Not exact matches
The network provides an invaluable resource for identifying targets to treat the disease and has been used to implicate a
particular signaling pathway involved in
cell motility.
In
particular, HD mutations impacting the RhoGTPase
signaling pathway interfered with filopodia, the slender projections that
cells use to direct movement and communicate with other
cells.
His lab studies a
particular signaling pathway, the RAS / RAF / MEK / ERK
pathway, which regulates
cell growth and survival in several cancers.
The Buck's Kennedy is conducting research on
cell -
signaling pathways, in
particular the mTOR
pathway, which senses cellular nutrients, oxygen and energy levels and tells
cells whether to grow, divide or stop.
Cortical development and cortical stem
cells The laboratory uses neural stem
cell culture, transgenic model systems and retroviral vectors to study
signalling pathways that are central in mouse cortical development and in
particular in cortical stem
cells.