Sentences with phrase «patients in the studies achieved»

All 19 patients in the study achieved some degree of remission after three months of treatment.

«This analysis shows that MRD - directed therapy clearly contributed to the unprecedented high rates of long - term survival that patients in this study achieved,» said first and corresponding author Ching - Hon Pui, M.D., chair of the St.Jude Department of Oncology.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Additional data from this study, also presented at The International Liver CongressTM today in Barcelona, Spain, show that 97 % of patients with the same HCV genotype, but without scarred livers, achieved SVR12 after eight weeks on the same treatment without ribavirin (RBV).

In addition, even after hospitals achieved a volume of 100 or so cases, there continued to be improvement in patient outcomes with higher procedure volume,» said John D. Carroll, M.D., professor of medicine and director of interventional cardiology at the University of Colorado Hospital and lead author of the studIn addition, even after hospitals achieved a volume of 100 or so cases, there continued to be improvement in patient outcomes with higher procedure volume,» said John D. Carroll, M.D., professor of medicine and director of interventional cardiology at the University of Colorado Hospital and lead author of the studin patient outcomes with higher procedure volume,» said John D. Carroll, M.D., professor of medicine and director of interventional cardiology at the University of Colorado Hospital and lead author of the study.

Results presented today at The International Liver Congress ™ 2015 demonstrate that hepatitis C (HCV)- infected genotype - 3 (GT - 3) patients, with and without cirrhosis, receiving 24 weeks of sofosbuvir (SOF) in combination with ribavirin (RBV) and peginterferon (PEG) achieved the highest sustained virologic response rates at 12 weeks (SVR12), observed in a Phase 3 study, to date.

The grant was to study what types of computational systems, in conjunction with physiological patient monitors, could be implemented into vehicles to achieve the safety objective.

In a single case study of one patient they achieved 36 % improvement in hand motor function in just 10 training sessions of 30 minutes eacIn a single case study of one patient they achieved 36 % improvement in hand motor function in just 10 training sessions of 30 minutes eacin hand motor function in just 10 training sessions of 30 minutes eacin just 10 training sessions of 30 minutes each.

In two studies appearing in the May 5 issue of JAMA, patients with chronic hepatitis C virus (HCV) genotype 1 infection and with or without cirrhosis achieved high rates of sustained virologic response after 12 weeks of treatment with a combination of the direct - acting - antiviral drugs daclatasvir, asunaprevir, and beclabuviIn two studies appearing in the May 5 issue of JAMA, patients with chronic hepatitis C virus (HCV) genotype 1 infection and with or without cirrhosis achieved high rates of sustained virologic response after 12 weeks of treatment with a combination of the direct - acting - antiviral drugs daclatasvir, asunaprevir, and beclabuviin the May 5 issue of JAMA, patients with chronic hepatitis C virus (HCV) genotype 1 infection and with or without cirrhosis achieved high rates of sustained virologic response after 12 weeks of treatment with a combination of the direct - acting - antiviral drugs daclatasvir, asunaprevir, and beclabuvir.

Elaine Mardis: In 2013 there were numerous studies [that provide] growing evidence that linking a patient's tumor genotype to a drug or drugs can achieve at least temporary remission.

In addition, many patients in the study required more than one ablation procedure to achieve freedom from atrial fibrillatioIn addition, many patients in the study required more than one ablation procedure to achieve freedom from atrial fibrillatioin the study required more than one ablation procedure to achieve freedom from atrial fibrillation.

The study results suggest that while training doesn't change neurological repair in chronic stroke patients, it can indeed help such patients learn new motor skills and achieve more independence in their daily lives.

«What makes these results especially encouraging is that they were achieved in patients who had exhausted other treatment options,» said the study's co-senior author, Margaret Shipp, MD, chief, Division of Hematologic Neoplasia at Dana - Farber.

Studies show that PD - 1 inhibitors are effective for a larger proportion of melanoma patients than ipilimumab alone — and, in combination with that drug, they achieve a two - year survival rate of 80 percent.

Among the evaluable patients in the newly reported phase II study, 23 (58 %) achieved complete response to the combination within four cycles, and 6 (15 %) had a partial response.

Rao, together with senior author Michael Brenner, set out to explore these questions by studying patient samples in remarkable detail not achieved in earlier studies.

«These studies provide promising evidence that autophagy blockade can be achieved, and that combining autophagy inhibitors with other cancer therapies in very sick patients can be accomplished safely in most cases.

In an Arthritis Care & Research study, Susan Goodman, MD, of the Hospital for Special Surgery and Weill Cornell Medical School, and her colleagues investigated the potential impact of weight on the likelihood that patients would achieve remission in the early years after an RA diagnosiIn an Arthritis Care & Research study, Susan Goodman, MD, of the Hospital for Special Surgery and Weill Cornell Medical School, and her colleagues investigated the potential impact of weight on the likelihood that patients would achieve remission in the early years after an RA diagnosiin the early years after an RA diagnosis.

If findings can be validated across multiple studies that are free of these limitations, then this approach could enable safe discharge of many more patients than is achieved in current practice.

In this study, researchers demonstrated that continued HIV replication in lymphoid tissue sanctuaries refills viral reservoirs in patients on ART who have achieved undetectable blood levels of HIIn this study, researchers demonstrated that continued HIV replication in lymphoid tissue sanctuaries refills viral reservoirs in patients on ART who have achieved undetectable blood levels of HIin lymphoid tissue sanctuaries refills viral reservoirs in patients on ART who have achieved undetectable blood levels of HIin patients on ART who have achieved undetectable blood levels of HIV.

The Aging Brain Care Medical Home, a novel population health management program implemented in the homes of older adults achieves significant health improvement for individuals with depression and also substantial stress reduction in family caregivers of dementia patients, according to a new study by investigators from the Regenstrief Institute, Indiana University Center for Aging Research and Eskenazi Health.

«Personalized cellular therapy achieves complete remission in 90 percent of acute lymphoblastic leukemia patients studied.»

Despite the allocation of all patients in this study to specific treatment, 48 of the 210 ongoing pregnancies (23 %) were achieved by natural conception.

The two ALS patients achieved 2.2 and 1.4 bits per second, respectively, more than doubling previous records (held by these same participants in a previous study from this group).

In fact, ACOs achieved meaningful improvements for patients in some key areas,» said lead author of the study J. Michael McWilliams, associate professor of health care policy and medicine at HMS and Brigham and Women's HospitaIn fact, ACOs achieved meaningful improvements for patients in some key areas,» said lead author of the study J. Michael McWilliams, associate professor of health care policy and medicine at HMS and Brigham and Women's Hospitain some key areas,» said lead author of the study J. Michael McWilliams, associate professor of health care policy and medicine at HMS and Brigham and Women's Hospital.

In the study of HBeAg - negative patients, 94 % (268 of 285) of patients receiving TAF and almost 93 % (130 of 140) of patients receiving TDF achieved the primary endpoint.

In the study of HBeAg - positive patients, almost 64 % (371 of 581) of patients receiving TAF and almost 67 % (195 of 292) of patients receiving TDF achieved the primary endpoint.

Study participation was restricted to patients with either ventricular fibrillation or ventricular tachycardia who did not achieve a stable heart rhythm after at least one defibrillator shock and, therefore, represent the typical group of those who receive such medications for cardiac arrest in clinical practice.

In this Phase 2a study, significantly more guselkumab - treated patients achieved ACR 20/50/70 responses and Psoriasis Area Severity Index (PASI) 75/90/100 responses at week 24.

A recent study by Drs. Thaler, O'Malley, Weinstein and other colleagues at Penn found that the TORS approach achieved a significant reduction in the apnea - hypopnea index (AHI)(an index used to assess the severity of sleep apnea), a significant improvement in minimum arterial oxygen saturation (the amount of oxygen in your blood that maintains healthy organ functioning), and a significant improvement in daytime drowsiness in patients.

«Our study shows that genotyping of CYP2C19 could be of considerable clinical value in individualising doses of escitalopram so that a better all - round antidepressive effect could be achieved for the patients,» says Professor Magnus Ingelman - Sundberg at Karolinska Institutet's Department of Physiology and Pharmacology who led the study together with Professor Espen Molden.

Of 24 patients who achieve complete response in this study, plus the 20 patients reported previously by our group, only two have developed recurrent melanoma at 19 and 27 months with a median potential follow - up of 53.4 months.»

Citing studies in cities where many more runs were canceled en route rather than resulting in treatment of patients, two academic physicians writing in the journal Neurology concluded it could be a «tall order» for MSUs to achieve a return on investment for individual health systems and communities.

(15) Another study reported benefit on overall symptoms scores, with 88 % of patients reported as achieving «mild - to - excellent improvement in IBS symptoms».

It is at present unknown whether an optimal balance between safety and efficacy can be achieved with the combination therapy of GH and IGF - I, since this combination has been evaluated in only a small number of patient populations and in studies of a relatively short duration.

In a recent trial for ulcerative colitis, a multicenter, randomized, placebo - controlled, double - blind study found that more than 50 percent of patients achieved remission within just one month on curcumin compared to none of the patients who received the placebo.

However, the effects of dietary fiber on glycemic control were considered inconsequential.1 Furthermore, the expert panel of the ADA considered it difficult to achieve a high dietary intake of soluble fiber without consuming foods or supplements fortified with fiber.1 We therefore designed the present study to determine the effects on glycemic control and plasma lipid concentrations of increasing the intake of dietary fiber in patients with type 2 diabetes exclusively through the consumption of foods not fortified with fiber (unfortified foods) to a level beyond that recommended by the ADA.

It is interesting that the significant weight loss using the intervention in this study was primarily seen in patients taking insulin, based on post hoc analyses, as it is notoriously difficult to achieve weight loss in patients using this anabolic hormone.

The herb hasn't proved effective in studies with canine cancer patients — it seems the doses given weren't enough to achieve the blood levels required to make an impact on the disease.

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Both the YPIC study and the adult Partners - in - Care Study52 achieved a roughly 10 percentage - point difference in the percentage of patients falling in the clinically significant range on the CES - D as well as achieving clinically meaningful improvements in mental health - related quality of life.

Over the years I have studied and trained in a number of modalities that can be integrated to help my patients achieve emotional, mental and physical balance.

The following hypotheses were tested: that the cognitive behaviour therapy would be superior to supportive counselling and routine care, and routine care alone, firstly, in reducing positive psychotic symptoms; secondly, in preventing the exacerbation of positive symptoms and reducing hospital stay; and, thirdly, by using the convention of the previous study of 50 % improvement in positive symptoms as an indicator of considerable clinical improvement, 6 in the number of patients achieving such improvement.

The aims of the analyses presented in this study were 1) to explore possible associations between the coping resources with achieved copying behaviors,... quality of life, pain - related factors and socio - demographic characteristics and 2) to identify patients with back pain who use different coping resources and to describe their respective socio - demographic and clinical characteristics.

The objective of this study was to determine if patients with diagnosed stage - 1 hypertension could benefit by a forgiveness training program to achieve measurable reductions in anger expression and blood pressure.