The eldest son of a bricklayer, Donoghue spent
several years of his Arlington, Massachusetts, childhood in a wheelchair after developing a
painful degenerative bone disease that ravaged his upper leg bones where they form the hip
joint.
The most common signs of SLE are arthritis that effects
several joints,
painful muscles, shifting lameness, skin sores and blisters, protein in the urine, decreased platelet and white blood cell count, fluctuating fevers, and immune mediated hemolytic anemia.