weeks, the combination treatment in the six mice decreased tumor size by up to 66 percent, compared with six mice treated with only paclitaxel.

However, finding an alternative when supplies of paclitaxel dried up proved more challenging.

Like the family of taxanes (of which paclitaxel is a member), epothilones prevent cancer cells from dividing by interfering with tubulin proteins that form the cells» skeletal microtubules.

Adding a third drug, called bevacizumab, to the cisplatin - plus - paclitaxel cocktail further increased patient survival and is now the standard of care for patients with metastatic or recurrent carcinoma of the cervix.

Both arms received paclitaxel and carboplatin for six cycles and the study arm patients continued with bevacizumab maintenance.

This led, eventually, to a technique for releasing the drug paclitaxel into selected blood - vessel tissue, slowing the arterial blockage that causes peripheral artery disease.

First - line treatment for ovarian cancer includes surgery followed by a chemotherapy regimen combining a platinum - based (usually carboplatin) and a taxane - based (usually paclitaxel) treatment, which achieves a complete response in approximately 80 % of patients.

Cyclophosphamide, doxorubicin, and paclitaxel enhance the antigen - specific anti-tumor immune response of GM - CSF - secreting whole cell vaccines in tolerized mice.

Rieger's research showed that paclitaxel induces the degeneration of sensory nerve endings by damaging the outer layer of the skin, or epidermis.

In both cases, paclitaxel changed the tumor microenvironments in three ways, all more conducive to metastasis: The microenvironment had more of the immune cells that carry cancer cells into blood vessels, it developed blood vessels that were more permeable to cancer cells, and the tumor cells became more mobile, practically bounding into those molecular Lyfts.

A pilot study of neoadjuvant paclitaxel and radiation therapy with correlative molecular studies in Stage II / III breast cancer.

A concurrent chemotherapy and radiotherapy regimen with cisplatin and paclitaxel yielded a good response rate and strong long - term survival outcomes in patients with locally advanced or recurrent cervical cancer.

Anthelminthic drug niclosamide sensitizes the responsiveness of cervical cancer cells to paclitaxel via oxidative stress - mediated mTOR inhibition.

Despite hematologic toxicities and port - related adverse events, IP carboplatin plus IV dose - dense paclitaxel appears to be effective in patients with suboptimally debulked epithelial ovarian or primary peritoneal carcinoma.

In the case of prostate cancer, for which a chemotherapeutic agent called paclitaxel was used, the team observed an flourescence increase of 400 percent in tumors that were sensitive to the treatment.

The researchers are now testing new ways to decrease these side effects, including substituting paclitaxel (Taxol), which causes fewer side effects, for the highly toxic cisplatin.

The anticancer compound paclitaxel is refined at the Cancer Center and hailed as the most promising new anticancer drug in decades.

In collaboration with Nanyang Technological University, experiments were also conducted to co-deliver paclitaxel and small interfering RNA (siRNA) targeting a protein that prevents cell death (Bcl - 2) to MDA - MB - 231 human breast cancer cell line.

In rodents, administration of paclitaxel causes neuropathic pain that comprises of thermal hyperalgesia and mechanical allodynia, which can be reversed by different analgesic agents.

The albumin - formulation eliminated the need for an organic solvent — required for delivery of free paclitaxel — thus eliminating solvent - related side effects.

A research team at the University of California, Riverside has discovered a way for chemotherapy drug paclitaxel to target migrating, or circulating, cancer cells, which are responsible for the development of tumor metastases.

It's injected directly into the peritoneum through a catheter, which exposes the tumors to higher concentrations of the drug compared to standard IV paclitaxel treatment.

«Once this novel tumor - homing agent binds to the EphA2 receptor, the oncogene functions as a cancer - specific molecular Trojan horse for paclitaxel, carrying the drug inside the cancel cell, killing the cell, and thwarting metastasis,» said Maurizio Pellecchia, a professor of biomedical sciences at UCR's School of Medicine who led the research.

What's more, mice injected with human breast - cancer cells developed fewer aggressive tumours when treated with salinomycin compared with paclitaxel (Cell, DOI: 10.1016 / j.cell.2009.06.034).

When regular paclitaxel is given to patients, it is mixed with ethanol and castor oil derivative, and many patients develop an allergy to that additive (all patients are pretreated to prevent serious allergic reactions).