Sentences with phrase «particular mutation»

There were large differences in the types and numbers of particular mutations found in different geographical areas.

It also brings up crucial questions for future research: Scientists still don't know how particular mutations cause cancer, why they lead to cancer in some tissues and not others, or what might be done to counteract the mutations.

With respect to antibiotic resistance, this novelty can be induced and we can trace the novelty to particular mutations arising absent gene transfer; i.e. the genes which give rise the resistance were not present prior to the mutation, they are new sequences and not simply the activation of dormant genes.

The technique scours the exome, part of the human genome that contains codes for functional proteins and can reveal particular mutations, in this case, those associated with cancer.

This hierarchical genome structure means that the impact and likelihood of particular mutations is highly context - specific, resulting in regional variation in both the susceptibility and tolerance to mutations.

A scientist would come up with a theory about how a particular mutation causes a tumor, apply for a grant, perform a study and then publish results.

To biologists, particular mutations are unpredictable.

In this respect, mutations are random — whether a particular mutation happens or not is generally unrelated to how useful that mutation would be.

Whether or not a particular mutation will increase the chance of its possessor to survive and reproduce is dependent upon a second chain of events, which is quite independent of the event of mutation itself.

The significant point is that the two causal chains are entirely independent — that is, the particular mutation and the environment at that moment.

«But the vast majority of mutations are not actionable — that is, knowing a patient has a particular mutation doesn't mean there's an available therapy that targets it.

«We looked for what no else had done and we picked this particular mutation because of its chemical properties.»

«It seems like it would be really rare and difficult for this particular mutation to occur.

VX - 770 was approved in 2012 for patients with this particular mutation, under the brand name Kalydeco.

The discovery, led by Drs. Tom Brenna, Kumar Kothapalli, and Alon Keinan provides the first evolutionary detective work that traces a higher frequency of a particular mutation to a primarily vegetarian population from Pune, India (about 70 percent), when compared to a traditional meat - eating American population, made up of mostly Kansans (less than 20 percent).

«The next step was to take this further and look at the consequences of these particular mutations,» Guziewicz said.

Of the near 8,000 families we studied, up to 140 children are likely to have these particular mutations that are responsible for their condition.

«We hope that one implication of our research is to inspire many scientists to devote their efforts to strategies that could limit the damage these particular mutations.»

Hence the prevalence of these particular mutations in certain peoples.

The scientists found West Australian starlings carrying a particular mutation in their mitochondria, the energy powerhouses of cells, almost tripled their population within five years, suggesting the mutation was beneficial to the birds on the invasion front.

What surprised the team was that this particular mutation seemed to occur at a more frequent rate than other mutations.

A particular mutation allowed one strain to take over the vat right away.

Although their particular mutation doesn't show up very often in the general population, the gene itself could play an important role in heart disease.

The reason is that you don't know which drugs are going to help with their particular mutation.

More than a decade ago, researchers discovered that individuals with an inherited sleep disorder often carry a particular mutation in a protein called PER2.

The ACMG chose those maladies because researchers know enough about them to say that these particular mutations would result in a heightened risk for specific conditions that have available treatment or management options.

Along with restoring structure and function to the p53 mutant protein, this drug compound has the ability to to activate a program that selectively kills cancer cells with this particular mutation while leaving normal cells undisturbed.

Moreover, the regional susceptibility and tolerance to a particular mutation type is a mixture of various genomic and epigenomic features and selective pressures [64].

One test checks if a particular mutation appears in a population more frequently than it does in other populations.

While most techniques identify only regions of the genome likely to contain adaptive mutations, SWIF (r) can also identify the particular mutations themselves.

Nearly half of those with primarily European Caucasian ancestry carry a particular mutation in the toll - like receptor - 1 (TLR - 1) gene that can cause excessive inflammation in joints and more frequent antibiotic - refractory arthritis.

«Because I'm interested in developing therapeutics, I need a system that generates billions of human neurons that have the particular mutations for this disease,» he says.

«Unlike most cancers that require multiple hits, we found that this particular mutation can form a tumor all by itself,» says Peter W. Lewis, an assistant professor of biomolecular chemistry in the School of Medicine and Public Health at the University of Wisconsin — Madison.

That makes it relatively simple to gauge the effectiveness of large numbers of drug candidates in treating a condition caused by a particular mutation.

By assessing the incidence of a particular mutation or the frequency at which certain genes / pathways are altered across multiple patients (of the same tumor type), it should be possible to identify key mutations.

Tessa Thompson's physicist, Josie, finds this particular mutation within herself, her skin prickling with emerging flower buds.

After examining over 300 dogs, Dr. Stern identified a mutation in the phosphatidylinositol - binding clathrin assembly protein (PICALM), a protein that is found in the canine heart, that is associated with the development of SAS in Newfoundland dogs and determined that this particular mutation is passed down to their puppies.

What is interesting and unusual about this particular mutation is that it has not been reported in any other country thus far.

So far this particular mutation has not been observed in dog breeds besides the German Shepherd, and OptiGen currently offers the ACHM2 - GS test only for this breed.

The mode of inheritance for a particular mutation determines whether there are — or are not — carriers:

The degree of risk varies in genes like this, but with this particular mutation it is very high: A dog with it is 17 times more likely to get cataracts than one that doesn't have it.

How much extra risk a particular mutation brings needs to be considered.

However, if it is otherwise a very good individual, even dogs with two copies of this particular mutation might be bred to clear - tested mates.

There is a test that is offered for Aussies but only one Aussie has been found with that particular mutation.