Also encouraging is the survival of
pancreatic islets transplanted into rats by Andrew Posselt and Ali Naji of the Hospital of the University of Pennsylvania.
Not exact matches
Using cells from cadavers, doctors have been experimentally
transplanting pancreatic islets into humans for decades, but as many as 60 percent of the
transplanted islets die immediately because they are cut off from their blood supply and are killed by an immune response due to direct injection into the bloodstream, and those that survive the
transplant usually die within several months.
Diabetes researchers are considering various replacements for insulin injections:
Transplanting new
pancreatic islet cells that make insulin, coaxing the patient's own
islets to regenerate, or treating diabetics early in the disease with immune - suppressing therapies to prevent their body from destroying the rest of their
pancreatic islets.
Faustman got her idea by chance while
transplanting islets, the
pancreatic bodies that contain beta cells, from normal mice into others that had lost theirs to type 1, or juvenile, diabetes.
This specialized procedure is performed by Jeffrey B. Matthews, MD, chairman of the Department of Surgery, and Piotr Witkowski, MD, PhD, director of the
Pancreatic and
Islet Transplant program.
The Emory
Transplant Center has conducted clinical trials since 2003
transplanting human
pancreatic islet cells into patients with Type I diabetes.
To create a lasting source of insulin - producing beta cells for
transplant, we are developing new methods to promote differentiation from
pancreatic stem cells into healthy
islets.