Sentences with phrase «paper on gene»
Dr. Radislav Sedlacek and his team from the Institute of Molecular Genetics has recently published new paper on gene targeting of Rosa26 locus using TALENs.
http://www.phenogenomics.cz/ Not exact matches
In this paper, I tried to interpret evolution as a continually shifting balance, spatially and temporally, among what I called the pressures of mutation, selection, and migration on gene frequencies, in conjunction with the effects of random drift composed of random variations in these pressures and of local accidents of sampling.
We wanted to understand what types of differences are always there, what is causing them, and what they mean,» says Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory and co-senior author, with Kelly Frazer of the University of California, San Diego, on the new paper, which was published in Cell Stem Cell in April 2017.
He lamented to a graduate student that he had never heard from Prasher; then a search on a computer database turned up a recent paper by Prasher reporting the cloning of the synthetic GFP gene.
Sarah also interviews Augustine Kong of the Big Data Institute at the University of Oxford in the United Kingdom about his Science paper on the role of noninherited «nurturing genes.»
«Fascinating genetic studies had been done on SMCHD1 that linked the gene to FSHD2, a rare muscular dystrophy involving the interaction of multiple genetic sites, but it had never been connected to craniofacial abnormalities,» says Michael Talkowski, PhD, of the MGH Center for Human Genetic Research, co-senior author of the Nature Genetics paper.
Together, Meaney and Szyf have gone on to publish some two - dozen papers, finding evidence along the way of epigenetic changes to many other genes active in the brain.
Related sites Hakem and colleagues» Science paper Razqallah Hakem's home page Background on some tumor suppressor genes
«Our findings show that the gene mutation that causes Werner syndrome results in the disorganization of heterochromatin, and that this disruption of normal DNA packaging is a key driver of aging,» says Juan Carlos Izpisua Belmonte, a senior author on the paper.
The outcome of their collaboration was a joint German - language publication that appeared in 1935, called On the Nature of Gene Mutation and Gene Structure, more generally known as the Three - Man Paper.
Gene Robinson, a geneticist at the University of Illinois at Urbana - Champaign, says that the paper «opens a new line of study on the role of epigenetics in controlling reproductive conflict» in bumblebees.
«What we've determined is that this protein's ability to alter editing of mRNAs is not specific to just a few genes, but instead, its ability to bind to mRNAs is required for proper RNA editing of most mRNAs,» said Michael C. Washburn, a graduate student in the IU College of Arts and Sciences» Department of Biology and first author on the paper with Boyko Kakaradov of the University of California, San Diego.
Senior author on the paper, Deepak Srivastava, MD, director of cardiovascular and stem cell research at Gladstone and a pediatric cardiologist at the University of California San Francisco (UCSF), had previously discovered that disruption of one of two copies of a master gene called NOTCH1 can cause valve birth defects and CAVD.
«Previous techniques that have been used to investigate DNA control sequences usually rely on sorting cells one by one and measuring gene activity in each of them,» says Dr Eva Yus, lead author of the paper.
«We searched for genes that are occasionally deleted in some cancers but which are retained in cancers caused by specific tumor suppressing genes, such as PTEN,» said Di Zhao, Ph.D., Odyssey postdoctoral fellow in Cancer Biology and first author on the Nature paper.
«Our team studied thousands of molecular clues in each of these samples, sifting through extensive data on the activity of genes, proteins, and other molecules to identify those of most interest,» said Katrina Waters, the leader of the PNNL team and a corresponding author of the paper.
The paper, reported on today by Nature News, is only the second - ever publication on the ethically fraught use of gene editing in human embryos.
The teams» three papers, each on Nordic dogs (Swedish Vallhund and Norwegian Elkhound) and each addressing blinding ocular diseases affecting both dogs and people, identified genes causing retinal disease and glaucoma, which may lead to gene therapies for dogs and humans.
«The paper provides a dazzling snapshot of the process of transcription activation — the process whereby a gene is turned on in response to an instructive signal from the environment,» said Ann Hochschild, professor of microbiology and immunobiology at Harvard Medical School, who also was not part of the study.
He and his team have studied LINE - 1 and other jumping genes for years, working with colleagues from the University of Pennsylvania and the Salk Institute, who are co-authors on this paper, and, in previous studies, with colleagues at Duke University.
What's really impressive about Babar's accomplishment is that he did the work for both papers — one on the role of a population of stem cells in lung cancer development (published in Cell) the other on gene expression in group A Streptococcus (published in PNAS)-- as a participant in summer undergraduate research programs.
«Cardiovascular disease presents such a huge impact on people's lives that we should leave no stone unturned in the search for the genes that cause heart attack,» says Cristen Willer, Ph.D., the senior author of the paper and an assistant professor of Internal Medicine, Human Genetics and Computational Medicine & Bioinformatics at the U-M Medical School.
In a new paper in Nature Genetics, a team from the University of Michigan and the Norwegian University of Science and Technology report that they zeroed in on the gene in an entirely new way.
In a Cell paper published on April 7, Lanner's team analysed gene expression in 88 early human embryos and is using those data to identify genes to disrupt in embryos using CRISPR — Cas9.
By bringing together seemingly disparate disciplines, bioinformatics has united the foot soldiers of scientific research: Computer scientists find themselves sharing coffee with gene hunters, programmers sit in on molecular biology seminars, and biologists and technologists share bylines on research papers.
«This solves a long - running mystery of how a gene mutation damages the neurons that carry information from the spinal cord to our muscles, resulting in a range of sensory and movement problems,» says Samuel Pfaff, a neuroscience professor at the Salk Institute and one of the senior authors on the paper with Xiang - Lei Yang, a professor at TSRI.
Lippman and Cora MacAlister, Ph.D., lead author on the new paper, found that deleting the genes for these enzymes from the flowering mustard plant Arabidopsis thaliana and the moss Physcomitrella patens resulted in similar defects in both species, which are widely separated in evolutionary time.
In the 1974 Science paper «Acid Rain: A Serious Regional Environmental Problem,» which made «acid rain» a household term, scientist Gene Likens and his team reported on New Hampshire rain showers as acidic as lemon juice.
The Science paper, by developmental biologist Ethan Bier and his student Valentino Gantz at the University of California, San Diego, used CRISPR to insert a modification into genes on both chromosomes in a pair, so that when the flies bred, they would pass the modification on to practically all of their offspring.
The paper has split scientists, with consensus on the need for a moratorium on clinical applications but disagreement about whether to support basic research on editing genes in human sperm, eggs, or embryos.
In 2003 Sinclair's lab published a paper in Nature that described the discovery of a gene that switched on in the yeast cell in response to calorie restriction, which Sinclair calls a «master regulator in aging.»
The study is «important as a proof - of - principle,» adds human geneticist Daniel MacArthur of the Broad Institute in Cambridge, Massachusetts, who himself is on the hunt for rare genes that protect against disease and wrote a commentary accompanying the new paper.
In addition to publishing the discovery of the «speed gene» — actually a gene that controls the expression of the muscle growth factor, myostatin, in a January 2010 Public Library of Science paper — she has published research on several more genes and is seeking patents for some, including myostatin (MSTN).
«Current therapeutic approaches, which treat the symptoms of liver disease, don't stop liver fibrosis from progressing,» says Michael Downes, a senior staff scientist in the Gene Expression Laboratory and co-corresponding author on the paper.
In the PNAS paper, the scientists demonstrated their method on two genomics problems, the role of gene enhancers in the fruit fly embryo and alternative splicing in a human - derived cell line.
A: Sheltzer: Professionally, we're working on a paper together using Joan's data - analysis ability to parse through gene - expression data from more than 20,000 cancer patients.
But the message receiver can turn on the key genes and make the colors light up by pressing the nitrocellulose paper into an agar plate containing a chemical trigger that activates expression of the fluorescent proteins.
The three labs together identified several hundred human genes that influenza hijacks for its own benefit, but in most cases the groups each hit on different ones: Only about 30 genes overlap, an outcome that's «very surprising,» says Peter Palese, a virologist at Mount Sinai School of Medicine in New York City, who co-authored the paper with Chanda.
Dr Peter Rugg - Gunn, group leader in the Babraham Institute's Epigenetics research programme and a senior co-author on the paper, explains: «One of the exciting aspects of this study is that we were able to capture naïve stem cells at a very early stage of their reprogramming — these early cells had switched on a subset of naïve - specific genes, but they had not yet fully matured.
AHR2 is also the same gene identified in a 2011 Science paper by WHOI biologists and colleagues from New York University and NOAA on PCB - resistant tomcod from the Hudson River.
In the paper, the authors focus on several types of gene drives, including homing - based drives, sex - linked meiotic drives, medea and underdominance gene drives.
If a peer - reviewed paper bears out the news story, «It's one more step on the path to potential clinical application,» says bioethicist Jeffrey Kahn of Johns Hopkins University in Baltimore, Maryland, who served on a committee convened by the U.S. National Academy of Sciences (NAS) and the National Academy of Medicine in Washington, D.C., to address gene editing.
«Gene variations occur naturally, and may become common in a population if they convey a health benefit,» said Douglas Bell, Ph.D., author on the paper and researcher at the National Institute of Environmental Health Sciences (NIEHS), part of NIH.
In a 1987 Nature paper, a team led by plant geneticist Peter Meyer, then with the Max Planck Institute for Plant Breeding Research in Cologne, Germany, showed that inserting a maize gene into a petunia enabled it to produce the pigment pelargonidin and take on a salmon color.
Other results from the experiment conducted on Medaka and recently published in a PLOS ONE paper identified 11 genes involved in changes in other tissues, including the brain and intestines.
Our guest published a historic paper less than one month ago (available here), describing the first comprehensive study of an individual, combining genomic (genome sequence), transcriptomic (genes turned on / off), proteomic (the total complement of proteins - or protein profiles), metabolomic (complete metabolic analysis), and autoantibody profiles.
Political scientist Kenneth Oye, PhD, author of the Science paper and director of the MIT Program on Emerging Technologies, said the gene drives do not fit into U.S. and international regulatory frameworks.
«For example, in certain cancers, genes may be switched on at the wrong times, eventually leading to the formation of tumors,» said Brandon Razooky, a Gladstone and UCSF graduate student and the paper's other lead author.
«The extra copy of the Guy1 gene is only passed down to half of the progeny, leaving some females among the mosquitoes that did not inherit the gene in the next generation,» said Frank Criscione, who is the first author of the paper and worked on the project when he was a graduate student in the Tu laboratory.
«Precious metals are widely used in emission control, but there are always the issues of how to best utilize them and keep them stable,» said Yong Wang, Voiland distinguished professor in the Gene and Linda Voiland School of Chemical Engineering and Bioengineering and a co-author on the paper.