Sentences with phrase «parasite drug resistance»

These findings represent an important step towards a better understanding of human Leishmania infection, with relevance to parasite drug resistance, pathogenicity, and tissue tropism.

Scientists have uncovered a potential mode of parasite drug resistance in malaria infection, according to a report published in The Journal of Experimental Medicine.

Not exact matches

And the parasite that causes malaria is gaining resistance to some of the best drugs used to treat the disease, including artemisinin.

Treating malaria with chloroquine is no longer a viable option for most people as the parasite has developed resistance to the drug.

H. contortus has become resistant to all major treatments against parasitic worms, so its genome is a good model to understand how drug resistance develops in this complex group of closely related parasites and will also reveal further potential drug and vaccine targets.

Scientists have made a major breakthrough in the global search for a new drug to beat the malaria parasite's growing resistance to first - defence treatments.

Using the latest molecular biology techniques, Myrick hopes to understand drug resistance in the parasite that causes the disease.

Former mainstay drugs (chloroquine and sulfadoxine — pyrimethamine) also experienced their first resistance challenges in western Cambodia before spreading to other parts of Asia and on to Africa, where the parasites killed millions.

From the outset, a few scientists questioned whether what the group described was really drug resistance or should instead be called «slow clearance» of the parasite — and some even accused the Mahidol group of crying wolf.

Both groups confirmed in genetic, cell, and clinical studies that, for the first time, the parasite had developed resistance to both drugs used in an ACT.

Another team from the University of Washington discovered that the malaria parasite in Asia outsmarts drugs and develops resistance much more quickly than in other parts of the world.

The finding that hemozoin formation is not essential for parasite survival in reticulocytes suggests that the parasites can develop different means of survival in the blood affording them certain drug resistance.

Given the emergence of artemisinin resistance, these findings could potentially lead to the design of new treatments against drug - resistant parasites.

At AAAS, a researcher describes how treating more people for the mosquito - borne parasite could lead to more resistance to drugs

Biologists in Britain say that they have evidence that the parasite Schistosoma mansoni, which causes schistosomiasis, can develop resistance to the drug praziquantel.

We've already moved away from using quinine to treat cases as the malaria parasite has become more resistant to it, but if further drug resistance were to develop against our most valuable malaria drug, artemisinin, we would be facing a grave situation.

The current results, however, may not hold true in all areas because risk of malaria transmission varies according to location, as does parasite resistance to drugs.

By now, some parasites have evolved resistance to the drug: genetic adaptations that allow them to expel chloroquine from their food vacuoles 40 to 50 times faster than their drug - sensitive kin.

«The over-prescribing of anti-malarials puts evolutionary pressure on the malaria parasite that risks hastening its resistance to artemisinin - based combination therapy — the frontline drugs used to treat malaria in Africa,» Stoler said.

Resistance to antibiotics to tackle bacterial infections and antimicrobial drugs used to treat parasites, viruses and fungi is spreading at an alarming rate.

«Researchers assess use of drug - susceptible parasites to fight drug resistance.»

The strategy would take advantage of parasite refugia — host populations that have not been treated with drugs, thereby serving as «safe zones» where parasites don't develop drug resistance.

Growing resistance to malaria drugs in Southeast Asia is caused by a single mutated gene inside the disease - causing Plasmodium falciparum parasite, according to a study led by David Fidock, PhD, professor of microbiology & immunology and of medical sciences (in medicine) at Columbia University Medical Center.

A study published on June 25th in PLOS Pathogens reports a new way to circumvent drug resistance and lower the curative dose by delivering existing drugs directly into the parasite, a high - tech approach with potential applications to other infectious diseases.

Like for many neglected tropical diseases that disproportionately affect poor populations, existing drugs have serious side - effects and face increasing parasite resistance.

The existing drugs have serious side effects, and the parasites are developing resistance.

The findings suggest that other antimalarial medications that target maternally inherited organelles in the parasite may also have limited drug resistance.

Over the decades, malaria parasites have developed resistance to almost every drug humans have thrown at them.

This is possible because quinolines are active inside a cell organelle called the digestive vacuole; resistance occurs when the parasite finds ways of keeping the drug out of the vacuole.

Letting parasites fight could help battle drug resistance, too.

Current antimalarial drugs are becoming less effective as the parasite develops resistance to the drugs, making the search for new targets that can kill all species of malaria critical.

Genetic variation in antigenic, drug resistance, and pathogenesis determinants is abundant, consistent with an ancient origin of P. falciparum, whereas DNA variation at silent (synonymous) sites in coding sequences appears virtually absent, consistent with a recent origin of the parasite.

In the early 2000s, the malaria parasite Plasmodium falciparum developed resistance to the commonly used antimalarial drug chloroquine.

«As drug resistance is a major problem for malaria control and eradication, it is critical that that we continue to develop new antimalarials that act against previously unexploited targets in the parasite to keep priming the drug pipeline.»

Diversifying the antimalarial arsenal could also extend the lifespan of existing drugs, since relying less heavily on our most commonly used weapons gives the parasite fewer opportunities to develop resistance, Derbyshire said.

Resistance to drug treatments is spreading among the parasite's many strains, and researchers are working hard to find new drug targets.

The meeting explored the genomic epidemiology of the host, vector and parasite, highlighting the practical relevance of this research to global health, including antimalarial drug resistance, insecticide resistance, vaccine design, and mechanisms of protective immunity.

The awards span the broad mission of the NIH and include groundbreaking research, such as engineering immune cells producing drugs at the site of diseased tissue; developing a sensor to rapidly detect antibiotic resistance of a bacterial infection; understanding how certain parasites evade host detection by continually changing their surface proteins; and developing implants that run off the electricity generated from the motion of a beating the heart.

A team from the University of Melbourne has been honoured with an «Oscar of science» — the Australian Museum's annual science award, the Eureka Prize — for its work on drug resistance in malaria parasites.

A new technique has been developed to identify hotspots of malaria parasite evolution and track the rise of malarial drug resistance, faster and more efficiently than ever before.

In addition, they observed that parasites with multiple copies of the multidrug resistance gene pfmdr1 tended to be less susceptible to several drugs, including DHA.

A team from the University of Melbourne has reached the finals of the «Oscars of science» — the Australian Museum's annual science award, the Eureka Prize — for its work on drug resistance in malaria parasites.

The most comprehensive genetic study of malaria parasites in Southeast Asia has shown that resistance to antimalarial drugs was under - reported for years in Cambodia.

Topics this year include genomic epidemiology of the host, vector and parasite, highlighting the practical relevance of this research to global health, including anti-malarial drug resistance, insecticide resistance, vaccine design, and mechanisms of protective immunity.

Researchers from 23 institutions spanning South East Asia, Africa, the USA and UK sequenced parasite genomes from more than 800 malaria samples from Africa and from South East Asia, with the aim of investigating how genetic monitoring of malaria on a large scale could identify and track drug - resistance.

Using new genome sequencing technologies, the researchers discovered multiple strains of the malaria - causing parasite Plasmodium falciparum that appear to be rapidly expanding throughout the local parasite population in Western Cambodia, a known hotspot for drug resistance.

A worldwide collaboration of researchers has shown that resistance to the frontline antimalarial drug — artemisinin — can be identified by surveying the genomes of parasite populations.

Ultimately, the goals are to develop cost - effective genetic tools to determine whether a patient is carrying parasites that are drug resistant; to map the emergence of resistance; to understand the mechanisms and routes of spread of resistance; and to plan the most effective strategy to control and eliminate the problem.

«By understanding how the environment in which the parasite lives influences its susceptibility to drugs and the molecular mechanisms of drug resistance, we hope to be able to develop new intervention strategies to combat visceral leishmaniasis in Brazil.»

Each time a new antimalarial drug has been introduced, the parasites have evolved resistance to it.