Sentences with phrase «parietal endoderm»

The Venus positive population does not efficiently contribute to somatic lineages, appears at the outside of EBs, and has the capacity to colonize the visceral and parietal endoderm in chimeras.

Interestingly, while the V+S + cells did not effectively contribute to the epiblast, V+S + ES cells were found in both the visceral and parietal endoderm (Figure 8A, Table 2), suggesting that their reduced ability to contribute to the epiblast may reflect a change in potency.

In support of this idea, Beddington and Robertson originally observed ES cell contribution to all the extra-embryonic lineages, but in particular to parietal endoderm [23].

Interestingly when parietal endoderm is grafted next to epiblast, it becomes visceral and when VE is removed from epiblast it becomes parietal [58].

However, cells derived from the early epiblast are only able to contribute to embryonic lineages and not those derived from the PrEn [18]--[20], while PrEn cells can only contribute to their own lineage by colonizing the visceral and mostly parietal endoderm in chimera experiments [20]--[22].

That we have observed a direct contribution of ES cells to both visceral and parietal endoderm also has implications for canonical definitions of pluripotency.

Most strikingly when introduced back into morulae or blastocysts, the V+S + population is not effective at contributing to the epiblast and can contribute to the extra-embryonic visceral and parietal endoderm, while the V − S + population generates high contribution chimeras.

Black arrowheads show the presence of LacZ positive cells in the parietal endoderm.

Not exact matches

The epiblast is the source of all embryonic tissue and the PrEn the source of both extra-embryonic endoderm lineages, visceral and parietal.