Sentences with phrase «pathways in the cancer cells»

Recent findings from the University of Texas MD Anderson Cancer Center suggests that capsaicin, the active chemical compound that gives chile peppers their heat, may reduce and even block chronic inflammation pathways in cancer cells.

Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered a signaling pathway in cancer cells that controls their ability to invade nearby tissues in a finely orchestrated manner.

Researchers used the new therapy to inhibit a pathway in the cancer cells known as mTOR signaling — putting the brakes on this pathway, combined with the current standard therapy, caused more of the cancer cells to die.

However, the finding is also interesting from a therapeutic standpoint since there are many drug - like molecules that can be used to turn on and off the AMPK controlled pathways in cancer cells.»

Myc is a cancer - causing gene responsible for disrupting the normal 24 - hour internal rhythm and metabolic pathways in cancer cells, found a team led by researchers from the Perelman School of Medicine at the University of Pennsylvania.

Furthermore, the hedgehog pathway, a reactivated embryonic pathway in cancer cells, was reported as pyrvinium - sensitive signal transduction mechanism [65].

With today's molecular knowledge of altered metabolic pathways in cancer cells we are making real advances in progressing cancer treatments.

Not exact matches

Cauliflower is high in sulforaphane, a sulphur compound that has been shown to kill cancer stem cells, thereby slowing tumor growth and support liver detoxification pathways.

The findings are published alongside several papers in other Cell journals this week examining molecular pathways using The Cancer Genome Atlas (TCGA).

«Imagine if we could create circuits that detect defects in cancer cells and then turn on pathways that lead to the death of those cells,» he says.

The team found that connective - tissue cells adjacent to colon cancer stem cells secrete growth factors that activate a molecular pathway in other cells that is vital to maintaining stem - cell - like qualities.

In addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researcherIn addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researcherin cancers, according to the researchers.

Schwarz and her colleagues used three different drugs, alone and in combination, to deprive cervical tumors of glucose and block downstream metabolic pathways that help protect cancer cells from building up toxic free radicals.

So we'd need to find a way to shut off this signaling pathway specifically in cancer cells.»

Now, in a new study using laboratory - grown cells and mice, Johns Hopkins scientists report that a method they used to track metabolic pathways heavily favored by cancer cells provides scientific evidence for combining anti-cancer drugs, including one in a nanoparticle format developed at Johns Hopkins, that specifically target those pathways.

The scientists identified several, including the investigational cancer drug BEZ235, which blocked a key metabolic pathway in flu - infected human lung epithelial cells.

The pathway helps to regulate cell division and is often deregulated in cancer cells.

Genes with increased activity are in metabolic pathways that allowed cancer cells to bypass BRAF altogether and continue to grow and divide.

However, the Moffitt scientists suggest that it may be possible to target the TGF - β - miR183 - DAP12 pathway in patients with lung cancer to activate the immune system and kill cancer cells.

The publication, «Androgens Regulate Prostate Cancer Cell Growth via an AMPK - PGC - 1α - Mediated Metabolic Switch,» featured online in Oncogene, illuminates a known metabolic pathway as a potential novel therapeutic target.

They call this form of activation «non-ligand-dependent,» and in a complex series of biochemical and animal experiments, traced the pathway through which FER's binding to MET inside the cell sets off a cascade of cell - signaling events, all directly connected in prior research with cancer initiation, including RAC1 / PAK1 and SHP2 - ERK.

Scientists now know that what matters most in determining the behavior of a particular cancer (and its response to specific therapy) are the molecular pathways that drive malignant cell growth instead of where the tumor begins in the body.

A study led by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified an abnormal metabolic pathway that drives cancer - cell growth in a particular glioblastoma suCancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified an abnormal metabolic pathway that drives cancer - cell growth in a particular glioblastoma suCancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified an abnormal metabolic pathway that drives cancer - cell growth in a particular glioblastoma sucancer - cell growth in a particular glioblastoma subtype.

Half of all melanomas harbor an activating mutation in the BRAF gene that turns on the cancer signaling pathway in cells known as the MAP kinase pathway.

Rare stem - like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researcancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researCancer Center researchers.

In addition to the COX enzyme pathway, Dr. Roberts says other studies have shown that aspirin blocks additional cell - signaling cascades that promote cancer development.

Autophagy has emerged as a key pathway that cancer cells use to survive in the face of assault by chemotherapy and radiation; however, autophagy as a potential druggable mechanism in patients who become resistant to BRAF inhibitors has not been investigated.

These pathways appeared to be dialed down in the cancer cells, allowing for evasion.

«In a large number of diseases, ranging from cancer to ALS, major stress occurs in the affected cells, leading the UPR pathway to be triggered,» he saiIn a large number of diseases, ranging from cancer to ALS, major stress occurs in the affected cells, leading the UPR pathway to be triggered,» he saiin the affected cells, leading the UPR pathway to be triggered,» he said.

«Elevated calcium triggers multiple signaling pathways that promote cell doubling, survival and changes in the cell that promote cancer invasion and metastasis,» says Dr. Copland.

Researchers at Boston University School of Medicine (BUSM), under the direction of Sam Thiagalingam, PhD, found that a protein secreted by BLBC cells, called periostin (POSTN), acted to nurture and support cancer stem cells by activating a distinct signaling pathway in these cells.

Importantly, like cancer cells with other mutations in the HR repair pathway, CHD1 - depleted prostate cancer cells proved to be hypersensitive to chemotherapeutic drugs causing DNA breaks, such as Mitomycin C, Irinotecan and PARP inhibitors.

An enriched hops extract activates a chemical pathway in cells that could help prevent breast cancer, according to new laboratory findings from the UIC / NIH Center for Botanical Dietary Supplements Research at the University of Illinois at Chicago.

Cancer cells often alter their metabolic pathways in order to synthesize the materials they need for rapid growth.

Her research has recently shown that a signaling pathway dubbed «hedgehog» is important not only for normal development of stem cells but also for the growth of cancer cells in chronic myelogenous leukemia.

Researchers have pinpointed the cellular pathway that allows the herbicide atrazine to mimic estrogen and fire up cancer cells, according to a study published January 16 in Environmental Health Perspectives.

His lab studies a particular signaling pathway, the RAS / RAF / MEK / ERK pathway, which regulates cell growth and survival in several cancers.

In particular, it has been shown that cells with other HR repair pathway defects, such as BRCA mutations frequently found in breast and ovarian cancer, are sensitive to inhibition of the enzyme PARP, and the PARP inhibitor Olaparib has been approved for treatment of BRCA - mutated ovarian cancerIn particular, it has been shown that cells with other HR repair pathway defects, such as BRCA mutations frequently found in breast and ovarian cancer, are sensitive to inhibition of the enzyme PARP, and the PARP inhibitor Olaparib has been approved for treatment of BRCA - mutated ovarian cancerin breast and ovarian cancer, are sensitive to inhibition of the enzyme PARP, and the PARP inhibitor Olaparib has been approved for treatment of BRCA - mutated ovarian cancers.

The scientists also studied the role this pathway might play in cancer cells.

The HER2 pathway is mutated in many cancers, which drives tumors, but inhibitors of this pathway, such as lapatinib, have only limited success because cancer cells quickly adapt.

In this webinar we will explore how cancer cells are able to reprogram their metabolic pathways to enable energy production under conditions that are disabling to most normal cells.

Geschwind, a professor in the Russell H. Morgan Department of Radiology and Radiological Science at the Johns Hopkins University School of Medicine and its Kimmel Cancer Center, and others at Johns Hopkins have been studying the experimental drug as a cancer treatment for over a decade because of its ability to block a key metabolic pathway of cancer Cancer Center, and others at Johns Hopkins have been studying the experimental drug as a cancer treatment for over a decade because of its ability to block a key metabolic pathway of cancer cancer treatment for over a decade because of its ability to block a key metabolic pathway of cancer cancer cells.

They work particularly well if the cancer cells they attack already have defects in the corresponding DNA repair pathways, as it frequently occurs in breast cancer and other tumors.

In a study described in the January 13 issue of Cancer Cell, Marikki Laiho, M.D., Ph.D., and her colleagues say their work focused on the ability of a chemical dubbed BMH - 21 to sabotage the transcription pathway RNA Polymerase pathway (POL I), shutting down the ability of mutant cancer genes to communicate with cells and replicatIn a study described in the January 13 issue of Cancer Cell, Marikki Laiho, M.D., Ph.D., and her colleagues say their work focused on the ability of a chemical dubbed BMH - 21 to sabotage the transcription pathway RNA Polymerase pathway (POL I), shutting down the ability of mutant cancer genes to communicate with cells and replicatin the January 13 issue of Cancer Cell, Marikki Laiho, M.D., Ph.D., and her colleagues say their work focused on the ability of a chemical dubbed BMH - 21 to sabotage the transcription pathway RNA Polymerase pathway (POL I), shutting down the ability of mutant cancer genes to communicate with cells and replCancer Cell, Marikki Laiho, M.D., Ph.D., and her colleagues say their work focused on the ability of a chemical dubbed BMH - 21 to sabotage the transcription pathway RNA Polymerase pathway (POL I), shutting down the ability of mutant cancer genes to communicate with cells and replcancer genes to communicate with cells and replicate.

In examining these remaining myeloma cells, the Yale team discovered a previously unidentified biologic pathway induced by the immune modulating drugs that enabled the residual cancer cells to survive and proliferate.

The Nature Communications paper covers lung cancer cells; a similar phenomenon of collective invasion led by distinctive cells has been observed in breast cancer, but different genes and biochemical pathways appear to be important in each system.

The new study, a comprehensive analysis of the genomes of 178 primary cervical cancers, found that over 70 percent of the tumors had genomic alterations in either one or both of two important cell signaling pathways.

A protein in the TOR signalling pathway, called SREBP, controls the flow of messages to the endoplasmic reticulum telling it to expand — and could allow cancer cells to produce enough proteins and lipids to fuel their non-stop growth.

They found that silencing the TOR signalling pathway — activated in many different types of cancer — increased ER stress in the cells.

«I wouldn't be surprised, and this is a bit of speculation, if GATA - 3 may have a function in promoting certain breast cancer and T - cell leukemia through promoting the MYC pathway.»