Previous research has shown that the signals coming from surrounding stromal cells include both supportive signals — which help
pancreatic tumors grow — and suppressive signals — which try to fight the cancer.
As
pancreatic tumors grow and evolve, they collect LINE - 1 insertions, Burns and colleagues reported in Nature Medicine in 2015.
Not exact matches
«
Pancreatic cancer cells are deadly because they program nearby immune cells to permit the
tumors to survive and
grow,» says study author George Miller, MD, head of the Cancer Immunology Program at Perlmutter and vice chair for research in the Department of Surgery at NYU Langone.
Meng and Nel also collaborated with Dr. Timothy Donahue, chief of gastrointestinal and
pancreatic surgery and a Jonsson Comprehensive Cancer Center member, to demonstrate that treatment with the iRGD peptide can enhance
tumor cell killing for patient - derived
pancreatic cancers,
growing subcutaneously in a mouse model.
Now, Salk scientists have pinned down how signals from this microenvironment encourage
pancreatic tumors to
grow by altering their metabolism.
In this study, samples were taken from patients»
tumors during surgery and transplanted into mice to
grow new
pancreatic cancer
tumors.
Experts say the length of his survival is mainly because he had a slow -
growing, rare cancer called a
pancreatic neuroendocrine islet cell
tumor.
We chose this model because 1) it more closely recapitulates features of human
pancreatic cancer than do s.c. - implanted
tumors, 2) it can be used in immunocompetent mice to permit assessment of immune responses, and 3) the cells
grow in vivo with predictable kinetics (34).
In addition, a
growing number of immunotherapy clinical trials are in place to test this groundbreaking approach on other cancers like lymphoma, multiple myeloma, and for solid
tumors, through trials in glioblastoma, mesothelioma, and ovarian and
pancreatic cancer.
Solid pseudopapillary neoplasms are slow -
growing pancreatic tumors that are usually cancerous, occurring most often in young, African - American women.