By performing experiments in petri dishes and with mice, they found that
panobinostat, a drug designed to change the way cells regulate genes, may be effective at
inhibiting DIPG growth and extending survival rates.
However, the team also found that a chemical called GSKJ4, which had previously been shown to
inhibit DIPG cells, worked synergistically with
panobinostat, with the two agents counteracting known mechanisms of epigenetic dysfunction in the DIPG cells.