Sentences with phrase «patients in this study developed»

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While the new mid-stage study results from DNDi were impressive (they showed cure rates of 96 % to 97 % even for the sickest patients and those with liver scarring), more late - stage trials will be necessary before the drug is available on a large scale in the developing world.

The study participants were asked to develop strategies for landing the rocket mentally; this, in turn, allowed the patients to strategize ways of blocking out hallucinatory voices inside their heads.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Juno is developing its immunotherapy product candidate, JCAR017, which is in a Phase I trial, studying patients with B - cell Non-Hodgkin Lymphoma [NHL].

Chimerix, a biopharmaceutical company that develops antivirals in areas of high unmet medical need, announced in a press release that a Phase 3 study for its SUPPRESS of brincidofovir in patients undergoing...

To conduct the study, researchers developed an online survey that asked participants to respond, true or false, to whether they believed it is acceptable to allow a physician to prescribe medication, at the request of a terminally - ill patient, in order to end that person's life.

Ongoing studies at Uppsala University in Sweden have shown that the chemical agent dubbed Pittsburgh Compound - B, or PIB, is a highly accurate marker of plaque buildup and that its abundance in the brain can predict whether patients with mild cognitive impairment will develop Alzheimer's — and when that decline will likely start.

However, the majority of patients develop treatment - resistant tumors, and only 10 to 15 percent of these patients survive long term, says Ie - Ming Shih, M.D., Ph.D., the Richard W. TeLinde Distinguished Professor in the department of Gynecology and Obstetrics, who led the study with Tian - Li Wang, Ph.D., an associate professor of pathology and oncology at the Johns Hopkins University School of Medicine.

To study the pathogenesis of HIV - induced PNS disease, Jamie Dorsey, Research Technologist, and the research team led by Dr. Mankowski developed a simian immunodeficiency virus (SIV)- infected macaque model that closely reflects key peripheral nervous system (PNS) alterations seen in HIV patients with peripheral neuropathy.

Led by Stella K. Kang, a radiologist with the Department of Radiology at the New York School of Medicine, the study was designed to compare the effectiveness of a treatment algorithm for small renal tumors incorporating the nephrometry score, a renal tumor anatomy scoring system developed by urologists, with the current standard of uniformly recommended partial nephrectomy in patients with mild - to - moderate chronic kidney disease (CKD).

A recent study published in Annals of Neurology reports that healthy human tissue grafted to the brains of patients with Huntington's disease in the hopes of treating the neurological disorder also developed signs of the illness, several years after the graft.

However, in this study all patients who developed TR often had tricuspid annulus diameters less than 40 mm, as well as less than moderate TR by echocardiography at the time of the MV repair.

In this study in a Berlin hospital, one patient in five receiving routine care suffered from postoperative delirium, whereas in the group receiving support from delirium liaison nurses, fewer than 1 in 20 developed cognitive disorderIn this study in a Berlin hospital, one patient in five receiving routine care suffered from postoperative delirium, whereas in the group receiving support from delirium liaison nurses, fewer than 1 in 20 developed cognitive disorderin a Berlin hospital, one patient in five receiving routine care suffered from postoperative delirium, whereas in the group receiving support from delirium liaison nurses, fewer than 1 in 20 developed cognitive disorderin five receiving routine care suffered from postoperative delirium, whereas in the group receiving support from delirium liaison nurses, fewer than 1 in 20 developed cognitive disorderin the group receiving support from delirium liaison nurses, fewer than 1 in 20 developed cognitive disorderin 20 developed cognitive disorders.

To address the complexity of the biologic pathways that create and respond to pressure sore development, the researchers designed a computational, or «in silico,» model of the process based on serial photographs of developing ulcers from spinal cord - injured patients enrolled in studies at Pitt's Rehabilitation Engineering Research Center on Spinal Cord Injury.

Mice transplanted with cells grown from a patient suffering from Huntington's disease (HD) develop the clinical features and brain pathology of that patient, suggests a study published in the latest issue of Acta Neuropathologica by CHA University in Korea, in collaboration with researchers at Université Laval in Québec City, Canada.

Prior to the new study, researchers had already developed a more basic type of skin substitute that had been used successfully in human patients, said Takashi Tsuji, a team leader at RIKEN Center forDevelopmental Biology in Japan.

The researchers predict that the approach described in their study will pave the way to further develop the modelling of biomedical parameters and large - scale datasets in order to improve biological knowledge and patient outcome.

Based on their results, Gigi Ebenezer, M.B.B.S., M.D., assistant professor of neurology and the first author on the study, reported that protein clumps were detected in 70 percent of cases and 20 percent of patients who carried disease - causing genes but hadn't yet developed symptoms.

In the study, Litt's team at MU Health Care used a recently developed autograft harvesting system to care for 13 patients with various types of chronic wounds.

The study published in the journal Schizophrenia Bulletin reports preliminary results showing that a blood test, when used in psychiatric patients experiencing symptoms that are considered to be indicators of a high risk for psychosis, identifies those who later went on to develop psychosis.

In a study recently published in the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxiIn a study recently published in the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxiin the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxiin collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxiin mice, an approach they hope will make blood stem cell transplants for these patients far less toxic.

Brain - imaging studies have shown that most patients with frontotemporal dementia who develop skills have abnormally low blood flow or low metabolic activity in their left temporal lobe.

One in four patients develop heart failure within four years of a first heart attack, according to a study in nearly 25,000 patients presented today at Heart Failure 2016 and the 3rd World Congress on Acute Heart Failure by Dr Johannes Gho, a cardiology resident at the University Medical Center Utrecht, in Utrecht, the Netherlands.1 Risk factors included older age, greater socioeconomic deprivation, and comorbidities such as diabetes.

«One criticism of the PARP drugs is they are not active in patients who have developed resistance to other therapies, but we found veliparib appears to be effective in some platinum - resistant patients with recurrent or persistent disease,» said Robert L. Coleman, MD, lead author of the study and professor and vice chair of clinical research at the University of Texas MD Anderson Cancer Center, Houston.

In this study, published in the October 31 issue of the Proceedings of the National Academy of Sciences, Sudhir Yadav PhD, a neuroimmunology post-doctoral fellow in the laboratories of Drs. Kouichi Ito, associate professor of neurology, and Suhayl Dhib - Jalbut, professor and chair of neurology, tested mice that were engineered to have a pre-disposition for MS. Because mice would not normally develop MS, researchers used MS - associated risk genes from real patients to genetically engineer mice for this studIn this study, published in the October 31 issue of the Proceedings of the National Academy of Sciences, Sudhir Yadav PhD, a neuroimmunology post-doctoral fellow in the laboratories of Drs. Kouichi Ito, associate professor of neurology, and Suhayl Dhib - Jalbut, professor and chair of neurology, tested mice that were engineered to have a pre-disposition for MS. Because mice would not normally develop MS, researchers used MS - associated risk genes from real patients to genetically engineer mice for this studin the October 31 issue of the Proceedings of the National Academy of Sciences, Sudhir Yadav PhD, a neuroimmunology post-doctoral fellow in the laboratories of Drs. Kouichi Ito, associate professor of neurology, and Suhayl Dhib - Jalbut, professor and chair of neurology, tested mice that were engineered to have a pre-disposition for MS. Because mice would not normally develop MS, researchers used MS - associated risk genes from real patients to genetically engineer mice for this studin the laboratories of Drs. Kouichi Ito, associate professor of neurology, and Suhayl Dhib - Jalbut, professor and chair of neurology, tested mice that were engineered to have a pre-disposition for MS. Because mice would not normally develop MS, researchers used MS - associated risk genes from real patients to genetically engineer mice for this study.

The H5N1 avian influenza strain developed strong resistance to oseltamivir, better known as Tamiflu, in two Vietnamese patients who died from the virus early this year, according to a new study.

Sharma had developed a new method for studying how tumors with different characteristics respond to different immunotherapies: She would treat patients before their growths were surgically removed, then analyze the tissue in her lab.

The imaging software — developed and currently in use only at Cincinnati Children's — mathematically determines the lowest possible radiation dose for the patient before a scan is performed, according to the study led by David Larson, MD, radiology quality and safety director at the medical center and principal architect of the technology.

A multi-institutional study led by a Massachusetts General Hospital (MGH) investigator finds significant racial disparities in the risk that patients being treated for gout will develop a serious, sometimes life - threatening adverse reaction to the most commonly prescribed medication.

The study, Developing an Interventional Stroke Service: Improving Clinical Outcomes and Reducing Cost and Delivering Great Cost Savings Benefits to Health Economy, conducted at the University Hospital of North Midlands, Stoke - on - Trent, U.K., found that mechanical thrombectomy (the use of a device to retrieve a clot from the vessel) in the treatment of stroke reduced the average stroke patient's hospital stay to 14 days when compared to previously recorded 90 days.

Scientists want to be able to clone early human embryos, using cells from patients with various diseases, so they can study the diseases in the lab and develop new treatments for them.

About 40 percent of patients in their study who developed pneumonia from any viral infection died.

Patients in the study were those at highest risk for developing chronic pain and persistent high - dose opioid use after major surgery.

White and colleagues will work with other collaborators at the Cancer Institute to develop early - phase patient clinical trials based on the findings from this study in the near future.

Future studies may also reveal which stroke patients are more likely to develop pneumonia or disruptions in heart rhythm.

«If you look at a set of lung cancer patients, like we did in the paper, who develop brain metastases, they all have those two genes in their primary lung cancer,» said Sheila Singh, the study's supervisor, associate professor at the Michael G. DeGroote School of Medicine, scientist with the Stem Cell and Cancer Research Institute at McMaster University and neurosurgeon at McMaster Children's Hospital.

In this new study, they looked at cancer risk in patients who developed heart failure after their first heart attacIn this new study, they looked at cancer risk in patients who developed heart failure after their first heart attacin patients who developed heart failure after their first heart attack.

«We found one in three TIA patients develop PTSD,» said Kathrin Utz, Ph.D., a study author and post-doctoral researcher in the Department of Neurology at the University of Erlangen - Nuremberg in Germany.

The first long - term study of a pioneering endoscopic laser treatment for early vocal - cord cancer, developed at Massachusetts General Hospital (MGH) and previously shown to provide optimal voice outcomes, finds that it is as successful as traditional approaches in curing patients» tumors while avoiding the damage to vocal quality caused by radiotherapy or by conventional laser or cold - instrument surgery.

Dr Brian Bigger, Chief Scientific Investigator for the study from The University of Manchester said: «It is fantastic to see a treatment we developed at The University of Manchester, in collaboration with clinicians, reach the point where we can test its effectiveness in patients.

The exact mechanisms must be probed in further animal studies, Reid says, but eventually he hopes researchers will be able to use a patient's bacterial makeup as a biomarker for cancer screening or to develop probiotics for improving prognosis and treatment outcomes.

New findings from large - scale studies of more than 3.6 million people who underwent screening for cardiovascular disease reveals that a person's age and gender affects the prevalence of certain types of peripheral vascular diseases (PVD), and that diabetes is a major risk factor for developing these diseases, even in patients without heart disease.

In the study, patients used an iPad - based application, developed by Mukamel and the research team.

The study's conclusions address a major challenge in current standards of care for prostate cancer: Without knowing a tumor's underlying biology, physicians can not reliably predict which of their patients will develop dangerous forms of the disease.

The study shows that patients suffering from RBD have a risk of developing Parkinson's disease or dementia in the future, because they already suffer from a lack of dopamine in the brain.

Foy said the study also underscores the importance of treating obesity in patients regardless of whether they've developed complications.

The study reflects an «antimicrobial stewardship» approach, guiding healthcare providers to prescribe the most appropriate antibiotic for a patient's specific type of infection, with the aim of improving individual outcomes and reducing the overall risk of antibiotic resistance — in which disease - causing microorganisms develop resistance to commonly used antibiotics.

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

Tremor - dominant patients are also less likely to develop dementia, although this symptom was not assessed in the study.

The assay was developed using detailed patient samples from Harris's collaborative studies in Nicaragua, a large step forward over previous studies.