The holy basil extract also affected pain in the peripheral nervous system,
where pain messages originate.
Medical device giant Medtronic has received FDA clearance for its latest non-medication pain treatment: Intellis, a system which stimulates the spinal cord with electrical impulses to block
pain messages from making it to the brain.
Using a small amount of a radioactive substance as a tracer, the scientists focused on the brain's mu - opioid system in which chemicals called endogenous opioids bind to receptors and hinder the spread
of pain messages in the brain.
A laboratory animal study published in the October 2003 issue of the «Journal of Ethnopharmacology» found that holy basil leaf extract exerted pain - relieving effects at the central nervous system level, meaning that it modulated levels of certain neurotransmitters in the brain that help
process pain messages.
This causes the release of endorphins and endogenous opiods (the body's own morphine), which help
block pain messages.
Studies show that it tamps down chemical messengers that transmit
pain messages in the brain.
When you have a tail - wagging large breed of dog, dock the tail when they are tiny so their systems aren't always
sending pain messages out to the brain.
When an opioid binds to a receptor in the peripheral nervous system, the nerve cells outside the brain, the receptor changes shape and sets in motion a cellular game of telephone that
stops pain messages from reaching the brain.
Hitting opioid receptors in the peripheral nervous system
keeps pain messages from reaching the brain.
But it's the mu receptor that is primarily responsible for opioids» analgesic effects, and drugs that fit it snugly launch a cascade of chemical changes in nerve cells that slow down the transmission
of pain messages to the spinal cord and the brain.
If your pain occurs in joints that are close to the surface of the skin (such as your hands and knees), you might find some relief from topical meds that have active ingredients such as capsaicin (which reduces your nerve cells» ability to
send pain messages), salicylates, and counterirritants like menthol and camphor, which produce hot and cold sensations.
He thinks mole rats» nerves may be wired differently to other animals, somehow stifling
the pain message.
Iannetti suggests that placing your hands in unfamiliar spatial positions relative to the body muddles the brain and disrupts the processing of
the pain message.
Reductions in substance P. mean that your brain doesn't receive
the pain messages from the part of your body that's causing you pain.
Cherries are rich in anthocyanidins, powerful flavonoids capable of blocking the enzymes responsible for sending «
pain messages» to the cells, with analgesic effects comparable to those of ibuprofen and naproxen.