"Pain hypersensitivity" refers to a condition where a person feels more pain than usual or is extremely sensitive to pain. It means that even small or mild sensations that wouldn't normally hurt can cause them discomfort or intense pain.
Full definition
Researchers will investigate novel methods of measuring
chronic pain hypersensitivity in cats with osteoarthritis and other degenerative joint diseases to improve diagnostic and treatment strategies.
A two - year grant of $ 88,480 was awarded to Duncan Lascelles, professor of small animal surgery and pain management, to lead an investigation of novel methods to measure chronic
pain hypersensitivity in cats with osteoarthritis and other degenerative joint diseases.
Drawing from human pain genetics, an international team led by Boston Children's Hospital demonstrates a way to break the cycle
of pain hypersensitivity without the development of addiction, tolerance or side effects.
On the flip side, mice that were genetically unable to produce BH4 in their sensory nerves had
decreased pain hypersensitivity after peripheral nerve injury.
Rather than disc degeneration being the sole explanation for pain persistence, increased neural activity can manifest
as pain hypersensitivity.
The drug reduced
the pain hypersensitivity induced by the nerve injury (or accompanying inflammation) but did not affect nociceptive pain — the protective pain sensation that helps us avoid injury.
Mutations in the human gene encoding the Nav1.7 sodium channel can lead to either the inability to sense pain or
pain hypersensitivity.