Sentences with phrase «palindromic repeats»

In January 2016, no less than three studies published in the journal Science and contributed by collaborative teams led by researchers at Harvard University and the Massachusetts Institute of Technology (Tabebordbar M et al. 2016), the University of Texas Southwestern Medical Center (Long C et al. 2016) and Duke University (Nelson, CE et al. 2016) reported using CRISPR (clustered regularly interspaced short palindromic repeats) / Cas9 (CRISPR - associated protein 9) genome editing approaches to permanently correct the genetic mutation in the well - known Dmdmdx mouse model for DMD (C57BL / 10ScSn - Dmdmdx / J — 001801).

Before CRISPR — an acronym for clustered regularly interspaced short palindromic repeats — there were already about 2,000 strains of mutant zebrafish.

Here we describe genome - engineering based evaluation of RNA regulatory element activity (GenERA), a clustered regularly interspaced short palindromic repeats (CRISPR)- Cas9 platform for in situ high - content functional analysis of RREs.

Fitness -, virulence - associated genome regions, and CRISPR / CAS (clustered regularly interspaced short palindromic repeats / CRISPR associated sequence) arrays of these STEC O156: H25 and O182: H25 isolates were highly similar, and identical genomic integration sites for the stx converting bacteriophages and the core LEE, identical Shiga toxin converting bacteriophage genes for stx1a, identical complete LEE loci, and identical sets of chemotaxis and flagellar genes were identified.

Ultimately this will include the expanding repertoire of advanced technologies such as clustered regularly interspaced short palindromic repeats (CRISPR), CRISPR - associated protein 9 (Cas9), and zinc - finger nucleases (ZFNs)(46) along with the new clinical indications and markets that they address.

The students are employing that technology — which includes CRISPR (clustered regularly interspaced short palindromic repeats) systems, DNA microarrays, real - time polymerase chain reactions, RNA sequencing and western blotting — to study acute myeloid leukemia (AML), which affects both children and adults and comes with a high mortality rate for older patients.

But in 2005, a search in a DNA database showed that the «clustered regularly interspaced short palindromic repeats» (or CRISPR) matched virus DNA.

Short for clustered regularly interspaced short palindromic repeats, CRISPR makes it possible for us to move genes from any living thing into another one, altering DNA for generations to come.

CRISPRs: Clustered regularly interspaced short palindromic repeats.

Clustered regularly interspaced short palindromic repeats, also known as CRISPR, evokes a sense of unease in many people, especially since the term has become synonymous to gene editing technology.

FRT sites and loxP sites differ at the nucleotide level but share an overall structure of 13 base pair palindromic repeats separated by an 8 bp asymmetric core.

One of the fastest growing areas in genome engineering is research using the powerful editing tool of clustered regularly interspaced short palindromic repeats (CRISPR).

«CRISPR» stands for «clustered regularly interspaced palindromic repeats,» first described in 1987 by Japanese researchers who found chunks of oddly repeating DNA sequences in the genome of E. coli.

This past year, scientists hijacked survival tactics of prokaryotes to deliver the technological biological blockbuster known as the CRISPR (clustered regularly interspaced palindromic repeats) Cas (CRISPR associated genes) system.

In the few short years since Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR - associated proteins (Cas) were first described, their use in editing the mouse genome has exploded.

Since it was first described in 1993, Clustered Regularly Interspaced Short Palindromic Repeats, or CRISPR, has revolutionized biomedical research.

This defense system works for Streptococcus pyogenes, using a duplex of two small RNA molecules that contain sections of the virus genome called «clustered regularly interspaced short palindromic repeats» (CRISPR), which carry the memory of a previous attack.

At its most basic, CRISPR, or Clustered Regularly Interspaced Short Palindromic Repeats, is a string of RNA.

In the frame of this call, we have added constitutive knock - out models to be generated using CRISPR (clustered regularly interspaced short palindromic repeats) genome editing technology.

The CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) system was originally discovered by dairy industry researchers seeking to prevent phages, the viruses that infect bacteria, from ruining the cultures used to make cheese and yogurt.

LoxP (locus of X (cross)- over in P1) sites are 34 - base - pair long recognition sequences consisting of two 13 - bp long palindromic repeats separated by an 8 - bp long asymmetric core spacer sequence.

Zhao and colleagues examined the ability of the CRISPR - Cas system, a set of molecules borrowed from a form of immune system in bacteria (CRISPR stands for clustered regularly interspaced short palindromic repeats, describing a feature of this system in bacterial genomes).

So I decided to test what one investigator told me: CRISPR (for «clustered regularly interspaced short palindromic repeats») may sound intimidating, but it is so simple to use that «any idiot» could do it.

To survive, the microbes deploy an adaptive nucleic acid - based immune system that revolves around a genetic element known as CRISPR, which stands for Clustered Regularly Interspaced Short Palindromic Repeats.

In addition, prokaryotes have evolved adaptive, heritable immune systems: clustered regularly interspaced palindromic repeats (CRISPR) and the CRISPR - associated proteins (CRISPR - Cas).

The CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) / Cas9 system is based on a bacterial defense mechanism.

The urinary cells were collected from patients with the chromosomal inversions causing hemophilia to make iPSCs, the team applied CRISPR - Cas9 nucleases (Clustered Regularly Interspaced Short Palindromic Repeats - CRISPR associated protein 9) to them.

Clustered regularly interspaced short palindromic repeats (CRISPR) / CRISPR - associated (Cas) systems provide bacteria and archaea with adaptive immunity against viruses and plasmids by using CRISPR RNAs (crRNAs) to guide the silencing of invading nucleic acids.

Over the past 3 years, a method called CRISPR (clustered regularly interspaced short palindromic repeats) has made editing genes a whole lot easier.

These microbes essentially keep mug shots of dangerous viruses in their DNA, storing snippets of viral genes between certain repeated segments of their own genes in a natural biological process known as CRISPR, for clustered regularly interspaced short palindromic repeats.

Looking for a mechanism, researchers found remnants of genes from past infections, sandwiched between odd, repeated bacterial DNA sequences — the «clustered regularly interspaced short palindromic repeats» that give CRISPR its name.

A new approach to clustered regularly interspaced short palindromic repeats (CRISPR), the innovative Alt - R CRISPR - Cas9 System, is based on the naturally occurring S. pyogenes CRISPR RNA system.

Most notably, researchers are eyeing CRISPR — short for the cumbersomely - named clustered regularly interspaced short palindromic repeats.

These repeating sequences have been dubbed CRISPR (or Crispr), for Clustered Regularly Interspaced Short Palindromic Repeats.

Crispr stands for Clustered Regularly Interspaced Short Palindromic Repeats.

CRISPR (an acronym for «clustered regularly interspaced short palindromic repeats») refers to bits of viral DNA that bacteria have incorporated into their own genomes.

CRISPR stands for «clustered regularly interspaced short palindromic repeats.»

(CRISPR stands for «clustered regularly interspaced short palindromic repeats.»)

Recent advances combining the gene - editing tool CRISPR — Cas9 (for, clustered, regularly interspaced, short palindromic repeats with a guiding enzyme called Cas9) are now making it easier for scientists to modify a genome such that nearly all offspring inherit the desired trait.

This protocol describes a system for efficient genome editing in hPSCs using engineered transcription activator - like effector nucleases (TALENs) or clustered regularly interspaced short palindromic repeat (CRISPR) technology.

Since 2013, the CRISPR (clustered regularly interspaced short palindromic repeat) / Cas9, which is very easy to implement, makes genome editing accessible to the whole scientific community.

Combining this with recent advances in genome editing techniques such as the clustered regularly interspaced short palindromic repeat (CRISPR) system has provided an ability to repair putative causative alleles in patient lines, or introduce disease alleles into a healthy «WT» cell line.