The researchers confirmed that active surveillance appears safe in
patients at low risk and in select patients at intermediate risk, particularly those with GS 6 and PSA greater than 10 ng / ml.
«Blood metal ion levels can identify hip replacement
patients at low risk of ARMD: Blood metal ion levels can effectively identify
patients at low risk of adverse reactions after metal on metal hip replacement.»
The observational study was conducted in more than 25,000 non-valvular atrial fibrillation
patients at low risk of stroke.
Researchers at Christchurch Hospital in Christchurch, New Zealand reviewed published data to test the utility of a single high - sensitivity cardiac troponin T measurement combined with an ECG to safely identify
patients at low risk for MI on presentation to the ED.
Whilst a preference for a (shortened) period of triple therapy remains in the guidance, we recommend that dual therapy with oral anticoagulation and clopidogrel may be considered as an alternative to triple therapy in selected AF
patients at low risk of stent thrombosis or recurrent cardiac events.»
The findings could mean that
patients at lower risk of injury to begin with may not benefit much from a cooldown.
Not exact matches
These
risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the
risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror
patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of
lowering prices or reducing the number of insured
patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or
at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the
risk that physicians and
patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other
risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
, Arsenal is not a charity, Arsenal is a football club trying to to win EPL, not a charity trying to help a player who is overated and useless, he got pay to play a football, not to operate
patients and he got 75m a week to be able to pass the ball correctly, never mind score or assist, I get 480 # / week if my confidence is
low my boss will give me a kick
at back side to sort my self out or the door, we do not have to
risk our chance of winning the game for a sake of Ox, bench him, the best player plays, we don't gonna miss is scoring ability or his assist, we will be less frustrated if he is on the bench typical English player!
The study looked
at intended place of birth to rule out improperly assigning transferred
patients to the hospital group, and included only the
lowest possible
risk women.
If you honestly think a post dates
low AFI
patient is better off
at home with a CPM, you are stunningly ignorant of the
risk that situatin entails.
When deciding on the number of embryos to recommend for transfer, we carefully weigh all factors with the goal of offering each
patient the highest chance of pregnancy with the
lowest possible
risk of a high - order multiple gestation (we have this discussion again
at the time of embryo transfer).
Then they would have the time to really spend with their
patients, address concerns, and take their time with «natural - ish cesareans» Reducing the overall number of women in the hospital giving birth (by having a system that supports
low risk, healthy moms birthing their babies
at home with trained professionals like CPM's and CNM's) would allow moms who birthed through surgery to stay in the hospital longer and receive the one - on - one medical care that they so very much deserve.
All my
patients were
low risk women planning spontaneous vaginal births, and the hospital I trained
at did not offer epidurals (they brought them in only
at the very end of my training years).
Inclisiran
lowers low - density lipoprotein (LDL; «bad») cholesterol for up to one year in
patients with high cardiovascular
risk and elevated LDL cholesterol, according to late - breaking results from the ORION 1 trial presented today in a Hot Line LBCT Session
at ESC Congress.
Nevertheless, neurologist Peter Rothwell, a researcher
at Oxford University and specialist on stroke, has found that 80 percent of such procedures were performed on
low -
risk patients without symptoms — an inappropriate group.
Studies have shown that when doxorubicin is administered slowly, rather than all
at once,
patients may have a
lower risk of heart failure.
«Our research has led to the development of a test that can detect
patients that will benefit from treatment up front and spare those who are
at lower risk from the side - effects of chemotherapy.
An analysis of data on 945
patients with prostate cancer that is managed with active surveillance shows differences in outcomes depending on whether the
patient was
low or intermediate
risk at diagnosis.
Among
patients with hypertension
at high
risk of cardiovascular disease, a program that consisted of
patients measuring their blood pressure and adjusting their antihypertensive medication accordingly resulted in
lower systolic blood pressure
at 12 months compared to
patients who received usual care, according to a study in the August 27 issue of JAMA.
The study also found that racial minority
patients with a strong desire for testing were less likely than white
patients to discuss it with a professional, even though studies show that minority
patients are not
at lower risk for these mutations.
Patients with
low testosterone levels who have then gone on to have testosterone replacement therapy (TRT) could be
at lower risk of cardiovascular events such as heart attack or stroke, according to research published in the European Heart Journal.
In a different study Waghmare presented
at the recent annual meeting of the American Society for Blood and Marrow Transplantation in Orlando, Florida, the researchers teased out a few
risk factors that can drive the development of
lower respiratory tract infections — namely, high levels of steroid use (commonly given to transplant
patients for other complications such as graft - vs.
Patients seen in the emergency department (ED) for chest pain who did not have a heart attack appeared to be
at low risk of experiencing a heart attack during short - and longer - term follow - up and that
risk was not affected by the initial diagnostic testing strategy, according to a study published online by JAMA Internal Medicine.
«We have identified a subgroup of older
patients at sufficiently
low risk of recurrence for whom omission of postoperative radiotherapy after breast - conserving surgery and adjuvant endocrine therapy is a reasonable option.
«Helping physicians discriminate between lesions
at high - and
low -
risk for cancerous transformation could mean fewer unnecessary procedures for
low -
risk patients and earlier interventions for those
at high
risk.»
A test based on the genetic make - up of the Barrett's lesions could benefit
patients through improved diagnosis, giving people
at high
risk of cancer the best care, and reducing the burden of endoscopy for those
at low risk.
Before recalibration, the researchers found that the Surgical
Risk Calculator had a slight tendency to overestimate surgical risk for the lowest and highest risk patients and to underestimate risk for patients at moderate risk of postoperative complicati
Risk Calculator had a slight tendency to overestimate surgical
risk for the lowest and highest risk patients and to underestimate risk for patients at moderate risk of postoperative complicati
risk for the
lowest and highest
risk patients and to underestimate risk for patients at moderate risk of postoperative complicati
risk patients and to underestimate
risk for patients at moderate risk of postoperative complicati
risk for
patients at moderate
risk of postoperative complicati
risk of postoperative complications.
«While we can't guarantee that the partners of
patients will not develop oral HPV infections or cancers, we can reassure them that our study found they had no increased prevalence of oral infections, which suggests their
risk of HPV - related oral cancer remains
low,» says Gypsyamber D'Souza, Ph.D., M.P.H., associate professor of epidemiology
at the Johns Hopkins University Bloomberg School of Public Health.
«We hope this tool will be widely adopted in emergency departments to identify
patients at high
risk of aneurysm while cutting wait times and avoiding unnecessary testing for
low -
risk patients,» says Dr. Perry.
Scientists
at Cedars - Sinai have developed a new way to identify which prostate cancer
patients are likely to develop aggressive types of the disease even if their tumors
at first appear to be
lower risk.
«In our study, individuals taking blood thinners were
at lower risk for heart attack from AF, suggesting a potential role for blood thinners in prevention of heart attacks in AF
patients.»
«
Lowering «bad» cholesterol (LDL) with an optimal intensity of tolerated statins and adherence to healthy lifestyle changes remains the most effective approach to prevent strokes and heart attacks for
patients at risk of cardiovascular disease.»
«Our analysis of a national dataset shows that the
risk for endophthalmitis is no higher with Avastin and hints that there may actually be a
lower endophthalmitis
risk compared to Lucentis, so the proposed FDA restrictions for Avastin might have the unintended consequence of increasing the infection
risk for
patients,» said senior author Brian L. VanderBeek, MD, MPH, an assistant professor of Ophthalmology
at Penn..
Based on these data, Ebell created a point score that can be used to determine the likelihood that a
patient is
at low, moderate or high
risk for bacterial infection.
People
at risk of stroke often take aspirin to reduce their
risk of having another stroke; however, a percentage of
patients may be insensitive, or resistant, to aspirin, which in turn may negate the aspirin's effect of
lowering stroke
risk.
Abdominal pain, which had been considered a
risk factor, turned out not to be one in this study —
patients at low -
risk may have complained of such pain.
A program developed
at Boston Medical Center (BMC), which integrates addiction treatment into primary care for
patients with or
at risk for HIV, has been shown to
lower patients» substance dependence and encourage their engagement in treatment.
«The factors we found that increase
risk of pancreatic cancer now allow us to separate
patients as either
low or high
risk,» says the study's senior author, Michael B. Wallace, M.D., MPH, a gastroenterologist
at Mayo Clinic.
The researchers believe that their software has the potential to help doctors to identify which of those
patients are
at low risk of suffering side effects and hence might benefit from treatment.
These medications can cause
patients» blood pressure to dip too
low (hypotension); elderly
patients are especially
at risk.
Transcatheter aortic valve replacement with a self - expanding valve prosthesis for the first time has demonstrated significantly
lower death rates
at one year compared with conventional surgical valve replacement in high -
risk patients with severe aortic stenosis, according to research presented
at the American College of Cardiology's 63rd Annual Scientific Session.
More than one - third of those
patients, for whom new American College of Cardiology / American Heart Association guidelines would recommend statin therapy, were reclassified as being
at very
low risk for cardiovascular disease.
Compared to currently approved treatment using an electrical cord connected
at an abdominal site, this new method has a
low risk of developing infectious diseases due to the power cable behind the ear and is anticipated to improve
patients» quality of life; for example,
patients with this new device can soak in a bathtub as most Japanese people do when taking a bath.
Twice - daily radiation might be worth considering in place of concurrent chemoradiotherapy for those
patients who are
at low risk for distant metastases and those
patients who can not tolerate systemic therapy.»
Patients with acute coronary syndrome undergoing coronary angiogram, a procedure used to assess blockages in the heart's arteries, had a significantly
lower risk of major bleeding and death if their interventional cardiologist accessed the heart through an artery in the arm rather than the groin, according to research presented
at the American College of Cardiology's 64th Annual Scientific Session.
A new study led by researchers
at Beth Israel Deaconess Medical Center (BIDMC) has found that
lower levels of vitamin D in the blood increase the
risk of clinical relapse in
patients with Ulcerative Colitis (UC), an inflammatory bowel disease that causes long - lasting inflammation and ulcers in the colon.
Patients who reported less than 150 minutes of moderate or vigorous physical activity still had a 33 percent
lower risk of 30 - day readmission compared to those who did not exercise
at all.
In 2009, practice leaders
at Mayo Clinic initiated a practice redesign effort targeted
at lower -
risk cardiovascular surgical
patients that would set clear expectations for their hospital care, improve
patients» experiences and outcomes, and reduce overall costs.
«This study demonstrates that Prosigna can reliably identify early stage breast cancer
patients who have a
low risk - of disease recurrence
at 10 years, including a substantial proportion of
patients with node - positive disease for whom the
risk / benefit derived for adjuvant chemotherapy would be
at best neutral,» said Dr. Alessandra Cesano, chief medical officer of NanoString Technologies.
The key factor: Nearly half of the
patients considered
at high
risk for recurrence might actually be
low risk based on genetic factors, researchers found.