This is just a summary of information about praziquantel +
pyrantel pamoate + febantel.
WNT pathway inhibitor
pyrvinium pamoate inhibits the self - renewal and metastasis of breast cancer stem cells.
Pyrvinium
pamoate inhibits proliferation of myeloma / erythro - leukemia cells by suppressing mitochondrial respiratory complex I and STAT3.
It is recommended that the following drugs not be used with pyrantel
pamoate as they increase side effects potential: levamisole, morantel, or piperazine (all are other dewormers) or with organophosphate insecticides.
This is an unusual possibility but be aware of it if you are using pyrantel
pamoate in small animals.
Many of these pet store puppies have stubborn diarrheas that do not resolve with pyrantel
pamoate because that compound does not affect strongyloides and many vets miss the parasite on fecal exams.
My 8 yr old female schnauzer had an ear infection and uti at the same time, was given amoxl / clavulanate antibiotic for ten days and an allergy medicine,
hydroxyzine pamoate 25 mg.
Pyrvinium
pamoate does not activate protein kinase CK1, but promotes Akt / PKB down - regulation and GSK3 activation.
The impact of pyrvinium
pamoate on colon cancer cell viability.
Pyrvinium
pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.
Pyrantel
pamoate causes the parasite to lose grip of the intestinal wall, which makes it pass out of the system naturally.
The active ingredient pyrantel
pamoate acts as a depolarizing neuromuscular blocking agent, thereby causing sudden muscular contraction, followed by paralysis of the parasite.
If not, it should be wormed at least twice with pyrantel
pamoate before it is bred.
Ivermectin / pyrantel
pamoate administered monthly for ~ 2 yr beginning at 5 - 7 mo post-L3 inoculation eradicates most adult worms.
Heartguard Plus ® contains pyrantel
pamoate which is effective in controlling hookworms and roundworms.
On SD 0, the dogs assigned to Group 1 were treated orally with ivermectin / pyrantel
pamoate chewable tablets, Group 2 dogs were treated orally with milbemycin oxime flavored tablets, Group 3 dogs were treated with selamectin topical solution, and Group 4 dogs were treated with imidacloprid / moxidectin topical solution.
Yes, but some side effects occur more if using pyrantel
pamoate combination products at the same time as organophosphate (found in some flea and tick products) or diethylcarbamazine (once - a-day heartworm preventives) If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian Overdosing?
1 Kivipelto J, Asquith RL, Efficacy of pyrantel
pamoate against small strongyle populations.
It is a good idea to worm your kitten with pyrantel
pamoate when it is six weeks of age (or earlier if your veterinarian suspects intestinal parasites).
Roundworms and hookworms can be treated with a product containing pyrantel
pamoate such as Hartz ® UltraGuard Plus ® Rid Worm Liquid ™ for Dogs and Puppies.
This is a very unusual possibility but one should be aware of it if one is using pyrantel
pamoate in very small animals.
I don't recommend using just pyrantel
pamoate because it only covers hookworms.
Pet anxiety medications like Clomicalm and
hydroxyzine pamoate, can reduce aggressive and obsessive behaviors that often occur when pets are stressed.
An anticancer agent, pyrvinium
pamoate inhibits the NADH - fumarate reductase system - a unique mitochondrial energy metabolism in tumour microenvironments.
Anticancer activities of anthelminthics were reported for mebendazole by Mukhopadhyay et al. in 2002, for
pyrvinium pamoate (PPAM) by Esumi et al. in 2004 and for niclosamide by Wang et al. in 2009, respectively [8 - 10].
Remember that heartworms are a type of round worm and can be ridded with regular nemex or pyrantel
pamoate as usual.
General Description: Ivermectin +
pyrantel pamoate + praziquantel is a combination of 3 anti-parasitic drugs used monthly in dogs to prevent heartworm infection and for the treatment and control of tapeworms, roundworms and hookworms.
This table lists reports on investigations employing mebendazole, niclosamide and pyrvinium (
pamoate) as anticancer agents against cell lines or in experimental animal models.
Pyrvinium
pamoate (PPAM) was reported to exert its effects by inhibition of the oxidative metabolism and glucose uptake of the worms [6,7,17].
An anthelmintic drug, pyrvinium
pamoate, thwarts fibrosis and ameliorates myocardial contractile dysfunction in a mouse model of myocardial infarction.
A prominent example is the proposal to implement anthelminthics, such as mebendazole, niclosamide and pyrvinium
pamoate, as novel anticancer drugs.
This table lists reported anticancer targets of mebendazole, niclosamide and pyrvinium (
pamoate).
Antitumor activity of pyrvinium
pamoate, 6 -(dimethylamino)-2 -[2 -(2,5 - dimethyl -1-phenyl-1H-pyrrol-3-yl) ethenyl]-1-methyl-quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation.
The treatment of pinworm infections in humans (enterobiasis) with pyrvinium chloride and pyrvinium
pamoate.
Ishii I, Harada Y, Kasahara T. Reprofiling a classical anthelmintic, pyrvinium
pamoate, as an anti-cancer drug targeting mitochondrial respiration.
The substituted quinoline pyrvinium
pamoate (PPAM) is a cyanine dye which has been used to treat pinworm (Enterobius vermicularis) infections as well as strongyloidiasis in humans [5, 27].
The FDA - approved antihelminthic drug, pyrvinium
pamoate (PPAM), was found in a screening for compounds that promoted β - catenin turnover and, thereby, inhibiting Wnt signaling in ovarian and other cancer cells (Table 1)[51, 56].
In particular,
pamoate is added to pyrvinium to provide a slow release depot form of the drug [16,17].
Each Dog Worms 3 chewable tablet contains pyrantel
pamoate and praziquantel.
Heartgard Plus pet meds also contain pyrantel
pamoate to eliminate and control hookworm and roundworm infestations.
Tri-Heart Plus also contains pyrantel
pamoate to eliminate and control hookworm and roundworm infestations.
In addition Heartgard Plus for Dogs has pyrantel
pamoate to control and eliminate hookworm and roundworm infestations.
Tri-Heart Plus pet meds also contain pyrantel
pamoate to eliminate and control hookworm and roundworm infestations in dogs.
Protect your dog from heartworms with Heartgard Plus Heartgard Plus for Dogs 26 - 50 lbs, 6 Month (Green) is a monthly, heartworm preventative that also contains pyrantel
pamoate to eliminate and control hookworm and roundworm infestations.
Tri-Heart (generic Heartgard Plus) also contain pyrantel
pamoate to eliminate and control hookworm and roundworm infestations.
Heartgard Plus petmeds also contain pyrantel
pamoate to eliminate and control hookworm and roundworm infestations.
Heartgard Plus contains two active ingredients: ivermectin and pyrantel
pamoate.
It also contains pyrantel
pamoate to eliminate and control hookworm and roundworm infestations in dogs.
Pyrantel
pamoate is an anthelminthic that prevents roundworm and hookworm infections.
Tri-Heart Plus is the generic form of Heartgard and also contains pyrantel
pamoate to eliminate and control hookworm and roundworm infestations.