Sentences with phrase «patient tumor samples»

Establishing a repository of laboratory models derived from patient tumor samples that will enable researchers to more thoroughly investigate drug resistance

«The enhancing effect was not seen in a patient tumor sample with a low level of NRP - 1 expression on the vasculature.

Not exact matches

For example, TCGA, with genomic data on 33 tumor types taken from samples from 11,000 patients, is finishing 2018 by publishing a series of papers and holding a symposium.

Users simply collect a blood sample from a patient, feed it into the device, and retrieve any purified tumor cells a few hours later.

This study analyzed preserved tumor samples from 43 prostate cancer patients who later received radiation therapy after rising PSA levels were detected following a radical prostatectomy.

Analyzing a database of nearly 800 multiple myeloma patient samples, they discovered that 162 patients with low ADAR1 levels in their tumor cells survived significantly longer over a three - year period compared to 159 patients with high ADAR1 levels.

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

HBI member V. Wee Yong, PhD and research associate Susobhan Sarkar, PhD, and their team including researchers from the Department of Clinical Neurosciences and the university's Southern Alberta Cancer Research Institute, looked at human brain tumor samples and discovered that specialized immune cells in brain tumor patients are compromised.

In blood samples from 1005 patients with eight types of tumors that had evidently not yet metastasized, the test detected between 33 % and 98 % of cases, depending on the tumor type (see graph, above).

The team looked at tumor samples taken from 314 patients diagnosed with DCIS.

31: The percentage of genetic mutations shared by all the tumor samples taken from a patient with kidney cancer.

Plasma samples of patients with NSCLC is a less invasive method and has been used as surrogate tumor tissues for detecting genetic alterations.

«This gives us novel and exciting new therapeutic options to pursue based on results from drug screenings of primary tumor samples from patients.»

To that end, in collaboration with the University of Zurich and MD Anderson Cancer Center, the researchers tested melanoma tumor samples from human patients undergoing treatment with the same targeted therapies.

The investigators looked at 4,278 tumor samples from a tissue repository of patients with GI tract cancers.

Spearheaded by first author Christopher McNair, PhD, a graduate student in the laboratory of Dr. Knudsen, the study undertook an extensive analysis of tumor samples and cell - free DNA samples from patients with advanced, lethal - stage prostate cancer.

Using tumor samples from a patient, they do lab tests to determine which substances can first make the different types of cancer cells uniform and then effectively kill them.

The ambitious plan was to create a new shared resource of tumor samples with attached patient information.

A global analysis of metabolites and small molecules in urine samples from patients with adrenal cancer has identified four biochemicals that, when measured together, can distinguish malignant from benign adrenal tumors, according to study results presented at the 2015 Annual Clinical Congress of the American College of Surgeons.

Analysis of blood and tissue samples from one patient revealed that plakoglobin was expressed in CTC clusters but not single CTCs and also was expressed in some portions of both the primary tumor and metastases.

The researchers analyzed the samples using immunohistochemistry and RNA sequencing to study the changes in the tumor immune microenvironment of patients who received and did not receive chemotherapy, and changes before and after chemotherapy.

From tissue and cell samples from five glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew into very different tumors in the lab.

To see whether Lin28 might be a factor in Wilms tumor development, Daley and an international team of collaborators measured the gene's expression in tumor samples from 105 Wilms patients.

The approach was most successful in making a difference in samples from the two patients in which the smaller - sized tumor DNA was not readily apparent, which may represent patients with low tumor burden and previously difficult to detect circulating tumor DNA.

Nana - Sinkam and his colleagues examined lung - tumor samples from 81 patients with stage - 1 nonsmall - cell lung cancer and tumor - cell lines.

To better understand the formation of metastases in pancreatic cancer, Christine Iacobuzio - Donahue, M.D., Ph.D., professor of pathology at Memorial Sloan Kettering Cancer Center, collected tumor samples from eight patients with the most common form of pancreatic cancer (pancreatic ductal adenocarcinoma) immediately after their deaths.

The researchers next will turn to analyzing the presence of myoferlin in samples from numerous human tumor types available in an Ohio State tissue bank, which will allow them to compare protein levels in tumors to clinical outcomes for the patients who provided the samples.

«Shifting protein networks in breast cancer may alter gene function: Changes in gene function in tumor samples correlate with patient survival.»

«We used biopsied tumor samples from DIPG patients to create models in the lab, which we studied and then used to test a novel, targeted approach to treating the tumor.

The team chose to compare breast tissue from healthy individuals with tumor samples taken from breast cancer patients — including both primary tumors that had not spread from the breast to other body sites, and highly aggressive, metastatic tumors.

The scientists also studied patients» tumor samples and performed visual oral examinations of spouses / partners.

Unlike other solid tumors, there has been limited progress in understanding the contribution of genetic risk factors to the development of uveal melanoma, researchers say, primarily due to the absence of comprehensive genetic data from patients as the large sample cohorts for this rare cancer type have not been available for research.

«Being able to safely take tissue samples will also allow us to test for specific tumor sub-types and better decide the most appropriate treatment for each individual patient,» added Dr Booton.

«In the tumor sample from a patient with high NRP - 1 expression, there was a significant improvement in the efficacy of the nanoparticle to induce tumor shrinkage,» said Nel.

For example, cancer cells floated above denser blood cells, which could allow clinicians to spot rare circulating tumor cells in a patient sample.

To make the vaccine, researchers took a sample of a patient's tumors, which in this trial were made up of B cells (white blood cells that help the body battle disease and infection).

The mesothelioma caused by long carbon nanotubes mice was in many ways similar to tumor samples from patients.

Analyzing the poly - G profiles of primary and metastatic colon cancer samples from 22 patients revealed that how the primary and metastatic tumors related to each other was different for each patient.

However, an analysis of the samples showed a wide variation of EGFRvIII expression in patients and over time and in different areas of their tumors.

Answering important clinical questions — such as whether genetic diversity is a risk factor for aggressive tumor development or how it relates to treatment resistance — requires analyzing samples from many patients with different types of cancer.

«Furthermore, analysis of tumor samples from large cohorts of colorectal cancer patients revealed that activation of the loop is associated with metastasis,» Hermeking reports.

To confirm that the missing mutations were important for generating an immune response, the researchers cultured a subset of the neoantigen protein fragments containing the tumor mutations with immune cells taken from three patients» blood samples.

Analysis of liver tumor samples from patients showed that NRF2 expression correlated with tumor metastasis.

Working in mouse models of breast cancer and breast tumor samples from patients, Longmore and his colleagues showed that a protein that sits on the surface of tumor cells, called DDR2, binds to collagen and activates a multistep pathway that encourages tumor cells to spread.

To search for other characteristics of ccRCC tumors that influences immunotherapy response or resistance, the researchers used whole - exome DNA sequencing to analyze tumor samples from 35 patients treated in a clinical trial with the checkpoint blocker nivolumab (Opdivo).

For 124 evaluable patients for concordance analysis, researchers compared genetic changes in the tumors to those in circulating tumor DNA from the blood samples.

Thirty - seven patients were excluded due to unavailability of the results of the genetic analysis of the tumor or cell - free DNA samples.

The researchers used an enhanced version of a technique they developed called CAPP - Seq to isolate and sequence circulating tumor DNA, or ctDNA, from blood samples from the patients.

Researchers have found a group of circulating tumor cells in prostate cancer patient blood samples which are linked to the spread of the disease, according to new research presented at the National Cancer Research Institute (NCRI) Cancer Conference in Liverpool.

For this study the authors studied tumor samples from 111 patients treated at the Instituto Nacional de Enfermedades Neoplásicas (INEN), in Lima, Perú.