This particular type of tumor is fairly benign in its early stages.
He adds, «This study was actually a pilot project for a much larger effort within the Center for Molecular Therapeutics to map responses against drug combinations across hundreds of cancer cell lines, not just melanoma, and look for novel combinations that will benefit subsets of patients regardless of
the particular type of tumor they have.
They found that, in
these particular types of tumors, PLK4 regulates tumor growth and the tumor's tendency to metastasize.
Not exact matches
Although mutations can occur anywhere in the human intestine, certain
types of colorectal cancer tend to develop in
particular locations, suggesting that additional, nongenetic factors contribute to
tumor growth and dictate where polyps appear.
New technologies are coming to the fore that allow interrogation
of the
types of cells interacting with
tumors, in
particular providing intelligence on the broad variety
of complex associations between
tumor cells and the immune system.
Cancer stem cells, a
type of self - renewing cell found in
tumors, are
of particular interest because they are the main cell
type responsible for
tumor progression and for resistance to chemotherapy and radiotherapy, and therefore a major cause
of tumor recurrence after treatment.
Are they going to die or are they going to not care at all, depending upon the underlying genetics
of a
particular tumor type?
Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary
tumor samples from 26 different preclinical models and was able to compile one
of the largest databases to show which strains
of mice were best suited to study a
particular type of human breast cancer.
The screening revealed coibamide A to be capable
of killing many
types of cancer cells, but Ishmael decided to focus subsequent studies on two
types in
particular — brain
tumors, or glioblastomas, and a breast cancer subtype known as triple negative breast cancer.
However, despite this success, the use
of immunotherapy remains limited by the scarcity
of tumor - specific antigens — substances that can trigger an immune system response to a
particular type of cancer.
Tumors are notoriously heterogeneous — the product
of genetic mutations that may be common in a
particular type of cancer, or exceedingly rare.
By assessing the incidence
of a
particular mutation or the frequency at which certain genes / pathways are altered across multiple patients (
of the same
tumor type), it should be possible to identify key mutations.
«We found a strong reduction in the risk
of estrogen - receptor - negative [ER --RSB- breast cancer in
particular, which is exciting because that
type of tumor, while rarer than estrogen - receptor - positive [ER +]
tumors, tends to be aggressive.»
After irradiating the
tumor, veterinarians collect a
particular type of the dog's white blood cells, known as Natural Killer (NK) cells, then stimulate and grow the cells in a laboratory before injecting them back into the dog's
tumor.