Sentences with phrase «pathways in these diseases»
«The mitochondrial and lysosomal pathways are two critical pathways in disease development,» said Krainc, who also is the director of the Center for Rare Neurological Diseases and a professor of neurological surgery and of physiology.
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Systems biology is an approach to biomedical research in which scientists combine complex «omics» datasets to develop a more complete understanding of complex biological systems, such as the regulation of whole genome - level transcription, regulation of the 3D genome, the role of signaling and metabolic pathways in disease, and more.
His research focuses on understanding the role of inflammation in retinal degenerative diseases and seeks to target inflammatory pathways in these diseases using gene therapy.
New biological treatments using antibodies or antagonists against receptors or inflammatory enzyme inhibitors (e.g. CXCR2 antagonists, phosphodiesterase - 4 inhibitors, endothelin receptor antagonists and kinase inhibitors) to suppress inflammatory pathways in diseases such as asthma, COPD, idiopathic pulmonary fibrosis, cystic fibrosis and pulmonary hypertension.
Biomarkers are critical for therapeutics development because they can provide indications of the biological pathways in the disease process, the progression of the disease, and the efficacy of potential treatments.
Not exact matches
He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.
Knowing the key players in the entire NOD2 pathway, from initiators to enhancers, would pave the way for new strategies to treat inflammatory diseases, Mr Stafford said.
Dr Nachbur said faults in how the NOD2 pathway was controlled could enable the cell to continue to cause inflammation long after the bacterial threat has passed, leading to chronic inflammatory diseases.
«Is this pathway of the normal developing brain somehow reactivated in the adult brain in the case of neuro - injury or neurodegenerative disease?»
Research in Parkinson's and Huntington's has uncovered additional examples of disease proteins that, when mutated, stymie protein clearance pathways in neurons.
Such compounds might prevent overstimulation of the glutamate pathway, which appears to play a role in Alzheimer's and other brain diseases.
While there were physiological changes in the rats on low - fat diets, including lower body weight, Moody says they were most encouraged to see the changes in specific metabolic pathways related to type 2 diabetes, suggesting changes in rats» risk for the disease.
In a new study published in the Journal of Allergy and Clinical Immunology, Paller, the Northwestern Medicine chair of dermatology, together with Dr. Emma Guttman - Yassky of Mount Sinai Medical School, discovered that an arm of the immune system — the Th17 pathway — in these patients is way too active, and the higher its activity, the worse the disease severitIn a new study published in the Journal of Allergy and Clinical Immunology, Paller, the Northwestern Medicine chair of dermatology, together with Dr. Emma Guttman - Yassky of Mount Sinai Medical School, discovered that an arm of the immune system — the Th17 pathway — in these patients is way too active, and the higher its activity, the worse the disease severitin the Journal of Allergy and Clinical Immunology, Paller, the Northwestern Medicine chair of dermatology, together with Dr. Emma Guttman - Yassky of Mount Sinai Medical School, discovered that an arm of the immune system — the Th17 pathway — in these patients is way too active, and the higher its activity, the worse the disease severitin these patients is way too active, and the higher its activity, the worse the disease severity.
Clinically important findings suggest that targeting the epidermal growth factor receptor (EGFR) and the fibroblast growth factor receptor (FGFR) cellular pathways may benefit thousands of patients with this disease, according to the study published today in the journal PLOS Genetics.
Scientists have shifted from studying single molecules to investigating large complexes of interacting biological macromolecules involved in processes such as metabolic pathways, gene expression, and development of disease.
We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»
Defects in these pathways can provide critical clues for how to best intervene in the disease with drugs.
After exploring the molecular pathway in mice, the researchers focused on cardiac stem cells in patients with heart disease.
The network provides an invaluable resource for identifying targets to treat the disease and has been used to implicate a particular signaling pathway involved in cell motility.
«Cardiac stem cells from heart disease patients may be harmful: Researchers discover molecular pathway involved in toxic interaction between host cells and immune system.»
«That made me wonder if there's a stress - induced pathway that could link inhibition with inflammation and the diseases we're interested in, such as diabetes.
Co-author Fred Reike, who specialises in retinal disease, says that quantum dots have great potential in this area because they directly affect ion channels, which play a key part in the signalling pathways of vision.
David Kessler, the former commissioner of the Food and Drug Administration, is calling for a big government - funded research project to help fill in the gaps in genetic pathways in people, which are turning out to be far more complex than expected for illnesses such as heart disease and which may be beyond the ability of private companies and smaller labs to figure out and pay for.
Longer - term goals are therapies that more directly target the major pathway in this typically age - related disease.
Researchers uncovered the following pathway: gut bacteria stimulate intestinal B lymphocytes to release interleukin (IL)-10 that, in turn, induces development of regulatory T lymphocytes that prevent excessive inflammatory responses and limit immune - mediated disease.
Most people now accept the need to cull millions of farmyard animals in the face of epidemics like mad cow disease, but it is hard to imagine killing beloved puppies, bunnies, and kittens, even if those pets do turn out to offer a pathway for a dangerous new disease.
The fact that TAS - 102 temporarily halted the disease in many of these patients suggests that it operates through a different biochemical pathway than 5 - FU, and therefore may serve as an alternative to standard therapy.
By giving patients an antibody targeting a key molecule in the inflammatory pathway, investigators reduced heart disease and stroke by 15 %, they reported last week.
Since molecules that target CCR3 have already been developed by the pharmaceutical industry for other diseases, the researchers are now hoping to explore this new therapeutic pathway, which could reduce the aggressiveness of prostate cancer in obese patients.
Because this estrogen - driven pathway would be much weaker in males, the work may both explain the heart disease gender gap and suggest that women who use COX - 2 inhibitors may be at higher risk for atherosclerosis than men, says FitzGerald.
Understanding what happens with the UPR in disease is key to illuminating the normal operation of this essential pathway — and to providing insights into the development of targeted therapies.
Three - quarters of chronic obstructive pulmonary disease (COPD) cases have their origins in poor lung function pathways beginning in childhood.
«Our research has identified a gene affecting another type of ischemic stroke, due to small vessel disease, and also suggests some genes may be associated with both ischemic and hemorrhagic stroke and may act through a novel pathway affecting pericytes, a type of cell in the wall of small arteries and capillaries.
«We have identified a pathway in microglia that may be targeted to ultimately slow disease progression in ALS and are exploring potential therapeutic strategies and may have broader implications for diseases such as Alzheimer's and Parkinson's Disease amongst others.disease progression in ALS and are exploring potential therapeutic strategies and may have broader implications for diseases such as Alzheimer's and Parkinson's Disease amongst others.Disease amongst others.»
«This characteristic genetic alteration suggested that inhibiting the PD - 1 pathway might be particularly effective in this disease.»
Many of the genes identified by Dr. Papapanou and his team are implicated in immune and inflammatory pathways, confirming laboratory and clinical observations of the development of periodontal disease.
Rare stem - like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researchers.
An unexpected finding was that many of the innate immunity pathways that were active in the late stages of these inherited blinding diseases were the same as those that are associated with more common vision disorders including diabetic retinopathy and age - related macular degeneration, or AMD.
Understanding the role of the microbes that live in the gut and help process nutrients not only promises a fuller understanding of the link between genes, diet and disease, but may also be a pathway to pinpointing the genes responsible for conditions like diabetes.
That in turn makes it possible to highlight the exact neural pathways involved in the various forms of psychiatric disease.
The researchers» discovery of a control switch that acts on the UPR pathway, published March 25 in the online edition of EMBO Reports, opens new drug development avenues for treating a wide variety of diseases by modulating the UPR pathway to prevent excessive cell death.
«We hope that the results from this study will enable investigators to test the relevance of the maresin pathway in human disease,» said Charles N. Serhan, Ph.D., a researcher involved in the work from the Brigham & Women's Hospital and Harvard Medical School in Boston, Mass. «Moreover, we hope to better understand resolution biology and its potential pharmacology so that we can enhance our ability to control unwanted inflammation and improve the quality of life.»
«The iPS cells may also help us identify treatments for more common diseases, such as atherosclerosis and vascular calcification, because the same bone morphogenetic protein pathways are involved in these medical conditions.»
«We show that the mTORC1 pathway is already impaired in Huntington's disease, and that improving how the pathway functions actually has a protective effect,» said Davidson.
«In a large number of diseases, ranging from cancer to ALS, major stress occurs in the affected cells, leading the UPR pathway to be triggered,» he saiIn a large number of diseases, ranging from cancer to ALS, major stress occurs in the affected cells, leading the UPR pathway to be triggered,» he saiin the affected cells, leading the UPR pathway to be triggered,» he said.
We saw the same processing pathway in a wide variety of diseases, with the same patterns of disruption of the pathway.»
In Parkinson's the pathways are thought to be out of balance, with interrupted motor cells causing the debilitating tremors and loss of movement control symptomatic of the disease.
This animation guides us through the immune pathways involved in the disease, from the first signs of self - reactive immune cells to joint damage and other symptoms.This article was reproduced with permission and was first published on January 25, 2016.
«Overall,» Dr. Schwartz added, «the study underscores the importance of rational drug design, in which drugs are designed to interact with specific molecular pathways involved in a particular disease.
The compound suppresses an inflammatory pathway that is overactive in many autoimmune diseases, suggesting that it may be effective against multiple sclerosis, rheumatoid arthritis, lupus and other autoimmune diseases as well as psoriasis.