Sentences with word «pathogenesis»
Pathogenesis refers to the process by which a disease or condition develops and progresses in the body. It involves understanding the causes and mechanisms that lead to the development of a specific illness, and the ways it affects the body's normal functioning. Full definition
He then went on to perform his graduate studies on the mechanisms of pathogenesis of Borrelia spp. causing Lyme disease in the Department of Microbiology and Immunology at the Medical College of Virginia under the supervision of Dr. Richard Marconi.
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Given its significant role in pathogenesis of cancer and cardiovascular diseases, CD47 signalling has been heavily investigated for new targeted therapeutics.
The use of molecular techniques to study microbial pathogenesis of dental diseases in dogs and cats.
Nevertheless, in toto, these results are encouraging because there is an abundance of data now that can be analyzed with existing tools and future methods to develop hypotheses on pathogenesis [9], [32].
THEMIS Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis
This work demonstrated the central role of HLA - B * 27 and HLA - B * 57 in immune control of HIV infection, and of cytotoxic T lymphocyte (CTL) escape in HIV pathogenesis (Goulder et al, AIDS Res Hum Retr, 1996; Goulder et al, Nat Med, 1997).
Mixing up principal investigators» names, expressing a lifelong interest in viral pathogenesis during an interview in a plant cell division lab, or accidentally attempting tourist - German whilst in Paris are all, in general, bad ideas.
By studying pathogenesis, Kool hopes to turn cancer into a chronic disease instead of a deadly one.
Yet he stresses that these mouse models give insights into pathogenesis and will allow for high - throughput screening of drugs and vaccines against the virus.
This proposal represents a novel translational study that targets a potential underlying pathogenesis of canine mitral valve disease.
Four of the genes are in gene families strongly associated with cancer pathogenesis (PTPRT, CDH24, PCLKC, and SLC15A1).
Christopher Basler, Ph.D., professor and director of the Center for Microbial Pathogenesis at Georgia State University, is directing the project.
C. krusei, they found, has few copies of gene families associated with pathogenesis in C. albicans, including oligopeptide transporters, aspartyl proteases, and phospholipase B genes.
There was an ancient paradigm about the «fitness cost of antibiotic resistance,» but the emergence of the new technologies of high - throughput sequencing has changed the field, allowing researchers to study bacterial pathogenesis at the genome scale,» said Dr. David Skurnik, senior author of a new Bioessays article.
Littman is the Helen L. and Martin S. Kimmel Professor of Molecular Immunology, a professor of pathology and microbiology, and a faculty member in the Molecular Pathogenesis program in the Skirball Institute for Biomedical Research at the New York University School of Medicine in New York, NY.
Dr. Garcia - Sastre directs the Icahn School of Medicine's Center for Research on Influenza Pathogenesis, one of five National Institutes of Health (NIH) Centers of Excellence for Influenza Research and Surveillance.
The study suggests that «a slow - gamma deficit might be part of this [Alzheimer's disease] pathogenesis [and that] manipulating slow - gamma activity... could be a new way to suppress amyloid - β production and increase amyloid - β clearance,» Huang added.
A periplasmic polymer curves Vibrio cholerae and promotes pathogenesis.
These results have implications for studies of dengue pathogenesis and for vaccine development, because enhancement, not just lack of protection, is of concern.
«Our findings provide new insights into SMA pathogenesis, which is crucial to developing new therapies.»
Dr. Sibley added, «Identification of important pathogenesis determinants on a genome - wide level will foster mechanistic studies on the function of key parasite virulence factors and help to improve diagnosis and treatment of toxoplasmosis.»
Pseudomonas syringae catalases are collectively required for plant pathogenesis.
Hear renowned international scientists talk about pathogenesis, host susceptibility, biomarkers, Buruli ulcers, drug resistance and participate actively by registering and submitting abstracts.
The researchers speculate that, «via disruption of endothelial barrier function in the skin, mosquito salivary gland extract may augment access of DENV to enhancing antibodies in the serum, increase the spread of infectious virus - antibody complexes, enhance infection within systemic tissues, and thus exacerbate dengue pathogenesis during ADE.»
«Besides host factors [such as low immunity to the virus in affected communities], there are definitely some other unknown viral proteins or amino acids that may contribute to the complex pathogenesis of microcephaly — independently or synergistically,» says lead author Chen - Feng Qin, chair of the Department of Virology at the Beijing Institute of Microbiology and Epidemiology.
Moreover; in addition to the various mutations that have been highlighted and interact in key component of signaling cascades, different types of RNAs have been shown to be involved in melanoma pathogenesis such as: miRNAs and lncRNAs [48, 49].
Professor Toru Miyazaki's group at the Laboratory of Molecular Biomedicine from Pathogenesis, in the Faculty of Medicine has shown that AIM (also known as CD5L) accumulates on the cell membrane of HCC cells, where it triggers the complement cascade, a highly efficient process of eliminating cancerized cells.
This microRNA — miR -124-3p — is thus a potential therapeutic target for novel drug development, and it can serve as a putative biomarker for MDD pathogenesis.
However, he said, because fungi can cause serious infections in immunocompromised individuals and are found at increased abundance in multiple disorders of the GI tract, «understanding normal fungal colonization is essential for proper treatment and prevention of fungal pathogenesis.»
They have uncovered a dual role for Tnfr2 signaling in these processes, with mesenchymal Tnfr2 driving pathogenesis and non-mesenchymal TNFR2 providing protective signals.
Current research points toward an immune mediated pathogenesis of DM.
Identified additional novel epigenetic and transcriptional regulators of cardiac hypertrophy and heart failure pathogenesis
Systems biology and bioinformatics approaches are also being applied to study Brucella pathogenesis and predict Brucella vaccine candidates.
The exact pathogenesis of canine demodicosis is unknown but is suspected to be related to an aberration in the immune system.
To go further in the TREX2 role in homeostasis and skin pathogenesis, the researchers wanted to see the role of this nuclease on psoriasis.
I have focused on a wide spectrum of transfusion - transmitted infectious diseases and immunological complications to enhance blood safety and to capitalize on the unique opportunities for natural history and pathogenesis research derived from identification of research subjects as a result of large - scale blood and plasma donor screening.
«It is remarkable that a defect caused by the influenza NS1 protein in Drosophila led to the discovery of a new role for the NS1 protein in influenza virus - induced pathogenesis,» said study coauthor Robert Krug of the University of Texas at Austin.
Response to Comment on «Oxytocin - mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring»
The first author of the paper is former Immunology and Molecular Pathogenesis graduate student Geetha Mylvaganam, PhD, now at Massachusetts General Hospital.
«New taxonomy classifies rare genetic bone disorders by metabolic pathogenesis.»
The heads of Pasteur's 12 scientific departments, to whom Skehel presented his conclusions on 17 February, are generally «very pleased,» says Brigitte Gicquel, director of the Microbial Pathogenesis department.