So that's another myth busted... the official first line intervention for
patients with high cholesterol is not statin drugs... it's diet change... and that's official!
It is because of the known benefits of good diet that Doctors are encouraged to follow best practice guidelines which state
that patients with high cholesterol must first be advised to modify their diet and lifestyle in an effort to lower cholesterol to the desired range.
A phase 2 clinical trial recruited 497
patients with high cholesterol, 73 percent of which were already taking statins, the current standard treatment for those at risk of cardiovascular disease.
A doctor of naturopathic medicine and a chiropractor, Dr. King found that
his patients with high cholesterol who were not being aided by the drugs for that condition were helped by making bison their primary red meat source.
Not exact matches
Herper homes in on a relatively new class of super-powerful (and super expensive)
cholesterol - busting drugs called PCSK9 inhibitors (which were just shown to reduce death from any cause, and particularly heart - related conditions), and how
patients with staggeringly
high cholesterol who would benefit from the treatments had to wrangle
with insurance companies that refused to cover them over their
high prices.
High triglycerides increase cardiovascular events, medical costs, and resource utilization in a real - world analysis of statin - treated patients with high cardiovascular risk and well - controlled low - density lipoprotein cholesterol [abstra
High triglycerides increase cardiovascular events, medical costs, and resource utilization in a real - world analysis of statin - treated
patients with high cardiovascular risk and well - controlled low - density lipoprotein cholesterol [abstra
high cardiovascular risk and well - controlled low - density lipoprotein
cholesterol [abstract].
PCSK9 inhibitors, the main ingredients in Amgen's Repatha and Sanofi and Regeneron's Praluent treatments, were first approved by the Food and Drug Administration in July 2015 for use by
patients with a family history of
high cholesterol or those who suffered
high -
cholesterol - induced heart attacks.
Researchers from Aston Medical School in Birmingham looked at more than 900,000
patients with high blood pressure,
high cholesterol and type 2 diabetes and found marriage led to
higher survival rates.
I was quite fascinated by that and in that process, I started providing my
patients with bison meat and saw it was lowering their
high cholesterol and triglycerides.
A new study shows that the drug fenofibrate might reduce the risk of cardiovascular events in
patients with type 2 diabetes who have
high levels of triglycerides and low levels of «good»
cholesterol, despite being treated
with statins.
The findings suggest that fenofibrate therapy may be beneficial in the way the researchers hoped: by reducing cardiovascular events in
patients with type 2 diabetes who take statins but still have especially
high triglycerides levels and low HDL
cholesterol levels.
Bococizumab significantly reduces cardiovascular events in
high - risk
patients with high LDL
cholesterol levels.
Inclisiran lowers low - density lipoprotein (LDL; «bad»)
cholesterol for up to one year in
patients with high cardiovascular risk and elevated LDL
cholesterol, according to late - breaking results from the ORION 1 trial presented today in a Hot Line LBCT Session at ESC Congress.
The trial included 501
patients with atherosclerotic cardiovascular disease (ASCVD) and elevated LDL
cholesterol (> 70mg / ml) despite maximum tolerated statin therapy and
patients without ASCVD but
with high cardiovascular risk conditions such as diabetes and familial hypercholesterolaemia in whom LDL
cholesterol was > 100mg / dl despite maximally tolerated statin therapy.
The researchers therefore believe that the cognitive problems can be explained to a
high degree by the risk factors that are common to
patients with different types of heart complaint, for example diabetes,
high blood pressure and
high cholesterol.
In preclinical studies using cell models that mimicked liver cells of
patients with the rare disease Friedreich's ataxia (FA), a widely used
cholesterol - lowering drug increased a precursor of HDL (
high - density lipoprotein), the «good
cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.
An example comes from a
patient with familial hypercholesterolemia — a disease that causes
high blood levels of «bad» LDL (low - density lipoprotein)
cholesterol because a cellular defect prevents the liver from absorbing LDL.
«
Patients with higher LDL
cholesterol levels are likely to experience even greater health benefits from taking statins and some of the newer
cholesterol drugs.»
«They were not developed for cancer, they were manufactured for people
with hypercholesterolemia [chronic condition where
patients have very
high level of
cholesterol in their blood], but it will be interesting for us to test them
with cancer
patients and see if there is improvement.»
Unmarried individuals were more likely to be female and black, have hypertension, heart failure, or
high cholesterol and less likely to be smokers compared
with the married
patients.
Among type - 2 diabetic
patients with an elevated risk of cardiovascular disease — those
with high levels of triglycerides and low levels of «good»
cholesterol (
high - density lipoprotein or HDL)-- fenofibrate cut adverse cardiovascular outcomes by 30 per cent in women and 24 per cent in men.
Dr Nakano said: «Many randomised clinical trials, such as Treating to New Targets (TNT) and PROVE IT - TIMI, have shown that aggressive
cholesterol lowering
with statins improves clinical outcomes in
patients with CAD and
high LDL - C levels.1, 2 But until now it was not known whether aggressive lipid lowering
with statins would also benefit CAD
patients with very low LDL - C levels.»
However, Abraham's team found that IBD
patients diagnosed at an older age (e.g., 45 instead of 35), those
with metabolic syndrome risk factors (diabetes, hypertension, obesity, and
high cholesterol), and most importantly, those
with longer duration of disease regardless of age at diagnosis, are more likely to develop NAFLD.
Two other vignettes consider other issues raised by a 78 - year - old
patient with dementia and an abnormal heart rhythm, and the value of screening tests for
high cholesterol or colon cancer in a 69 - year - old
patient with dementia.
5/21/2008
Patients Find Relief from Liver Disease
with Minimally Invasive Surgery at Moores UC San Diego Cancer Center At 66, Donald Fuhrman, a retired real estate broker and investor, looked like many men his age: enjoying world travel and in good health
with just slightly
high cholesterol.
Pro12Ala polymorphism in the peroxisome proliferator - activated receptor - γ2 (PPARγ2) is associated
with higher levels of total
cholesterol and LDL -
cholesterol in male caucasian type 2 diabetes
patients
PHILADELPHIA — In preclinical studies using cell models that mimicked liver cells of
patients with the rare disease Friedreich's ataxia (FA), a widely used
cholesterol - lowering drug increased a precursor of HDL (
high - density lipoprotein), the «good
cholesterol,» according to new research published in PLOS One from the Perelman School of Medicine at the University of Pennsylvania.
According to a recent editorial in JAMA Cardiology, a disproportionate number of young
patients with high LDL
cholesterol — 50 % — do not take their prescribed statins.
Zachary T. Bloomgarden, MD, an endocrinologist at Mount Sinai School of Medicine in New York City who specializes in diabetes, prescribes these drugs to most of his
patients, particularly those
with hypertension, cardiovascular disease, or risk factors for heart disease, such as
high cholesterol.
The authors found that those
with lower LDL -
cholesterol and triglyceride levels had a significantly elevated mortality risk when compared to
patients with higher LDL and triglyceride levels.
In a study of 333 individuals at Sahlgrenska Hospital in Sweden, Dr. B.A. Bengtsson found that
patients with growth hormone deficiency frequently had
high LDL (bad)
cholesterol and low HDL (good)
cholesterol levels.
The investigators also looked at a subgroup of
patients with familial hypercholesterolemia, a genetic disorder that causes extremely
high cholesterol that increases the risk of early heart disease.
Another article from 2004 measured changes in
cholesterol levels in 83 obese
patients with known
high cholesterol and
high glucose.
For example, she has seen dramatic results for
patients with type 2 diabetes,
high cholesterol and
high blood pressure who go on a whole - food, plant - based diet.
In this study of 12
patients with elevated LDL
cholesterol levels, a diet containing almonds and other nuts, plant sterols (also found in nuts), and soluble fiber (in
high amounts in beans, oats, pears) reduced blood levels of all LDL fractions including small dense LDL (the type that most increases risk for cardiovascular disease)
with near maximal reductions seen after only 2 weeks.
In fact,
high cholesterol levels later in life are associated
with reduced risk of dementia, and the CSF of AD
patients has been shown to be lower in
cholesterol than that of healthy controls.62, 63 HMG CoA reductase — the target of statin therapy — is abundant in brain cells.
Repeated infrared sauna treatments improved impaired blood vessel functions in
patients with high blood pressure, diabetes and
high cholesterol.
This study discovered administering T4 to
patients with «
high - normal» TSH (2 - 4 uIU / mL) lowered their
cholesterol, supporting the existence of a subclinical hypothyroidism
with tangible harms, and numerous citing papers argue for a narrower reference range.
Half of female
patients with hair loss have a constellation of signs and symptoms related to insulin resistance, blood sugar abnormalities,
high blood pressure, and abnormal
cholesterol.
I saw another
patient who, except for a little bit of extra weight, was healthy until she was diagnosed
with high total
cholesterol levels.
I can't believe VCL is not prescribed to all
patients with diabetes, PCOS,
high cholesterol, etc..
In this study of 12
patients with elevated LDL
cholesterol levels, a diet containing almonds and other nuts, plant sterols (also found in nuts), soy protein, and soluble fiber (in
high amounts in beans, oats, pears) reduced blood levels of all LDL fractions including small dense LDL (the type that most increases risk for cardiovascular disease)
with near maximal reductions seen after only 2 weeks.
Magnesium deficiency also leads to elevated blood sugar and
cholesterol, so
high blood pressure
patients often end up
with these conditions as well.
There are also studies showing that
patients with higher levels of HDL
cholesterol have lower levels of inflammatory chemicals in their bloodstream, so that could explain it.
This is seen in data where the percentage of
patients with and without CAD who have
high cholesterol,
high blood pressure, and other surrogate outcomes is not 100 % and 0 %, respectively (45, 46).
(I have read the studies that equate
high LDL levels
with heart disease, but I am also aware that for many of these
patients the standard of care is to first address diet and exercise before
cholesterol - lowering drugs are used.
I use Guggul
with patients only if they appear to need thyroid support and have blood sugar on the
high side, because Guggul can address both, and achieving balance like this appears to reduce LDL
cholesterol levels (it's known, of course, that low thyroid activity causes blood
cholesterol to rise, and I couldn't agree more that hypothyroidism is seriously under - diagnosed).
If the
cholesterol and triglycerides are too
high, then the
patient is returned to the primary care DVM
with the aim of reducing the lipids preoperatively as their elevation can predispose the
patient to lipemic aqueous syndrome (LAS) which can irreversibly damage an otherwise successful postoperative outcome.
If you have
high cholesterol your aortic stenosis can go from mild to terrible 200 % faster than a
patient with normal
cholesterol.
'' Work
with a broker who specializes in obtaining life insurance for heart
patients and other
high risk individuals, such as people
with high cholesterol or cancer..