Sentences with phrase «pancreatic tumor tissue»

When antibodies and other methods were used to dramatically deplete the supply of Tregs in mice, the researchers saw a dramatic jump in the numbers of activated dendritic cells and CD8 + T cells in pancreatic tumor tissue, as well as a slowing of tumor growth.

Not exact matches

McDonald and close collaborators from Memorial Sloan Kettering Cancer Center and Johns Hopkins University School of Medicine sought to understand how pancreatic cancer progresses from a primary tumor in the pancreas to metastatic disease in distant tissues.

This scar tissue can serve as a protective barrier for pancreatic cancers, allowing tumors to resist chemotherapy and evade the body's own immune system.

On average, the pancreatic cancer patients examined in the study carried 15 LINE - 1 insertions in their tumor DNA that were not in healthy tissue.

Guided by a camera and the ultrasound probe, Waxman carefully positioned the endoscope over the tumor and passed a fine needle into the pancreatic lesion to sample tissue cells for biopsy.

To evaluate tumor growth in mice of each genotype, we used an orthotopic implant model derived from a spontaneous pancreatic tumor arising in a C57BL / 6 KPC mouse (33), which expresses mutant forms of K - Ras and p53 selectively in pancreatic tissue.

Bottom Line: Bacterial load was significantly higher in pancreatic tumor samples from patients with pancreatic ductal adenocarcinoma compared with pancreatic tissue from normal individuals, and in studies using mice, eliminating certain «bad» bacteria slowed the growth of pancreatic cancer, reversed immune suppression, and upregulated the immune checkpoint protein PD1.

The failure in pancreatic cancer treatment is main due to the presence of a dense and poorly vascularized stroma that increase the drug clearance in the tumors rather than the healthy tissues, decreasing drug bioavailability in the target tissue and leading to significant side effects.

A new cancer - seeking compound that can trace a pancreatic tumor's outline with exceptional clarity, then attack cancer cells while leaving healthy tissues alone, is undergoing tests at the Roswell Park Comprehensive Cancer Center's Photodynamic Therapy Center.