Certain small molecules in particular have affinity for
particular types of cells.
But getting pluripotent stem cells to differentiate into
a particular type of cell that can function inside the body is not simple.
This particular type of cell - based HTS assay is used by many of the fast - track biotechs and pharmaceutical companies, and they take good care of their people.
Stem cells are cells found primarily in embryos, and they have not yet taken on the characteristics of
any particular type of cell, such as bone, muscle tissue or brain matter.
It loves
a particular type of cell in your gut.
It replicates in
a particular type of cell called a T - lymphocyte, which is responsible for regulating the immune system.
The blood work, as well as any analysis of other secretions, should show elevated levels of
a particular type of cell called an eosinophil.
Not exact matches
Recent insights into learning - oriented brain
cells called mirror neurons even hold out the possibility that someday we will have pills that will impart
particular types of skills, such as computer programming or business decision making.
The location - sharing practice does not appear to be limited to any
particular type of Android phone or tablet; Google was apparently collecting
cell tower data from all modern Android devices before being contacted by Quartz.
Embryonic
cells are pluripotent, having the full genetic code enabling them to become any
type of cell; they differentiate into
particular cells in their later development.
«When someone has a problem — whether they need to find a
particular cell line or need to understand the formulation
of a
particular type of culture medium — they're coming to you and they're in a crisis.
«The problem with plasma
cell - free liquid biopsy in
particular is that the amount
of wild -
type [DNA] can be very, very high, and so keeping that really rare signal from being swamped out by the wild -
type... is key,» says Dawne Shelton, R&D manager for in vitro diagnostic products at Bio-Rad in Hercules, California.
«Each area
of the brain is different with distinct
cell types and connectivity, so if we can confirm that one area
of circuitry is more involved in a
particular symptom than another, we may eventually be able to treat a depression patient more efficiently than treating everyone the same way.»
«We hope that these new insights will make it possible to modulate the differentiation
of stem
cells — causing them to generate
cells of a
particular type,» says Carell.
In the presence
of Acinetobacter and Akkermansia, they became a
particular type of T helper
cell, which trigger inflammation and help the immune system kill off invaders or infected
cells, the researchers report today in the Proceedings
of the National Academy
of Sciences (PNAS).
Among patients who have this
type of lung cancer, nearly one in three will carry a
particular genetic mutation on their cancer
cells.
«A personalised immunotherapy was prepared for each patient by taking a sample
of their blood and extracting a
particular type of immune
cell called dendritic
cells.
The T - lymphocytes, or T -
cells, are a
particular type of white blood corpuscle that is important to the immune system.
The volunteers, ranging in age from 20 to 88, received injections under their retina
of a
particular type of eye
cell, retinal pigment epithelium (RPE)
cells, which were derived from hESCs in the lab.
A team led by professor Massimiliano Mazzone has demonstrated that the metabolism
of macrophages, a
particular type of white blood
cell, can be attuned to prevent the spread
of cancer.
The company's goal is to create a comprehensive source
of stem
cells that could be
of particular use for treating people
of Middle Eastern descent, whose tissue
types are often underrepresented in the public tissue banks such as those in the U.S. and elsewhere.
Living in overcrowded conditions appears to protect children and young adults against developing a
particular type of Hodgkin lymphoma (HL), a cancer that originates from the lymphocytes (white blood
cells).
New technologies are coming to the fore that allow interrogation
of the
types of cells interacting with tumors, in
particular providing intelligence on the broad variety
of complex associations between tumor
cells and the immune system.
«Targeting something that is fundamental and not just a peculiarity
of a
particular cell type holds greater promise.»
Five years ago, he got the idea to test whether a
particular type of one -
celled slime mold, Physarum polycephalum, could navigate through a maze.
Adult stem
cells: They have less flexibility and «stemness» to change into different
cell types, but they can still produce new
cells, specialized to become part
of a
particular organ or tissue, such as muscle
cells or neural
cells.
While studying why some mice resist HSK, a team led by immunologist Harvey Cantor
of Harvard Medical School in Boston found that possession
of a
particular variant
of one
type of antibody renders T
cells incapable
of attacking tissue in the cornea, the transparent covering
of the iris and pupil.
Too much
of one
particular type of fat, or lipid, in a membrane shifts and turns K - Ras, shoving its active portion away from the membrane and into the
cell, where it can transmit cancer - causing signals.
Harvard School
of Public Health (HSPH) researchers have discovered that a
particular type of protein (hormone) found in fat
cells helps regulate how glucose (blood sugar) is controlled and metabolized (used for energy) in the liver.
Dogs can do that because their noses contain 900 different
types of olfactory receptors, chemical detectors in
cells that respond to many different kinds
of odor molecules in
particular ways.
Cancer stem
cells, a
type of self - renewing
cell found in tumors, are
of particular interest because they are the main
cell type responsible for tumor progression and for resistance to chemotherapy and radiotherapy, and therefore a major cause
of tumor recurrence after treatment.
«Use
of induced pluripotent stem
cell (iPSC) technology» — which involves taking skin
cells from patients and reprogramming them into embryonic - like stem
cells capable
of turning into other specific
cell types relevant for studying a
particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie
of KU Leuven.
Understanding how a
particular DNA sequence gives rise to a
particular protein provides us with some insight into that protein, but a deeper investigation
of how the protein is made, where it is located, and how much
of it is present in different
cell types is required to enable a true understanding
of its function.
In lymph nodes, a
particular type of stromal
cells that forms a scaffold for lymphocytes to crawl around within the node normally secretes an enzyme called autotaxin, which is responsible for the production
of the lipid signaling molecule, lysophosphatidic acid (LPA).
Agata Smogorzewska, head
of the Laboratory
of Genome Maintenance, wants to understand how
cells repair interstrand cross-links, a
particular type of DNA damage in which the two strands
of the double helix that normally twine about each other become physically linked.
This research reveals a new
type of cell fusion that is initiated to destroy a
particular cell, and enlightens the evolution
of sexual reproduction in flowering plants.
It's a mystery,» he said, suggesting that it could mean stem
cells thought to be committed to a
particular lineage may be capable
of becoming other
types of tissue entirely.
The screening revealed coibamide A to be capable
of killing many
types of cancer
cells, but Ishmael decided to focus subsequent studies on two
types in
particular — brain tumors, or glioblastomas, and a breast cancer subtype known as triple negative breast cancer.
«This is the first report
of a
particular normal human precursor
cell type that shows such telomere malfunction,» says Dr. Eaves.
The
cell bodies make up what is known as grey matter, brain areas where
particular types of processing happen.
In the present study, the researchers carried out a large - scale analysis
of sympathetic nerve
cells, from which they were able to demonstrate that there are many different
types of sympathetic neurons and that the different
types are associated with a
particular functions.
He adds, «This study was actually a pilot project for a much larger effort within the Center for Molecular Therapeutics to map responses against drug combinations across hundreds
of cancer
cell lines, not just melanoma, and look for novel combinations that will benefit subsets
of patients regardless
of the
particular type of tumor they have.
During a routine check
of their fourth patient last spring, the French group noted an excess
of a
particular type of T
cell.
This means keeping its activity under a
particular threshold, confining the activity to specific
cell types and properly timing the increase and decrease
of the activity levels.
A
particular type of macrophage known as microglia are found throughout the brain and spinal cord — in progressive forms
of MS, they attack the CNS, causing chronic inflammation and damage to nerve
cells.
They also found that the disruption
of the connectivity
of these
cells during brain development causes alterations in brain oscillatory activity and disturbs the function
of place
cells, a
type of pyramidal neuron that becomes active when an animal is located in a
particular place in its environment.
A
particular type of stem
cell found in muscle can give rise to new muscle tissue, so a team led by geneticist Luis Garcia
of Généthon, a nonprofit biotechnology firm in Évry, France, investigated whether these
cells could be used to reverse the dystrophin problems.
Their study in aged mice indicates that high folic acid intake causes lowered immune function because natural killer (NK)
cells, a
particular type of immune
cell, are less effective.
The research provides more evidence for how these lncRNAs, which were once thought to be a
type of «junk DNA»
of no
particular value or function, may instead play a critical role in triggering
cells to become malignant and spread.
«We were interested in the origins
of lamprey gut neurons because in other vertebrates they arise from a
particular embryonic
cell type, called neural crest
cells,» says Stephen Green, postdoctoral scholar in biology and biological engineering and co-first author on the paper.