These changes, say the researchers, could be down to a mismatch in the way interoceptive stimuli are integrated in
pain processing regions.
Not exact matches
But when the immune system becomes activated in response to an illness or injury, glia in
regions associated with
pain processing seem to take on another role: They release inflammatory molecules that interact with nearby neurons to amplify
pain signals.
This
region in the middle of the brain is important in
processing emotion, anticipating rewards and registering
pain.
This long trunk of nerve fibers links cortical
regions involved in fatigue,
pain, emotion and reward -
processing with the right ventral attention network, associated with cognition.
Tracey and her colleagues explored this
process by studying the connectivity between specific
regions of the
pain network.
Collectively, these findings indicate that in patients with urologic chronic pelvic
pain syndrome,
regions of the PMC are detached from the default mode network, whereas neurological
processes of self - referential thought and introspection may be joined to
pain and emotion regulatory
processes.
The left precuneus demonstrated decreased FC to several
regions of
pain processing, reward, and higher executive functioning within the prefrontal (orbitofrontal, anterior cingulate, ventromedial prefrontal) and parietal cortices (angular gyrus, superior and inferior parietal lobules).
Further investigation revealed that patients demonstrated increased FC between the PCC and several brain
regions implicated in
pain, sensory, motor, and emotion regulation
processes (eg, insular cortex, dorsolateral prefrontal cortex, thalamus, globus pallidus, putamen, amygdala, hippocampus).
Prior studies on individuals with migraine have demonstrated atrophy of the brain's cortical
regions associated with
pain processing, possibly as a result of chronic stimulation of those areas.
In comparison to controls, individuals with migraine showed reduced surface and cortical thickness area in
regions associated with
pain processing.