Sentences with phrase «participants in clinical trials»

The study followed 826 participants in a clinical trial for a median of 6.5 years after they were treated with surgery and chemotherapy.

Participants in this clinical trial must be 18 years or older; have a single, recurrent Grade three or four glioma and have had prior surgery and chemoradiation.

Not exact matches

Participants in United Therapeutics» clinical trials now have their genomes sequenced and researchers at the company plan to correlate patient outcomes with that genomic sequence data.

In a clinical trial of more than 600 participants, Empliciti, when used with cancer drug Revlimid and steroid dexamethasone was better at delaying when the cancer worsened than just the two drugs alone.

The Food and Drug Administration has given Bayer's experimental blood cancer treatment copanlisib a priority review designation after the drug showed promise in fighting back follicular lymphoma in 60 % of participants in a mid-stage clinical trial.

Take the recently published results of a clinical trial that found participants who took vitamin E, believed to be neutral or beneficial in fighting cancer, had a 17 % higher risk of prostate cancer.

Dr Jaeger and Dr Wilson recruited 24 healthy, college - aged, resistance - trained participants with an average age of 21 to participate in their double - blind, placebo - controlled clinical trial.

In households where women between the ages of 15 and 40 were pregnant, volunteer participants were administered either influenza vaccine or placebo as part of a randomized, placebo - controlled Phase 4 clinical trial.

First clinical trials with a Sclerostin - inhibiting antibody developed by the companies Amgen and UCB showed promising results in that the bone mass of participants suffering from osteoporosis increased.

Investigators now are considering conducting an early - phase clinical trial in which healthy participants would consume a low - asparagine diet.

Participants in the study included 588 men diagnosed with intermediate risk prostate cancer (i.e., clinical stage T1c - T2b) and enrolled in the trial between 2003 and 2012.

The participants in the Starbrite trial bring considerable clinical and research experience.

In that older approach, trial participants worked iteratively and explicitly through target acquisition attempts while a trained clinical research technician monitored and updated the software.

In anticipation of targeted medicines, pharmaceutical and biotechnology companies are increasingly performing genetic studies of clinical trial participants in hopes of identifying genetic profiles that predict therapeutic outcomeIn anticipation of targeted medicines, pharmaceutical and biotechnology companies are increasingly performing genetic studies of clinical trial participants in hopes of identifying genetic profiles that predict therapeutic outcomein hopes of identifying genetic profiles that predict therapeutic outcomes.

All groups of both species showed improvement over the course of 10 to 12 trials, but the healthy participants consistently reached the target with a more economic route, the team reports on today in the Journal of Clinical Investigation.

Of the 10 patients enrolled in the study — a clinical trial designed to evaluate safety and feasibility — none of the participants experienced any dangerous side effects and one patient's disease remained stable after 18 months.

Last year a Monterey Calif. — based company called Ambrosia launched the first U.S. clinical trial to test the anti-aging effect of young blood in people, but participants had to pay to participate, raising ethical questions.

On September 11, the company announced the completion of a small clinical trial of its adhesive: The sealant immediately stopped blood flow after an artery - clearing operation in about 85 percent of 22 participants.

A drug used to treat men with late - stage prostate cancer proved effective in stemming progression of the disease in research participants who had not yet received chemotherapy and extended their survival, according to results from a multi-national Phase III clinical trial led by the Knight Cancer Institute at Oregon Health & Science University (OHSU).

Finally, the research team tested a drug already in clinical trials (IGF - 1) on a cohort of study participants, finding that it provoked a reversal of neural alterations, though the degree of response varied by ASD individual.

Thirty - nine randomized and quasi-randomized controlled clinical trials were included in the review, with a combined total of 4623 participants, both adults and children.

This clinical trial, which included 1,518 participants, was the basis for the recent approval from the Food and Drug Administration of a 2 - dose series of the 9 - valent HPV vaccine for adolescents,» writes Lauri E. Markowitz, M.D., of the U.S. Centers for Disease Control and Prevention, Atlanta, and colleagues in an accompanying editorial.

Michos notes that a recent randomized clinical trial published in JAMA Cardiology failed to show any cardiovascular benefit with high - doses of monthly vitamin D supplements among participants living in New Zealand.

The researchers were interested not just in how the clinical trial participants» behavior changed, but also in how these efforts affected the community as a whole, said Thomas Coates, Project Accept's overall principal investigator and director of UCLA's Center for World Health.

And up to half of participants enrolled in clinical trials to treat PTSD fail to respond to therapies including serotonin - reuptake inhibitors — a class of drugs often used as antidepressants — and cognitive behavioural therapy.

In a controlled clinical trial published in 2005 in Gastroenterology, Weinstock and his colleagues gave 52 participants with colitis 2,500 pig whipworm eggs or a placebo every two weeks for three monthIn a controlled clinical trial published in 2005 in Gastroenterology, Weinstock and his colleagues gave 52 participants with colitis 2,500 pig whipworm eggs or a placebo every two weeks for three monthin 2005 in Gastroenterology, Weinstock and his colleagues gave 52 participants with colitis 2,500 pig whipworm eggs or a placebo every two weeks for three monthin Gastroenterology, Weinstock and his colleagues gave 52 participants with colitis 2,500 pig whipworm eggs or a placebo every two weeks for three months.

UNDER PRESSURE Hitting a systolic blood pressure target of 120 millimeters of mercury took, on average, three drugs for a group of participants undergoing intensive treatment (orange line) in an NIH - sponsored clinical trial.

In a recent clinical trial on patients aged 75 and older, 90 percent of the 219 participants were able to read two lines or more on an eye chart, and 75 percent could read large - print books.

Called the high - dimensional propensity score algorithm (hd - PS), it is a tool for improving not randomized clinical trials but broader observational studies, in which researchers watch a large pool of participants and look for correlations — like the fact that wine drinkers live longer than other drinkers.

A search of the medical literature identified 122 randomized clinical trials (RCTs) and 1 cohort study (totaling 22,803 participants) that met criteria for inclusion in the analysis.

All 49 participants had been part of a previously reported clinical trial in which half of them had been randomly assigned to a tailored exercise program over a period of six months, and half had been left to their own devices.

By replicating the success of the clinical trial, the findings show that the device is as successful in the general clinical population as it was in participants that met the previous clinical trial criteria.

Study participants (n = 146; 101 males, 45 females) were enrolled in a 16 - week randomized clinical trial comparing naltrexone with placebo treatment.

Clinical trials of weight loss have been shown to improve participants» mood, but this could be a result of the supportive environment rather than the weight loss itself, as the effects are seen very early on in treatment and are not related to the extent of weight loss.

In this trial, researchers analysed data from 282 participants from five clinical sites in Belgium, Israel, Italy, the Netherlands, and the UK between 2013 and 201In this trial, researchers analysed data from 282 participants from five clinical sites in Belgium, Israel, Italy, the Netherlands, and the UK between 2013 and 201in Belgium, Israel, Italy, the Netherlands, and the UK between 2013 and 2015.

Selecting participants for Alzheimer's disease dementia or MCI trials based on the AT (N) scheme would enrich the trial with persons with the greatest likelihood of decline in the time frame of a clinical trial.

There were 595 participants in the G6 clinical trial, and information on the presence or absence of PIK3CA gene mutations was available for 512,240 with HER2 - postive breast cancer and 272 with triple - negative breast cancer.

In a presentation of early clinical trial data to the 20th Annual Scientific Meeting of the Society for Neuro - Oncology, physician scientists from the University of New Mexico Comprehensive Cancer Center reported that a large number of study participants responded well to the drug combination.

Eligible clinical trial participants receive either the navigated brain stimulation or a sham (simulated) treatment in conjunction with six weeks of hand and arm therapy provided by an occupational therapist.

In recognition of World AIDS Day on Dec. 1, UNC Health Care and our friends at StoryDrivenMedia created this video featuring HIV Cure Center researchers David Margolis, MD, and Nancie Archin, PhD, as well as clinical trial participant Rob Hill.

Although individual participants may benefit from being part of a clinical trial, participants should be aware that the primary purpose of a clinical trial is to gain new scientific knowledge so that others may be better helped in the future.

Concerningly, 20 % of publicly funded cancer clinical trials in the United States fail because investigators are unable to enroll enough participants.

Participants taking a placebo form the control group in blinded clinical trials.

blinded study - a clinical trial in which the study participant is not told whether or not he / she is receiving a study product or a placebo.

For more information regarding Bristol - Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: • Early stage IB - IIIA, operable non-small cell lung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could apply

In addition, there was no follow - up study examining the long - term outcomes of the participants of the clinical trial in RussiIn addition, there was no follow - up study examining the long - term outcomes of the participants of the clinical trial in Russiin Russia.

Seventy - five participants will receive the vaccine at WRAIR's Clinical Trial Center in Silver Spring, Md..

In this role, Ms. Roxland re-launched and chaired J&J's Ethics Committee, created an enterprise - wide consultation service for teams and individuals confronting complex research ethics issues, and provided guidance on issues such as post-trial access for former research participants, conducting clinical trials in war - torn regions, testing of a potential Ebola vaccine during a public health crisis, commercialization of stem cell therapies, subject recruitment and withdrawal, and expanded access / compassionate usIn this role, Ms. Roxland re-launched and chaired J&J's Ethics Committee, created an enterprise - wide consultation service for teams and individuals confronting complex research ethics issues, and provided guidance on issues such as post-trial access for former research participants, conducting clinical trials in war - torn regions, testing of a potential Ebola vaccine during a public health crisis, commercialization of stem cell therapies, subject recruitment and withdrawal, and expanded access / compassionate usin war - torn regions, testing of a potential Ebola vaccine during a public health crisis, commercialization of stem cell therapies, subject recruitment and withdrawal, and expanded access / compassionate use.

This paper describes results from a clinical trial that demonstrates that a single dose of a broadly neutralizing anti-HIV-1 monoclonal antibody is well tolerated and reduces viral load in a cohort of 33 research participants.

Reid and his colleagues undertook this study following the death of Jesse Gelsinger, a participant in a gene therapy clinical trial at University of Pennsylvania for ornithine transcarbanoylase (OTC) deficiency, a metabolic liver disorder.