Sentences with phrase «pathway in human disease»

«We hope that the results from this study will enable investigators to test the relevance of the maresin pathway in human disease,» said Charles N. Serhan, Ph.D., a researcher involved in the work from the Brigham & Women's Hospital and Harvard Medical School in Boston, Mass. «Moreover, we hope to better understand resolution biology and its potential pharmacology so that we can enhance our ability to control unwanted inflammation and improve the quality of life.»

Not exact matches

The inhibition of this signaling pathway by NT219 protected worms from toxic protein aggregation that in humans is associated with the development of Alzheimer's or Huntington's disease.

«The ultrasensitive detection of interferon - protein in human material can provide novel insights into disease - causing pathways,» explains co-senior author Duffy.

«ELITE provides proof of concept and first direct evidence from human investigation that timing of hormone therapy is imperative for success in the prevention of atherosclerosis progression, the primary underlying pathway that leads to heart disease and stroke,» Hodis added.

Dartmouth researchers developed a new biological pathway - based computational model, called the Pathway - based Human Phenotype Network (PHPN), to identify underlying genetic connections between different diseases as reported in BioDataMining thipathway - based computational model, called the Pathway - based Human Phenotype Network (PHPN), to identify underlying genetic connections between different diseases as reported in BioDataMining thiPathway - based Human Phenotype Network (PHPN), to identify underlying genetic connections between different diseases as reported in BioDataMining this week.

Thinking they may have hit upon a useful gene that could reveal disease pathways, his group searched to see if the mouse mutation could also be found in schizophrenic humans.

The Wnt pathway is found throughout the animal kingdom — from sponges to humans — and it plays a fundamental role in animal development and disease.

«The capability of this method to separate exosomes without altering their biological or physical characteristics potentially offers new pathways to assess human health as well as the onset and progression of diseases,» said Subra Suresh, co-corresponding author of the paper and president - designate of Nanyang Technological University Singapore, the 21st Century Professor of Biomechanics in Medicine at the University of Pittsburgh Medical School, and former president of Carnegie Mellon University.

Because myostatin normally acts to limit muscle growth, there has been considerable interest in targeting this pathway to attempt to enhance muscle growth in human patients with muscle wasting and muscle degenerative diseases.

The use of NHP in biomedical research is justified in the studies of human diseases, to learn more about their causal pathways, their development, their infectiveness and to develop therapeutic and preventive strategies.

In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 201in 2019.

She is registred to the National Order of Biologists in the province of Palermo; collaboration in research project from 2012 to 2015 at the Department of Biopathology and Biotechnology, University of Palermo, focusing the study on the identification of molecules capable to modulate intracellular metabolic pathways for the prevention and treatment of infectious, tumor and degenerative disease, in collaboration with Prof. Angela Santoni, University of Rome; collaboration in research project in 2011 at the hospital «Villa Sofia Cervello» of Palermo to study methods can cure the genetic defect that causes thalassemia through genetic engineering; she studies different mechanisms of the differentiation and the activation of human gammadelta T cells as effector cells of the immune response against cancer and infectious diseases; she investigates about the identification and development of biomarkers of resistance and susceptibility to Mycobacterium tuberculosis infection; Valentina Orlando has published 13 papers in peer reviewed journals and 3 comunications at national and international congress.

The revolution in human genetics has revealed a large number of genes and pathways associated with these diseases, and emerging methodologies are starting to systematically analyze the cellular and molecular circuitry underlying disease.

«This study reveals new pathways in the earliest stages of ALS - FTD and opens the way for developing new classes of drugs to combat this dreadful disease,» says study author Justin Fallon, PhD, a professor of medical science and of psychiatry and human behavior, and a researcher at the Brown Institute for Brain Science.

Moreover, PHENONIM - ICS is involved in European projects presenting a strong impact on human health: Interreg CARDIOGENE (Genetic mechanisms of cardiovascular diseases), GENCODYS (Genetic and epigenetic networks involved in cognitive dysfunctions), AgedBrainSYSBIO (Basic studies of brain aging), as well as projects in partnership with industry: MAGenTA (an Industrial Strategic Innovation project supported by Bpifrance about the treatment of major urogenital diseases) and CanPathPro (H2020 program), to develop a predictive modeling platform of signaling pathways involved in cancers.

Molecular understanding of the genes and pathways that modify blood lipid levels in humans will facilitate the design of new therapies for cardiovascular and metabolic disease.

Potential projects include identifying common pathways that modify retinal degenerative disease from a large collection of actively maintained mouse models; determining molecular networks implicated in pathological disruption of the retinal pigment epithelium; identifying molecular pathways that regulate postnatal ocular growth; and using mouse models to assess the pathogenic role of gene variants that increase the risk of age - related macular degeneration as identified by human genome - wide association studies.

• In nutrigenomics, the basic goal is to discover how diet affects metabolic pathways in the body and how this regulation may be disturbed in diet - related disease — i.e., humans with a certain mutated gene absorb higher levels of fat from the intestine, leading to elevated cholesterol and possible atherosclerosiIn nutrigenomics, the basic goal is to discover how diet affects metabolic pathways in the body and how this regulation may be disturbed in diet - related disease — i.e., humans with a certain mutated gene absorb higher levels of fat from the intestine, leading to elevated cholesterol and possible atherosclerosiin the body and how this regulation may be disturbed in diet - related disease — i.e., humans with a certain mutated gene absorb higher levels of fat from the intestine, leading to elevated cholesterol and possible atherosclerosiin diet - related disease — i.e., humans with a certain mutated gene absorb higher levels of fat from the intestine, leading to elevated cholesterol and possible atherosclerosis.

Dr. Sawyer's more recent work in prostate cancer has defined critical signaling pathways for disease initiation and progression through studies in mouse models and human tissues.

The Ellerby lab is known for its pioneering studies on Huntington's disease (HD), and Karen is now using human stem cell models of HD to understand why important molecular signaling pathways, such as the TGF - β pathway, are dysregulated in HD.

Many of these pathways are shared with humans and are affected in various disease conditions, suggesting constraint in the genetic pathways that can lead to change in adult form.

The white matter pathways comprise a set of active wires and the responses and properties of these wires predict human cognitive and emotional abilities in health and disease.

The authors of the study explain that their findings suggest that ketogenic diets could also potentially help normalize pathological behaviors in the human model of schizophrenia by providing alternative energy sources via ketones, the products of fat breakdown, which would substitute the abnormally functioning cellular energy pathways in the brains of people suffering from this disease.