The NYGC and its founding member institutions are conducting additional studies involving Watson to help accelerate the discovery of potentially actionable sequence variants in various types of cancer, including an ongoing study that involves DNA and RNA from a larger cohort of glioblastoma patients, and a study of 200
patients with different types of cancer.
Answering important clinical questions — such as whether genetic diversity is a risk factor for aggressive tumor development or how it relates to treatment resistance — requires analyzing samples from many
patients with different types of cancer.
Not exact matches
Cancer is a heterogeneous disease,
with genetic variations occurring between
different types of tumors and
different patients.
Surprisingly, they found that although the patterns
of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver
cancers with biliary phenotype and depended on the histological
type, the overall pattern
of mutations in the cells was actually similar between the tumors —
of either
type — that had emerged in
patients who had had infections
with either hepatitis C or B, and were
different in
patients without such infections.
Researchers leading the largest genomic tumor profiling effort
of its kind say such studies are technically feasible in a broad population
of adult and pediatric
patients with many
different types of cancer, and that some
patients can benefit by receiving precision drugs targeted to their tumors» mutations or being enrolled in clinical trials.
The activation
of this signaling pathway progressively increased in
different types of gliomas,
with the highest activity seen in
patients with glioblastoma, a particularly difficult - to - treat form
of brain
cancer that represents approximately 15 percent
of all brain tumors.
Studying
cancer with single - cell technology will allow us to unlock the interactions between
different types of cells in tumors — and monitor how these interactions change over time, affecting
patients» outcomes.
Sometimes, two
patients with the same
type of cancer may be dealt
different prognoses depending on their genetic mutations.
Chief among them is creation
of a huge database
of diagnostic and treatment information from all
cancer patients that clinicians and researchers would use to study
different disease
types and respond
with specially targeted drugs.
Because the region
of chromosome 5p15 is
of interest in
cancer biology, the deCODE team then tested this SNP for association
with 16
different types of cancer in a total
of nearly 80,000
cancer patients and healthy control subjects from Iceland, the Netherlands, Italy, Sweden, Spain, Germany, Hungary, the United Kingdom, Belgium, Romania, Slovakia and the United States.
We see
patients with all manner
of disease due to a compromised immune system like recurrent cough and colds, skin infections, recurrent allergies, autoimmune diseases and many
different types of cancers.