Sentences with word «pathophysiological»

The phenotyping department of PHENOMIN - ICS is advancing a technical platform for functional characterization of preclinical models of human diseases with respect to both genetic understanding of pathophysiological mechanisms and the assessment of drug therapies.

«The chronic exposure to high levels of ROS is associated with the development and / or progression of pathophysiological processes, and implicated in an increasing number of human diseases, such as cardiovascular, metabolic, inflammatory and neurogenerative diseases, cancer as well as muscle atrophy and the ageing process.»

This enables us now to in depth analyse pathophysiological changes.

We present the literature on pathophysiological processes that may hasten aging and its relevance to addiction, including: oxidative stress and cellular aging, inflammation...

Chronic stress leads to a dysregulation of the hypothalamic - pituitary - adrenal (HPA) axis which can constitute a base for pathophysiological consequences.

These mechanisms have significant relevance in ovarian cancers and stress response, pathophysiological conditions in which miR - 200c / 141 exert key functions (Batista, Nature Communications, 2016).

The cellular model of the airway mucosa could provide insight into biological and pathophysiological effects that conventional cell cultures or animal models do not capture, and help lead to the development of new therapeutics.

Antibody microarrays are powerful tools for simultaneous detection of hundreds or thousands of blood - borne protein biomarkers at once, potentially allowing accurate fingerprinting and improved diagnostics of complex pathophysiological states such as cancers, neurodegenerative diseases and autoimmune conditions.

We are investigating both the normal physiological control and pathophysiological alterations of these functions.

Functional studies in rodent models suggest that OPHN1 linked ID is a consequence of abnormal synaptic transmission and shares common pathophysiological mechanisms with other cognitive disorders.

For example, some common pathophysiological pathways, such as hyperandrogenism or insulin resistance, may be involved.

Research in our laboratory focuses on the biological and pathophysiological functions of apolipoprotein (apo) E. Long - term goals of our research are to understand the molecular and cellular mechanisms by which apoE4 increases the risk of Alzheimer's disease (AD) and related neurodegeneratative disorders and to develop therapeutic strategies to treat or prevent AD.

Lipids play essential structural roles, act as nutrients, and control a broad range of physiological and pathophysiological events in cells, according to the researchers.

Due to its design, the study could not shed light on pathophysiological factors causing sex differences in atrial fibrillation risk.

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

The data demonstrate the role of myocardial Gq in the initiation of myocardial hypertrophy and indicate a possible strategy for preventing pathophysiological signaling by simultaneously blocking multiple receptors coupled to Gq.

Cardiac arrhythmias are cardiomyopathies that regroup different pathophysiological syndromes such as atrial fibrillation, tachycardia and ventricular fibrillation.

«Twin expression profiling identifies cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled Rheumatoid Arthritis»

Aidinis V. Carninci P., Armaka M., Witke W., Harokopos V., Pavelka N., Koczan D., Argyropoulos C., Thwin M., Möller S., Gopalakrishnakone P., Ricciardi - Castagnoli P., Thiesen H.J., Hayashizaki Y. and Kollias G.,, 2005, «Twin expression profiling identifies cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled Rheumatoid Arthritis», PLoS Genetics, (Vol 1 (4), e48 [PubMed].

Our conjecture is that these patients» symptoms and signs result from pathophysiological processes not related directly to thyroid hormone.

Her research interests involve metabolic and pathophysiological differences in the onset of obesity in African - American and Caucasian - American women.

Because the underlying mechanism is unclear, the authors speculated different pathophysiological causes for these sex differences in β - cell function in mothers.

Project: Pathophysiological Progression in Single RGC Axons Following Microscale Compressive Injury

«Our study demonstrates the importance of membrane trafficking in neuronal development and it provides a new pathophysiological mechanism for this disease type.

«For example, it is conceivable to deep - freeze a human tumor immediately after surgical removal and to precisely determine its biological and pathophysiological profile with the new method,» explains Pichler.

«The next step in understanding sleep apnea in the future will be to dissect different subtypes of sleep apnea, likely defined by distinct pathophysiological mechanisms which may underlie different outcomes and predisposition to comorbidities,» Cavadas says, «As human life expectancy increases, delaying the onset of age - related diseases becomes critical to our society.»

This large - scale epileptic network comprises various areas of the brain involved in normal brain activity during both seizure - free intervals and those involved in so - called pathophysiological activities such as seizures.

Describe how protein profile comparisons of Alzheimer's disease and multiple sclerosis reveal important pathophysiological and mechanistic insights

The relevance to account for the major pathophysiological mechanisms of diabetes can be observed that in diabetes diagnosed by elevated fasting or 2 hr glucose levels during a standard oral glucose tolerance test (OGTT) the prevalence and the sequence of appearance of impaired insulin production and impaired insulin secretion differ.

Among scientists it is well established that several pathophysiological mechanisms are involved in the development of type 2 diabetes.

Diagnosis, pathophysiological findings, evaluation, treatment and prevention are outlined in a recent review of the literature published online today by the Journal of the American Medical Association Pediatrics (JAMA Pediatrics).

Evaluation of these in phenotypic assays has the potential to discover important pathways or targets connected to key pathophysiological processes.

More research regarding sex - dimorphic pathophysiological mechanisms of T2DM and its complications could contribute to more personalized diabetes care in the future and would thus promote more awareness in terms of sex - and gender - specific risk factors.

Beta cell function exhibits enormous plasticity in response to various physiological and pathophysiological situations.

The challenge for the years to come is to convert data on new genes, gene defects and human genome variation in patients with genetic cardiovascular disease into functionally relevant information on the diverse pathophysiological mechanisms and clinical manifestations.

Important physiological and pathophysiological sex differences of anthropometric, metabolic, and endocrine parameters are summarized in Figure 3.

Studies highlighting sex dimorphism and exploring pathophysiological mechanisms in animal models or humans are widely missing.

Quantitative measurements of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification

Direct conversion or reprogramming of human postnatal cells into endothelial cells (ECs), bypassing stem or progenitor cell status, is crucial for regenerative medicine, cell therapy, and pathophysiological investigation but has remained largely unexplored.

The two main pathophysiological mechanisms of diabetes (beta cell function and insulin sensitivity) improved at the same time from a single dietary intervention.

Conditionally essential amino acids are those that have limited synthesis by the body when under special pathophysiological conditions, like stress.