Published in PLOS Neglected Tropical Diseases, they propose the use of pre-cut filter paper to store samples for detection of anti-Japanese encephalitis virus antibodies from
patient cerebrospinal fluid.
Not exact matches
For one, it's made it clear that using tools like PET scans and
cerebrospinal fluid testing can help pinpoint which
patients have amyloid present in the brain for the treatments to act on.
Crimson receives daily feeds of information on biosamples — mostly blood, but also urine, tissue,
cerebrospinal fluid, and bacterial collections — from
patients in Harvard - affiliated clinical laboratories and the pathology laboratory, which includes some 5000 blood samples collected daily at Brigham and Women's and Massachusetts General hospitals.
They also typically scrutinize
patients»
cerebrospinal fluid for two main signs: buildup of protein and the absence of inflammatory white blood cells, he says.
Options include further refining experimental tests that diagnose the illness using
cerebrospinal fluid, as well as using mobile PET clinics to reach more
patients.
The test, which measures beta amyloid plaque levels in
cerebrospinal fluid, successfully diagnosed 15 Alzheimer's
patients and wasn't tripped up by 19 people with other neurological diseases.
Authors examined the association between SVD and AD pathology by looking at magnetic resonance imaging (MRI)- based microbleeds (MB), white matter hyperintensities (WMH) and lacunes (which are measures for SVD) along with certain protein levels in
cerebrospinal fluid (CSF) which reflect AD pathophysiology in
patients with AD, VaD and healthy control
patients.
One hallmark of bacterial meningitis is reduced glucose levels in the
cerebrospinal fluid (CSF) of
patients, which allows a physician to quickly begin appropriate antibiotic treatment.
The guidelines provide parameters regarding when clinicians should consider the possibility of ventriculitis (inflammation of the ventricles in the brain) or meningitis (inflammation of the lining of the brain or spinal cord) in
patients who have
cerebrospinal fluid shunts and drains (devices placed in the brain to relieve pressure due to fluid buildup), intrathecal drug pumps (for administration of pain medicine or other drugs into the spinal canal), deep brain stimulation hardware (medical devices that provide electrostimulation in the brain to treat Parkinson's disease or other neurological symptoms) or who have undergone neurosurgery or suffered from head trauma.
Migraine sufferers have significantly higher sodium concentrations in their
cerebrospinal fluid than people without the condition, according to the first study to use a technique called sodium MRI to look at migraine
patients.
To test whether Japanese encephalitis virus could be successfully identified from the samples, the researchers carried out a retrospective analysis on
cerebrospinal fluid for
patients tested for the virus between 2009 — 2015 in Laos, with a total of 132 samples containing sufficient fluid volume for testing.
The international team of scientists from University College London, IRBM Promidis, University of British Columbia, and CHDI Foundation developed a new ultra-sensitive test using the Singulex SMC Technology Erenna Immunoassay system that is able to detect mutant huntingtin in the
cerebrospinal fluid (CSF) of HD
patients, including some who carry the HD mutation but have not yet developed symptoms.
The research team also detected elevated interferon - levels in the
cerebrospinal fluid of
patients infected with viral meningitis.
The test requires removing
cerebrospinal fluid (CSF) from
patients by means of a spinal tap, putting samples into a bath of normally shaped prion proteins, and agitating the solution to encourage any abnormal prion «seeds» in the tissue to latch onto the regular proteins.
Data from 304 PD
patients followed for up to 8 years indicate that
patients with higher
cerebrospinal fluid (CSF) α - synuclein levels experienced faster cognitive decline in the following months, although no associations were found between α - synuclein levels and motor changes.
Further studies, including analysis of frozen blood and
cerebrospinal fluid taken from
patients, are underway to test possible drug mechanisms.
One promising avenue of research involves searching for biomarkers such as tau proteins in the
cerebrospinal fluid of
patients.
Immunologist Steven Schutzer of the University of Medicine and Dentistry of New Jersey examined samples of
cerebrospinal fluid, the clear liquid that surrounds the brain and spinal cord, from
patients with each syndrome.
Conducting a cross-sectional study of a large cohort of
patients with different levels of cognitive impairment and different disease stages, the researchers found that the amounts of a TREM2 fragment in the
cerebrospinal fluid were highest during early stages characterized by mild cognitive impairment symptoms.
Brain imaging studies and
cerebrospinal fluid analysis for both
patients were consistent with Alzheimer's disease.
«To date,
cerebrospinal fluid analyses have not been a routine component of assessment and care for
patients with cognitive impairments and suspected Alzheimer's disease in the United States,» Dr. A. Zara Herskovits, of Brigham and Women's Hospital, and Dr. John H. Growdon, of Massachusetts General Hospital, wrote in an editorial that accompanied the study.
These instruments have formed the foundation for the biochemistry cores of two NIH Centers of Excellence (the NIAAA - funded TSRI Alcohol Research Center and the National Institute on Drug Abuse [NIDA]- funded Scripps Center for Cannabis Addiction Neurobiology) and have directly supported other ongoing projects at TSRI (the Methamphetamine NeuroAIDS Research Program, NIDA - funded projects on immunopharmacotherapy [Taffe and Janda laboratories], a project with Dr. Steve Poceta to measure human lumbar
cerebrospinal fluid in Parkinson's
patients with Restless Leg Syndrome, and a U.S. Army grant), as well as assisting non-TSRI collaborators from The Sanford - Burnham Institute, The Salk Institute, and elsewhere.
Su studied plasma and
cerebrospinal fluid samples previously collected from
patients undergoing diagnostic evaluation, who were later identified as having ALS.
To investigate changes in the
cerebrospinal fluid (CSF) immunological profile after treatment switch from first - line injectables to rituximab in
patients with relapsing - remitting MS (RRMS), and to compare the profile in MS
patients with healthy controls (HC).
We examined the APOE4 - by - sex interaction in conversion risk (from healthy aging to mild cognitive impairment (MCI) / AD or from MCI to AD) and
cerebrospinal fluid (CSF) biomarker levels.Cox proportional hazards analysis was used to compute hazard ratios (HRs) for an APOE - by - sex interaction on conversion in controls (n = 5,496) and MCI
patients (n = 2,588).
Evidence of both systemic inflammation and neuroinflammation in fibromyalgia
patients, as assessed by a multiplex protein panel applied to the
cerebrospinal fluid and to plasma.
Methods: We isolated and propagated T whipplei strain TW08 / 27 from the
cerebrospinal fluid of a
patient diagnosed with Whipple's disease.
Pooled
cerebrospinal fluid (CSF) samples from nPTLS
patients, CFS
patients, and healthy volunteers were comprehensively analyzed using high - resolution mass spectrometry (MS), coupled with immunoaffinity depletion methods to reduce protein - masking by abundant proteins.
We have previously described such variation seen between isolates infecting the blood and
cerebrospinal fluid (CSF) of a single
patient during a case of bacterial meningitis.
Increased glycated ApoE particles have been detected in the
cerebrospinal fluid (CSF) of AD
patients.34, 35 The physiological insult of glycated ApoE is that ApoE helps transport LDL particles (and their critical cholesterol and fatty acid passengers) across the blood brain barrier.
While it may not be practical for many
patients, examination of
cerebrospinal fluid (CSF) is best to specifically define the nature of inflammation in the PD
patient:
Patients with hydrocephalus have abnormal accumulation of
cerebrospinal fluid (CSF) in the ventricles, or cavities, of the brain.
Cerebrospinal fluid (CSF) obtained from cats with FIP in the CNS may be normal in
patients with focal or subependymal lesions.
The type of GME is confirmed by the
patient's set of symptoms, CSF (
cerebrospinal fluid) analysis, and the distribution of lesions revealed by magnetic resonance imaging (MRI) or computed tomography (CT).
Higher
cerebrospinal fluid homovanillic acid levels in depressed
patients with comorbid posttraumatic stress disorder
Platelet MAO activity and monoamine metabolites in
cerebrospinal fluid in depressed and suicidal
patients and in healthy controls