Sentences with phrase «patients in this large study»

Not exact matches

While the new mid-stage study results from DNDi were impressive (they showed cure rates of 96 % to 97 % even for the sickest patients and those with liver scarring), more late - stage trials will be necessary before the drug is available on a large scale in the developing world.

A large portion of the male and female patients enrolled in this outcomes study are anticipated to also be diagnosed with type 2 diabetes.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

«Power of Prayer Flunks Unusual Test — NEW YORK — In the largest study of its kind, researchers found that having people pray for heart bypass surgery patients had no effect on their recovery.

The conclusions of this British study of PVS, which is among the largest and most comprehensive available, echo the findings of an earlier U.S study of PVS patients referred to the Healthcare Rehabilitation Center in Austin, Texas.

He points to research by a Stanford University researcher, Allan K. Mishra, who has studied PRP for years, whose in his most recent published research includes a large multicenter study [8] involving a host of well - respected orthopedic surgeons around the country who followed 230 patients in a double - blind randomized control study [the gold standard for medical research].

A strength is that the study was performed in a large family practice teaching center, providing access to a wide spectrum of patients of various socioeconomic strata at one site.

«Previous studies have also noted that the financial condition of the most troubled institutions is, to a large extent, a product of an inefficient expense structure, revenue challenges associated with a patient mix that approaches 90 percent public payers and charity care, and overwhelming liabilities (including debt issued long ago for physical plant improvements that, in some cases, are obsolete),» the health department said in its announcement.

The study included 3 992 patients who had a cardiac arrest outside hospital in a large urban area and were treated by physician - based emergency medical services between 2002 and 2011.

A large study published last month in The Journal of the American Medical Association found that beta blockers did not prolong the lives of patients — a revelation that must have left many cardiologists shaking their heads (JAMA, vol 308, p 1340).

While further study of larger patient groups with longer follow - up times is needed for this cohort of prostate cancer patients, this study is pivotal in providing evidence for change in practice.»

In addition, rigorously designed studies of large and diverse patient samples are still needed to confirm the presence of these cytokine alterations, but if replicated, such findings could contribute to more personalized medicine for patients.

«This study demonstrates the value of using the SEER database to analyze factors associated with surgery as a treatment for localized pancreatic cancer in a large number of patients over a prolonged period of time,» says Dr. Kim, who is also Chief Medical Officer of UH Seidman Cancer Center and the Charles Hubay Professor at Case Western Reserve School of Medicine.

«We hope that our work will provide the basis for a larger study of patient samples that may ultimately identify biomarkers that can be used as surrogate markers to determine the benefit of therapeutic interventions in diagnosed but asymptomatic HD patients to prevent or delay disease onset.»

The researchers predict that the approach described in their study will pave the way to further develop the modelling of biomedical parameters and large - scale datasets in order to improve biological knowledge and patient outcome.

More studies will need to be done to confirm whether the results of the smaller studies are seen in larger groups of patients.

The largest urban health systems, which serve as safety nets for large patient populations with lower socioeconomic status and greater likelihood to speak English as a second language, do worse on government patient satisfaction scores than smaller, non-urban hospitals likely to serve white customers with higher education levels, according to a new study by Mount Sinai researchers published this month in the Journal of Hospital Medicine.

Patients can save about $ 5,600 a year in transportation and other related expenses by staying in their local hospital and avoiding transfer to a larger hospital elsewhere, the study found.

An associate professor of Neurology at Harvard Medical School, Talkowski adds, «Individuals in 10 countries — clinicians, investigators, patients and family members — helped us assemble the largest group of arhinia patients every studied, encompassing 24 percent of the previously reported 80 individuals and 21 newly identified patients.

This large study sponsored by the National Institute on Aging has been following 566 noncardiac surgical patients over the age of 70 for the past five years with the goal of finding new approaches to prevent delirium and its long - term consequences in older adults.

«Currently a majority of patients undergo colon resections for large polyps that don't harbor any cancer cells, which means in many cases a person's colon is being removed for noncancerous reasons, based on subjective criteria,» said lead study author Emre Gorgun, MD, FACS, FASCRS, a staff surgeon in the department of colorectal surgery, Cleveland Clinic, Ohio.

For example, the results of one study, known as UPLIFT, one of four large - scale studies conducted in 2008, demonstrated the effectiveness and safety of a drug called Spirivain about 6,000 patients with respiratory disease.

«If we can confirm these results in the larger study that we are planning to begin soon, this imaging system may allow us to personalize breast cancer treatment and offer the treatment that is most likely to benefit individual patients,» says Hershman, who is also a professor of medicine and epidemiology at Columbia University Irving Medical Center.

However, in the largest study of its kind so far, scientists from the German Cancer Research Center (DKFZ) in Heidelberg have now shown that the risk of death from heart disease in breast cancer patients following radiotherapy or chemotherapy is no higher than it is among the average population.

In designing their study, Mayo researchers used a large, multi-institutional database to identify a pool of 43,408 patients who underwent colorectal and liver resections for stage IV colorectal cancer.

The study — the largest to date assessing the mental and emotional health of patients with cancer using a fully standardized, diagnostic face - to - face interview — is published in the October 6 issue of the Journal of Clinical Oncology.

«This vaccine appears to be safe for patients, and elicits a broad anti-tumor immunity — we think it warrants further testing in larger clinical trials,» said study lead author Janos L. Tanyi, MD, an assistant professor of obstetrics and gynecology at Penn Medicine.

This large study contributes to the understanding of longer - term stroke risks in cardiac surgery patients.

«Researchers have done metabolic studies in patients with adrenal cancer, but they have looked at larger molecules, and they have targeted their investigations at specific steroids or gene profiles.

Our large cohort study confirms that these are also risky conditions for heart attack patients in the current era.»

He also began consulting on a large first - episode treatment program in four cities in Norway and Denmark, applying insights from earlier studies that had convinced him that combining multifamily psychoeducation, social services, and low - dose antipsychotics could prevent relapse among young, first - episode patients.

The large international study of 3,396 patients with venous thromboembolism in 31 countries shows, however, that rivaroxaban is more effective than aspirin.

The study was conducted at Parkland, the public health system for Dallas County, the ninth largest county by population and one of the most ethnically diverse counties in the U.S.. From Parkland's system of 10 neighborhood - based pediatric clinics, researchers identified four clinics with the largest volume of patients aged 11 to 18.

A large study of 108,711 patients who had cardiac surgery in Ontario, Canada, sought to identify risk factors for long - term stroke after surgery to improve outcomes for patients.

In the largest study of its kind, the researchers studied the long - term recovery (an average of 15 months) of 51 patients with Lyme disease - associated facial paralysis who sought follow - up care in the Facial Nerve Center at MassIn the largest study of its kind, the researchers studied the long - term recovery (an average of 15 months) of 51 patients with Lyme disease - associated facial paralysis who sought follow - up care in the Facial Nerve Center at Massin the Facial Nerve Center at Mass..

«The power of this study is that we looked at genes discovered to be over-expressed in patients» tumors and determined their function in kidney cancer, which has not been done on a large scale before,» he says.

«In this large observational study of patients with MS treated with AHSCT, almost half of them remained free from neurological progression for five years after transplant.

In the largest study of its kind, researchers found only 34 (0.31 %) healthy volunteers with serious adverse events, which are defined by the FDA as those that result in death; are life - threatening; require or prolong in - patient hospitalization; or cause a disability, congenital anomaly or birth defecIn the largest study of its kind, researchers found only 34 (0.31 %) healthy volunteers with serious adverse events, which are defined by the FDA as those that result in death; are life - threatening; require or prolong in - patient hospitalization; or cause a disability, congenital anomaly or birth defecin death; are life - threatening; require or prolong in - patient hospitalization; or cause a disability, congenital anomaly or birth defecin - patient hospitalization; or cause a disability, congenital anomaly or birth defect.

Studies show that PD - 1 inhibitors are effective for a larger proportion of melanoma patients than ipilimumab alone — and, in combination with that drug, they achieve a two - year survival rate of 80 percent.

A phase II basket study is ongoing to determine whether these early results can be confirmed in a much larger cohort of patients.

The Chronic Hepatitis Cohort Study is an analysis of records from a large, geographically and racially diverse group of 9,783 patients receiving care at four large U.S. health systems: Henry Ford Health System in Detroit; Kaiser Permanente Northwest in Portland, Oregon; Kaiser Permanente in Honolulu and Geisinger Health System in Danville, Pennsylvania.

«If these findings are confirmed in larger studies, they hold significant implications for new treatment targets and open the door for more questions such as: should these patients be treated more aggressively with medications, cognitive rehabilitation, or even surgery to open up the artery,» said Lal.

«While Massachusetts safety - net hospitals (many of which are minority - serving) received large cuts in payments with the idea that other hospitals would assume the care of previously uninsured patients, this study demonstrates the importance of securing the future of safety - net and minority - serving hospitals through policy - based interventions to assure the continued care of vulnerable and underserved patient populations.»

The researchers found five different sub-types of HL among the patients studied: 247 cases of the nodular sclerosis (NS) type, in which the tumour nodules are large; 105 of mixed cellularity, where a mixture of different types of inflammatory cells are involved; 58 lymphocyte rich, the sub-type with the best outcome; 68 «others»; and 143 «not otherwise specified» (NOS).

The small study, based on a survey of 236 cardiologists and internal medicine physicians and trainees at a large tertiary academic medical center, found that although physicians rate nutrition to be as important as statins in terms of reducing the risk of cardiovascular disease, only 13.5 percent agreed or strongly agreed that they were adequately trained to discuss nutrition with patients.

A large new study shows that only one in three patients who have the operation succeed in getting their body - mass index below 30, the cutoff for obesity, in the first year.

In the first study to report on the association of aspirin use with breast cancer outcomes in a large patient population, researchers examined the pattern of aspirin use, cancer pathology and overall survival in 1,000 patients treated at the Abramson Cancer Center of the University of Pennsylvania and diagnosed with breast cancers, including receptor positive, HER2 - positive and triple negative cancerIn the first study to report on the association of aspirin use with breast cancer outcomes in a large patient population, researchers examined the pattern of aspirin use, cancer pathology and overall survival in 1,000 patients treated at the Abramson Cancer Center of the University of Pennsylvania and diagnosed with breast cancers, including receptor positive, HER2 - positive and triple negative cancerin a large patient population, researchers examined the pattern of aspirin use, cancer pathology and overall survival in 1,000 patients treated at the Abramson Cancer Center of the University of Pennsylvania and diagnosed with breast cancers, including receptor positive, HER2 - positive and triple negative cancerin 1,000 patients treated at the Abramson Cancer Center of the University of Pennsylvania and diagnosed with breast cancers, including receptor positive, HER2 - positive and triple negative cancers.

Today, a study presented at the Annual Meeting of ESHRE provides strong evidence that freeze - all protocols are indeed associated with significantly improved IVF outcomes — especially in women over 35, a patient group rapidly becoming the largest and most challenging category of infertility patient.

In a landmark 1999 study, Harvard psychiatrist Andrew Stoll found that bipolar patients who were given large doses of omega - 3s did significantly better and resisted relapse longer than a matched group of patients who were given placebos.

The results of the trial — a combined phase 1 and 2 study — strongly support testing of the drug in a larger group of patients in both phase 2 and 3 trials, the authors say.