Sentences with phrase «pancreatic type cells»
San Diego, CA (March 31, 2009)-- Novocell, Inc., a stem cell engineering company, today announced that it has received U.S. Patent 7,510,876 with claims covering human definitive endoderm cells, an essential cell for generating not only pancreatic type cells, which Novocell is developing for use as a cell therapy for diabetes, but also other endoderm lineage - derived tissues and organs such as lungs, intestine, liver, thymus and thyroid.
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CRAC channels are found on many cell types, including immune cells and pancreatic acinar cells, where aberrant activation of these channels is thought to play a key role in the pathobiology of acute pancreatitis.
Stem cells have also been identified in human milk, and have the potential to differentiate into mammary epithelial lineages under mammary differentiation conditions in vitro, as well as other cell types in corresponding microenvironments, including bone cells, brain cells, liver cells, pancreatic beta cells and heart cells.
Since pancreatic cells are gone, the researchers needed a new type of cell to take over the pancreas's job.
Frequent, low - dose chemotherapy regimens avoid this effect and may therefore be more effective at treating certain types of breast and pancreatic cancer, according to the murine study «Metronomic chemotherapy prevents therapy - induced stromal activation and induction of tumor - initiating cells,» which will be published online November 23 in The Journal of Experimental Medicine.
In addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.
Another type of white blood cells — B cells or B lymphocytes — plays a major role in activating the autoreactive T cells (T lymphocytes) that then destroy the pancreatic beta cells leading to type 1 diabetes.
Pancreatic neuroendocrine tumors, often referred to as «islet cell tumors» are a type of cancer that arises from hormone - releasing cells in the pancreas.
The team believes that whichever way BMP - 7 is used, it will be less risky than other treatments for type 1 diabetes that are currently being investigated, such as those that create pancreatic cells from stem cells, or by introducing new genes into the body.
We also reactivated insulin production in human pancreatic cells from type 1 diabetes patients.»
A protein that helps bones mend also transforms pancreatic cells into insulin powerhouses — providing hope for a treatment for type 1 diabetes
«By activating the regeneration of pancreatic cells, we were able to rescue mice from late - stage type 1 and type 2 diabetes.
They've figured out how to turn human stem cells into functional pancreatic β cells — the same cells that are destroyed by the body's own immune system in type 1 diabetes patients.
Researchers have used cells that develop into sperm to create a type of pancreatic cell (blue) that secrete insulin (red), which may one day cure type 1 diabetes in men.
Researchers should be able to cultivate iPS cells into cell types they want to study — for example, dopamine neurons in the case of Parkinson's or pancreatic cells for diabetes — and find out where and how they go wrong.
In humans it could potentially treat Type 1 diabetes in early stage patients, during what is known as the «honeymoon period,» when the pancreatic beta cells have not been completely destroyed and continue to secrete insulin.
«But mounting evidence confirming angiotropism and EVMM has revolutionized the knowledge of how cancer spreads through the body to the point that other scientists have confirmed the process in other solid tumor cell types such as pancreatic cancer.»
Transplantation of pancreatic islets — cell clusters that contain insulin - producing cells — prevents severe, potentially life - threatening drops in blood sugar in people with type 1 diabetes, according to new research.
New clinical trial results show that transplantation of pancreatic islets — cell clusters that contain insulin - producing cells — prevents severe, potentially life - threatening drops in blood sugar in people with type 1 diabetes.
Protein immunoblot and histochemical analysis with antiserum to type I NO synthase suggest that the formation of NO in pancreatic B cells is catalyzed by an NADPH -(reduced form of nicotinamide adenine dinucleotide phosphate), Ca2 + / calmodulin - dependent type I NO synthase of about 150 kilodaltons.
It's believed that in type 1 diabetes, the body's immune system destroys the pancreatic beta cells responsible for making insulin, a hormone the body needs to convert food into energy.
Type 1 diabetes is an autoimmune metabolic condition in which the body kills off all the pancreatic beta cells that produce the insulin needed for glucose regulation in the body.
Zavazava's team is among several groups aiming to create an alternative source of insulin - producing pancreatic cells that can be transplanted into patients with type 1 diabetes.
People with Type 2 diabetes have an excess of a protein called islet amyloid polypeptide, or IAPP, and the accumulation of this protein is linked to the loss of insulin - producing pancreatic beta cells.
In type 1 diabetes, a person's immune system attacks and destroys the pancreatic beta cells that produce insulin.
However, both types of pancreatic cells have been extremely difficult to culture in the laboratory.
Dor's own group reports this week that its technique for tracing the origin of circulating DNA detected the expected type of cell death in people with pancreatic cancer, type 1 diabetes, multiple sclerosis, and brain injuries.
Researchers from Oregon Health and Science University have found that aspirin may slow the spread of some types of colon and pancreatic cancer cells.
Faustman got her idea by chance while transplanting islets, the pancreatic bodies that contain beta cells, from normal mice into others that had lost theirs to type 1, or juvenile, diabetes.
Around 0.4 % of newborns will develop autoimmunity to pancreatic beta cells in childhood and receive a diagnosis of type 1 diabetes before adulthood.
The 5E5 antibody recognized multiple types of cancer cells, including leukemia, ovarian, breast, and pancreatic cancer cells, but not normal tissues.
This week, he and his colleagues report a potentially significant step toward that goal: a recipe that can turn human stem cells into functional pancreatic β cells — the cells that are destroyed by the body's own immune system in type 1 diabetes patients such as Melton's son and daughter.
The combination was significantly toxic to pancreatic cancer cells and disrupted tumor growth and extended survival in several types of advanced pancreatic cancer mouse models.
In Type 1 diabetes, the immune system attacks the body, destroying pancreatic b cells and preventing the pancreas from producing the insulin.
In the original agreement, WARF gave Geron exclusive rights to develop diagnostic and treatment products in six types of stem cell - derived cell lines: pancreatic, heart muscle, nerve, blood, bone, and liver.
Furthermore, they integrated single - cell datasets of pancreatic tissue from humans and mice, thereby identifying 10 cell types that were shared across species and defining the evolutionary changes occurring in each group.
p85 also is present in insulin - producing pancreatic beta cells, and we will also see if changing the level of p85 in beta cells will make them more resilient when stressed with high insulin demands like those from early type 2 diabetes.»
Dr. Kulkarni's research focuses on investigating signaling pathways impacting growth and function of pancreatic islet cells with the long - term goal of improving therapeutic approaches for the treatment of type 1 and type 2 diabetes and obesity - associated conditions.
The PEC - Encap ™ (also known as VC - 01) product candidate is designed to deliver the same pancreatic progenitor cells in an immunoprotective device and is currently in active development as a therapy for all patients with type 1 diabetes as well as insulin requiring patients with type 2 disease.
In their new Stem Cells Translational Medicine study they show how this strategy can be safely applied to replace the pancreatic cells lost via autoimmune destruction in type 1 diabetes mellitus (T1DCells Translational Medicine study they show how this strategy can be safely applied to replace the pancreatic cells lost via autoimmune destruction in type 1 diabetes mellitus (T1Dcells lost via autoimmune destruction in type 1 diabetes mellitus (T1D)[1].
The PEC - Direct ™ product candidate delivers the pancreatic progenitor cells in a non-immunoprotective device and is being developed for type 1 diabetes patients who have severe hypoglycemic episodes, extreme glycemic lability, and / or impaired awareness of hypoglycemia.
Once implanted, the cells are designed to differentiate into the various cell types that make up the pancreatic islet, which could allow for production of insulin and other hormones, such as glucagon, needed to control blood sugar levels.
Using her mouse model, Stromnes watched as pancreatic tumors developed and noticed that one type of regulatory immune cell stood out.
She will be determining the rates and mitochondrial sites of free radical production in pancreatic beta cells, something that has not been attempted in any cell type up to this point.
FOXA1 activation, inducing enhancer reprogramming that endows a cancer cell with metastatic properties, is an epigenetic mechanism, as opposed to a genetic one, that explains at least one mechanism of metastasis in this form of pancreatic cancer, and likely, other cancer types as well.
«The second aim of the study was to see whether pancreatic insulin and enzyme secretions are controlled by different types of vagal motoneurons — the cells of the nervous system that control motor functions of the pancreas through the vagus nerve.»
Pancreatic stellate cells (PSCs) are the main cell type causing the desmoplastic reaction.
In addition to iPS cells derived from progeria - patients, the researchers successfully applied their method to adult mesenchymal stem cells, which can differentiate into a variety of cell types, including adipocytes, osteoblasts, chondrocytes, cardiomyocytes, and, as described lately, beta - pancreatic islets cells.
New research has uncovered a technique whereby tiny particles mimic the form and function of the body's pancreatic cells, an approach that is showing promise in halting the onset of type 1 diabetes.
The patch allows for the same type of therapy — using pancreatic cells to regulate insulin — but the pancreatic cells remain outside the body in the smart patch.