Sentences with phrase «patient cohort from»
However, these approaches have not yet delivered all that they promised, partly due to the inherent genetic variability between patient samples, but also because the diagnostic / prognostic accuracy of the cancer signatures identified tends to be linked to the patient cohorts from which those signatures were obtained.
http://www.ifom-ieo-campus.it/ Not exact matches
From this cohort, 1,650 patients (330 patients per local therapy) were randomly selected.
To further analyze whether FGFR fusions are present across different types of cancers, the researchers extended their assessment and analyzed data generated from an internal cohort of 322 patients, as well as from a large cohort of 2,053 patients recruited to The Cancer Genome Atlas.
They are based on a retrospective cohort study of 7,431,858 patients in the University HealthSystem Consortium database, which contains information from contributing academic medical centers in the United States and affiliated hospitals.
In this new work, BIDMC researchers and co-lead authors Sarinnapha M. Vasunilashorn, PhD, and Long Ngo, PhD, examined data from a patient cohort called SAGES (Successful Aging after Elective Surgery Study).
The study included 677 patients from the multicentre, prospective cohort study B - SAFE.4 BMIPP scintigraphy, ECG and C - reactive protein assessment was performed in all patients.
The UC research team looked at 3,679 individuals with Type 2 diabetes from a de-identified cohort of patients at the Cincinnati Veterans Affairs Medical Center and who were followed for a 10 - year period, explains Charuhas Thakar, MD, professor and director of the UC Division of Nephrology, Kidney CARE Program.
Researchers conducted a retrospective cohort study of patients admitted to the ICU at Barnes - Jewish Hospital in St. Louis, Missouri from 2005 through 2012.
The Chronic Hepatitis Cohort Study is an analysis of records from a large, geographically and racially diverse group of 9,783 patients receiving care at four large U.S. health systems: Henry Ford Health System in Detroit; Kaiser Permanente Northwest in Portland, Oregon; Kaiser Permanente in Honolulu and Geisinger Health System in Danville, Pennsylvania.
In this study, researchers analyzed prostate tissue biopsies from two cohorts of prostate cancer patients.
After a 15 - month follow up, 16 patients from two cohorts had partial responses, with an overall response rate of 38 and 27 percent in each of the two cohorts.
The researchers analyzed microarray data of samples from German patients and from an IPF cohort of the Lung Tissue Research Consortium in the U.S.
Dr. Mitra undertook a large - scale bioinformatics approach to evaluate over 700 ovarian cancer molecular profiles from four patient cohorts.
As follow up, Bedrosian and her team hope to mine the randomized controlled trial findings from the 1980s, matching those cohorts to current NCDB patients to see if a similar survival benefit could be observed.
«Accordingly, we examined the effects of allergic disease on respiratory health in two sets of patients with COPD, one a nationally representative sample of 1,381 COPD patients from the National Health and Nutrition Survey III (NHANES III) and the other a cohort of 77 former smokers with COPD from a study of the effects of endotoxin exposure on health status.»
In the cohort of patients who received transplants from mismatched unrelated donors, all 43 patients received four doses of abatacept with a calcineurin inhibitor and methotrexate.
The second cohort of 140 patients with human leukocyte antigen - matched unrelated donor transplants completed enrollment in November 2017, with data expected from this randomized double - blind arm of the study in the next six months.
After finding that one of Laron's patients — a Moroccan Jew — had an identical mutation to that of the Ecuadorian cohort, Rosenbloom, Guevara - Aguirre, and Laron proposed that the genetic defect for the growth hormone receptor came to Ecuador from the Iberian Peninsula five centuries before.
Dr. Zhang points out that the unique value of this study derives from the ability to perform longitudinal assessments of cognition in PD patients over a long time period and access to data from a large cohort that began when patients were in the earliest stage of disease.
Dr Matt Hurles, who led the study from the Sanger Institute, said: «This study has the largest cohort of such families in the world, and harnesses the power of the NHS, with 200 clinical geneticists and 4,000 patients.
Unlike other solid tumors, there has been limited progress in understanding the contribution of genetic risk factors to the development of uveal melanoma, researchers say, primarily due to the absence of comprehensive genetic data from patients as the large sample cohorts for this rare cancer type have not been available for research.
Researchers were able to access CSF samples from the deprenyl and tocopherol antioxidative therapy of Parkinsonism (DATATOP) study, which is the largest cohort assembled to date with longitudinal collection of biological fluids and clinical data from PD patients.
This led to the collection of bone marrow samples from larger cohorts of patients with the Ottawa Hospital Research Institute, as well as those from Western University and Hamilton Health Sciences, for the next steps of investigation.
The study results of 50 patients from this cohort are now described in the New England Journal of Medicine.
The team further analysed tissue samples from a cohort of approximately 1,000 patients to establish the correlation of high levels of CD151 to poor prognosis.
The researchers identified a cohort of 7,704 RA patients from the Swedish Biologics Register with no previous incidence of ischemic heart disease who started their first TNF inhibitor between 2001 and 2010.
The initiative will also launch a new cohort study of 200 patients and 200 controls recruited from centers around the country.
A comparator cohort of 23,112 matched, patients with RA who had never taken a biologic were identified from the National Patient Register.
«Furthermore, analysis of tumor samples from large cohorts of colorectal cancer patients revealed that activation of the loop is associated with metastasis,» Hermeking reports.
In a small prospective study of 365 patients, researchers made a surprising finding: While younger patients had better function and range of motion before surgery, it was the older cohort that saw greater improvement from pre-operative levels after surgery.
In the third cohort — 11 new patients from Dana - Farber — the researchers also evaluated cell - free DNA (cfDNA).
Researchers at Henry Ford in Detroit analyzed data and shoulder function scores from two patient cohorts with osteoarthritis who had surgery: 262 patients under 65 and 103 patients older than 75.
Evaluation of 66 patients with JDM, recruited from the UK JDM Cohort and Biomarker Study and actively treated with anti-TNF agents, showed significant improvements in muscle and skin involvement, as well as in overall disease activity.
They analyzed a large cohort of human patient samples from the human kidney biobank managed by Susztak and found that the interconversion might also occur in patients with kidney disease and likely contributes to a condition when the kidneys can not remove enough acid from the body.
To identify patients who could possibly benefit most from BCT, both time cohorts were divided into subgroups.
«Now that spinal stimulation has been successful in four out of four patients, there is evidence to suggest a large cohort of individuals, previously with little realistic hope of any meaningful recovery from spinal cord injury, may benefit from this intervention.»
Published in PLOS ONE, Sun's paper used data from the Haimen City cohort, which was established in eastern China, of hepatitis B patients.
The number of patient receiving no treatment also increased from 7 to 40 percent for the youngest and oldest elderly patient cohorts in the study.
Instead of a traditional randomised cohort selected using strict criteria, the new study used specific, representative patients drawn directly from GP practices in which they were receiving care for COPD.
The NYGC and its founding member institutions are conducting additional studies involving Watson to help accelerate the discovery of potentially actionable sequence variants in various types of cancer, including an ongoing study that involves DNA and RNA from a larger cohort of glioblastoma patients, and a study of 200 patients with different types of cancer.
«Our research finds that a set of genetic risks identified from UK patients with a clinical diagnosis of childhood ADHD also predicted higher levels of developmental difficulties in children from a UK population cohort, the ALSPAC,» said Thapar.
Methods: Consecutive first - ever stroke or TIA patients (n = 266) from the Tel Aviv Acute Brain Stroke Cohort (TABASCO) study were enrolled.
In our JTM paper, work that was primarily supported by the Chronic Fatigue Initiative, we sequenced the mitochondrial DNA from a cohort of ME / CFS patients and healthy individuals, using DNA extracted from white blood cells stored in the biobank developed by the Chronic Fatigue Initiative.
Conclusions and Relevance The study results, derived from a large cohort of patients with long follow - up time, suggest that the rate of revision septorhinoplasty is low, but certain patient characteristics are associated with higher revision rates.
The investigated cohort consisted of 1802 patients with oral prednisolone and alendronate treatment and 1802 matched controls, selected from 6076 patients with oral prednisolone but without alendronate treatment (Figure 1 and Figure 2).
Retrospective cohort analysis of 175842 patients undergoing septorhinoplasty between January 1, 2005, and December 31, 2009, from the Healthcare Cost and Utilization Project's State Inpatient Databases, State Ambulatory Surgery and Services Databases, and State Emergency Department Databases from California, Florida, and New York.
EATRIS offers the entire spectrum of high - end research infrastructure and patient cohorts all accessible though just one portal, and maximises product potential by providing support from discovery to clinical trials.
By obtaining the entire mitochondrial genome sequences from cells of ME / CFS patients and an age - matched cohort, it is possible to determine whether cases have accumulated more somatic mutations in mitochondrial DNA than expected.
The study results, derived from a large cohort of patients with long follow - up time, suggest that the rate of revision septorhinoplasty is low, but certain patient characteristics are associated with higher revision rates.
Final results of a cohort from a phase II monotherapy trial of quizartinib in acute myeloid leukemia patients showed that more than half of patients 60 years of age and older who harbored an internal tandem duplication in the FMS - like tyrosine kinase 3 had a composite complete remission.