Sentences with phrase «pairs discordant»

But Spector argues that EpiTwin has already made valuable contributions — for example, through a study of 15 twin pairs discordant for breast cancer that pointed toward hypermethylation of the DOK7 gene, which he believes could one day be used as a biomarker to help identify women at risk for breast cancer years in advance.

Differences in methylation between monozygotic twin pairs discordant for T2D were subsequently modest.

Fourteen MZ twin pairs discordant for T2D were recruited through Scandinavian twin registries (18)(Table 1).

Our aim was to dissect molecular mechanisms underlying T2D using genome - wide expression and DNA methylation data in adipose tissue from monozygotic twin pairs discordant for T2D and independent case - control cohorts.

In this study, we capitalized on the strengths of a twin study design to present for the first time both genome - wide mRNA and DNA methylation profiles in adipose tissue from MZ twin pairs discordant for T2D.

We also identified copy number variants (CNVs) in monozygotic twin pairs discordant for T2D.

MZ twin pairs discordant for T2D are rare, and our relatively small sample size increases the risk of type II errors.

We next studied the global DNA methylation pattern with the Infinium HumanMethylation450 BeadChip in adipose tissue from 14 twin pairs discordant for T2D.

After correction for multiple testing, Ribel - Madsen et al. (13) identified two CpG sites with methylation differences of > 3 % in adipose tissue of five twin pairs discordant for T2D.

Heritability of cortical thickness changes over time in twin pairs discordant for schizophrenia

We transplanted fecal microbiota from adult female twin pairs discordant for obesity into germ - free mice fed low - fat mouse chow, as well as diets representing different levels of saturated fat and fruit and vegetable consumption typical of the U.S. diet.

Separate groups of germfree mice were colonized with uncultured fecal microbiota from each member of four twin pairs discordant for obesity or with culture collections from an obese (Ob) or lean (Ln) co-twin.

Ridaura et al. (1241214; see the Perspective by Walker and Parkhill) obtained uncultured fecal microbiota from twin pairs discordant for body mass and transplanted them into adult germ - free mice.

Unsupervised clustering proposed a large genetic contribution to the methylation variability as the affected twin from the pair discordant for T2D was epigenetically «closer» to his / her unaffected co-twin than to the other diabetic twins.

Not exact matches

The other somewhat unique feature of the study is that it included «discordant sibling pairs,» which means that one sibling was breastfed and the other was formula fed.

Researchers studied methylation, the attachment of a methyl group to specific regions of DNA, in 37 pairs of male identical twins who were discordant — meaning that one was gay and the other straight — and 10 pairs who were both gay.

In addition, cohousing coprophagic mice harboring transplanted microbiota from discordant pairs provides an opportunity to determine which bacterial taxa invade the gut communities of cage mates, how invasion correlates with host phenotypes, and how invasion and microbial niche are affected by human diets.

Such ideas inspired Tuck Ngun, a postdoc in Vilain's lab, to study the methylation patterns at 140,000 regions in the DNA of 37 pairs of male identical twins who were discordant — meaning that one was gay and the other straight — and 10 pairs who were both gay.

To test how important the five regions are, the team divided the discordant twin pairs into two groups.

Indeed, his team found the methylation of CpG sites differed in the discordant pairs with the particular genotypes of 4 polymorphisms.

Comparisons between discordant twins and individuals in case - control cohort 2 are based on paired Wilcoxon statistics.

The identification of CNVs in the discordant twins provides an additional potential explanation for phenotypic variation within MZ twin pairs.

Despite improved medications, however, some donor - recipient pairs remain incompatible because of discordant blood types or antagonistic immune systems.

If you see a moody pattern emerging on the type of films they've worked on, you'd be on the money; the pair, influenced by folks like Krzysztof Penderecki, Terry Bozzio and even later - day dark and doomy Scott Walker, traffic largely in droney and disquieting soundscapes, specializing in that sweet spot where discordant sounds subtly burn in the back of the frame rather than overpowering the narrative.

Only 21 monozygotic twin pairs out of a total of 74 monozygotic pairs, or 28 percent, were concordant for transsexualism; the remaining 72 percent of identical twins were discordant for transsexualism.

They employed a family - based discordant sib - pair analysis, which indicated that DRD4 and DAT1 failed to have significant and independent effects on ADHD.