Sentences with phrase «patients after transplant»

Not exact matches

Ten patients not previously infected with hepatitis C took doses of powerful antiviral medications before and after receiving the transplants.

In the early 2000s, Johns Hopkins scientists Leo Luznik and Ephraim Fuchs found that giving patients high doses of cyclophosphamide — a drug derived from nitrogen mustard and used to treat blood cancers — three days after bone marrow transplant successfully thwarts acute and chronic GVHD.

Patients receiving standard immunosuppressive drugs after transplant, as opposed to high - dose cyclophosphamide, have slower recovery of regulatory T - cells in their blood, adds Kanakry.

Of 105,174 patients who received kidney transplants between 2004 and 2012, 488 (0.4 percent) had a record of melanoma after transplant, the authors report.

Targeting exhausted immune cells may change the prognosis for patients with acute myeloid leukemia (AML) relapse after a stem cell transplant, according to Penn State College of Medicine researchers.

Researchers at Dana - Farber / Boston Children's Cancer and Blood Disorders Center report promising outcomes from a clinical trial with patients with a rare form of bone marrow failure who received a hematopoietic stem cell transplant (HSCT) after pre-treatment with immunosuppressive drugs only.

After the transplant, patients receive two days of cyclophosphamide to prevent GVHD and rejection of the new bone marrow.

After their transplants, 51 percent of the patients experienced grades II to IV acute GVHD, the milder form, and 15 percent of the patients experienced the severe forms of acute GVHD (grades III to IV).

Patients receive cyclophosphamide for two days after their bone marrow transplant, in addition to two other chemotherapy drugs given before the transplant.

While some previous studies found that maintenance lenalidomide after autologous hematopoietic stem cell transplant improved overall survival for newly diagnosed multiple myeloma patients, others showed no benefit to this approach.

Marc Hartert and colleagues have studied how patients do after a lung transplant, and their review appears in the current edition of the Deutsches Ärzteblatt International.

«In this large observational study of patients with MS treated with AHSCT, almost half of them remained free from neurological progression for five years after transplant.

Steatosis — when the liver becomes infiltrated with fat — occurs frequently after liver transplantation, but little is known about its actual prevalence in transplant recipients, which risk factors are involved, or what effects the condition has on patients» survival.

After the patient received a transplant of her live - in boyfriend's stool, she was cured.

As we are now able to focus our efforts on improving the overall patient experience and reducing the risk of relapse, the leading cause of death after transplant, we have greatly improved long - term survival outcomes for patients who before might not have had another treatment option.»

Patients recently diagnosed with type 1diabetes who received transplants of their own immune stem cells were able to go without insulin injections for nearly five years after the procedure, scientists report today.

Experience with lymphoma patients, who receive a transplant of their own blood or bone cells after radiation to wipe out their cancer, has shown «there's no doubt it helps,» says bone marrow transplant expert Nelson Chao of Duke University in Durham, North Carolina.

Monitoring immune cell activity — including phenotyping immune cell subsets, tracking cell proliferation, and measuring cytokine production — can provide insights into the overall status of immune function in patients, particularly those undergoing immunosuppression after transplants, enduring cancer treatment, or suffering from autoimmune disease or other pathologies that affect the immune system.

«As a transplant physician, it's beyond heartbreaking to witness a patient develop severe acute graft - versus - host disease after having their leukemia cured through bone marrow transplant,» said Kean.

A decade ago, the medical world was shocked when a patient in Berlin, Germany, had been declared free of HIV after receiving a stem cell transplant to treat cancer.

By receiving transplants of bone marrow cells along with the new kidney, four of five transplant patients with end - stage renal disease were able to stop taking immunosuppressive drugs within about one year after surgery.

Results from a clinical trial investigating a new T cell receptor (TCR) therapy that uses a person's own immune system to recognize and destroy cancer cells demonstrated a clinical response in 80 percent of multiple myeloma patients with advanced disease after undergoing autologous stem cell transplants (ASCT).

If this works out, the patients will have the radiation level measured in their teeth before they receive a bone marrow transplant and again after a certain number of treatments to see if they are in line with the radiation dosage technicians think they are giving the patients, she says.

Only two per cent of patients with life - threatening bleeding after serious injury receive optimal blood transfusion therapy in England and Wales, according to research led by Queen Mary University of London (QMUL) and NHS Blood and Transplant.

Neural fetal cells from a Parkinson's patient retained healthy dopamine production capabilities 24 years after transplant.

«Long - term remissions in some patients after stem cell transplants from donors have been observed, but treatment - related toxicity limits the widespread use of this therapy.»

Young and colleagues used DNA sequencing to study the composition and structure of fecal microbiota (bacteria) in stool samples from 14 patients before and two to four weeks after fecal transplant.

Existing research suggests that less time spent on dialysis before transplant can improve patient outcomes and survival after transplant.

HSCs can be harvested from a suitable donor and then transplanted into a patient, where, after establishing themselves in the bone marrow, they can generate healthy blood cells.

Years after a double hand transplant, this patient can perform complex tasks, including repairing an electrical wire.

Without a lung transplant, pulmonary fibrosis patients typically die within three years after diagnosis.

«The patients who participated in these trials had relapsed as many as four times, including 60 percent whose cancers came back even after stem cell transplants.

After generating T cells against cytomegalovirus, medical biotechnologist Erica Dander, 26, wrote in collaboration with her multi-disciplinary team a successful clinical trial protocol to test whether injecting the T cells could kill infected cells in transplant patients.

Researchers have discovered that a new anti-rejection drug that is gentler on the kidneys after liver transplant also reduces weight gain, which is common after surgery and can lead to serious complications for transplant patients.

After transplant, patients must take anti-rejection drugs so their immune systems don't attack and destroy the transplanted organ.

To find out, they randomized a total of 719 patients between 25 and 35 days after liver transplant into three study arms.

The researchers studied 24 tumor samples from breast cancer patients after the samples were transplanted into mice.

Scientists at Technische Universität München (TUM), together with colleagues from Frankfurt, Würzburg and Göttingen, have now developed a method which could offer patients conservative protection against such infections after a transplant.

Researchers found that transplant patients taking Everolimus gained less weight — and kept it off at one and two years after starting the drug.

Scientists in Germany have developed a new approach that may prevent leukemia and lymphoma patients from developing graft - versus - host disease (GvHD) after therapeutic bone marrow transplants.

After infection, some healthy people experience a month or more of flu - like symptoms, but the disease can cause seizures and potentially fatal encephalitis in the immunocompromised, including patients receiving transplants, those with HIV / AIDS, cancer patients, the elderly, and young children.

Twenty - four of the patients were transplanted successfully after receiving the investigational therapy.

«This condition is one of the main reasons that many bone marrow transplant patients endure long hospital stays after their diseases are cured,» said Kean, who wears a bracelet around her badge from a pediatric patient cured of leukemia one year ago, but is still in the hospital due to complications from GVHD.

Patients received standard medication used after a transplant to prevent GVHD.

About 10 days after the transplant, Strober injects the patient with millions of white blood cells extracted from the kidney donor.

Beilhack and colleagues found that a slightly modified version of STAR2 has a similar effect on human T reg cells, suggesting that the approach could also prevent GvHD in leukemia and lymphoma patients after bone marrow or hematopoietic stem cell transplants.

Between 2004 and 2014, 477 patients treated with BMT at City of Hope underwent standardized neuropsychological testing before their transplant, and at the six - month and one -, two - and three - year marks after transplant; testing was conducted on eight cognitive domains, including executive function, verbal fluency and speed, processing speed, working memory, visual and auditory memory, and fine motor dexterity.

Approximately 40 % of transplant patients experience at least one episode of acute rejection in the first year after they receive an organ.

The therapy is approved by the U.S. Food and Drug Administration for relapsed or treatment - resistant Hodgkin lymphoma, and it is commonly prescribed to patients whose disease has progressed after autologous stem cell transplant, a procedure that replenishes the bone marrow with the patient's own healthy stem cells after therapy.

Of these 34 patients, 13 (38 %) have remained in remission for five years, and an additional two patients whose disease did not progress after BV went on to achieve remission after receiving allogeneic stem cell transplant (in which healthy stem cells are taken from a donor and administered to the patient).