Sentences with phrase «palbociclib induces»

However, recent observations indicate that palbociclib induces a more complete arrest than what can be achieved by blocking CDK4 / 6.

Not exact matches

«While it was known that palbociclib stalls proliferation by inhibiting CDK4 / 6, inducing proteasomal activity may be an additional mechanism that ensures the completeness of the cell cycle arrest,» says Dr. Mikael Björklund, one of the lead authors of the study.

The researchers used a novel method called thermal proteome profiling to detect cellular changes induced by palbociclib.

Proteasome activation is required for palbociclib ‐ induced cellular senescence, which is sensitive to the proteasome inhibitor bortezomib.