Sentences with phrase «patients with low levels»

Among 128 of the 141 patients, the scientists found that the median progression - free survival of 71 patients identified with high levels of cancer DNA in their blood was 2.1 months, compared with 5.8 months for 57 patients with low levels.

Additionally, lung cancer patients who have high levels of YAP1 in their tumors are more likely to have a poorer prognosis than patients with low levels of YAP1.

But in patients with the lowest levels of BDNF, symptoms still lingered at follow - up.

Despite also having more severe head and systemic injuries, patients with lower levels of hemoglobin had a poor outcome.

Using data from a large public brain tumor database called REMBRANDT, the researchers confirmed that patients with lower levels of SND1 survived longer than those with elevated SND1 expression.

Patients with a lower level of education were also less likely to understand the concepts pre - and post-visit but did show benefit from the counseling sessions, leading investigators to recommend exploring strategies to enhance the teaching tools used for people with the lowest education levels.

Not exact matches

After studying numerous patients with circadian rhythms out of sync, he hypothesized that their adrenal glands were overworked and producing lower levels of the hormones needed to cope with stress.

REDUCE - IT is the first multinational cardiovascular outcomes study evaluating the effect of prescription pure EPA therapy, or any triglyceride - lowering therapy, as an add - on to statins in patients with high cardiovascular risk who, despite stable statin therapy, have elevated triglyceride levels (150 - 499 mg / dL).

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

In 2006, scientists evaluated the effects of vitamin D on the mental health of 80 elderly patients and found those with the lowest levels of vitamin D were 11 times more prone to be depressed than those who received healthy doses.

Patients with major depression often have low levels of vitamin E in their blood.

Lower levels of light: As shadows increase and light levels begin to fall, patients with already bad eyesight can find themselves struggling to focus their vision even more — leading to frustration and anger

A new study shows that the drug fenofibrate might reduce the risk of cardiovascular events in patients with type 2 diabetes who have high levels of triglycerides and low levels of «good» cholesterol, despite being treated with statins.

The findings suggest that fenofibrate therapy may be beneficial in the way the researchers hoped: by reducing cardiovascular events in patients with type 2 diabetes who take statins but still have especially high triglycerides levels and low HDL cholesterol levels.

Associate professor Mary - Ellen Taplin, of the Dana - Farber Cancer Institute, Boston, USA, will tell the 26th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain, that galeterone was well tolerated by patients in the ARMOR2 trial, and also lowered PSA levels in a subset of men with CRPC that was resistant to other drugs that target the cancer, such as enzalutamide and abiraterone.

The results of the study show that more than half of the patients with bipolar disorder who had elevated or low levels of cortisol in the blood, also had depression.

Metformin, a commonly used drug for treating type 2 diabetes, is linked to an increased risk of low thyroid - stimulating hormone (TSH) levels in patients with underactive thyroids (hypothyroidism), according to a study in CMAJ (Canadian Medical Association Journal).

Support for this hypothesis was seen in the group with bipolar patients where older patients exhibited lower cortisol levels especially among patients that throughout life had been without prophylactic mood stabilizing treatment.

Martin Maripuu, doctoral student at the Department of Clinical Sciences, Division of Psychiatry, has studied the correlation between low cortisol levels, so - called hypocortisolism, and poor psychiatric and somatic health in patients with recurrent depressions or bipolar disorder.

Through their analysis the researchers detected damaged proteins in characteristic patterns in the samples of those patients with early and advanced OA and RA, but were found at markedly lower levels in the samples of those in the control group — providing the researchers with the identifiable biomarkers necessary for early detection and diagnosis.

The report — the most - detailed examination of medical marijuana and opioid deaths conducted to date — found that legalizing medical marijuana was associated with lower levels of opioid deaths only in states that had provisions for dispensaries that made medical marijuana easily available to patients.

In patients with treated hypothyroidism, metformin monotherapy was associated with a 55 % increased risk of low TSH levels compared with treatment with sulfonylurea.

The results showed that patients with diabetes had substantially lower levels of substance P in tear film samples, compared to healthy controls.

Overall, Blair maintains that the potential benefits to FA patients with low ApoA - I levels taking low doses of statins outweigh the potential risks.

The next step of the research, conducted in collaboration with David Lynch, MD, PhD, a professor of Neurology at Children's Hospital of Philadelphia (CHOP), showed that statins may be able to help Friedreich's ataxia patients increase their naturally low ApoA - I levels and so increase their HDL levels, which might help prevent heart disease.

Analyzing a database of nearly 800 multiple myeloma patient samples, they discovered that 162 patients with low ADAR1 levels in their tumor cells survived significantly longer over a three - year period compared to 159 patients with high ADAR1 levels.

Patients with Parkinson's disease also suffer from very low dopamine levels.

Abiraterone's ability to lower levels of prostate - specific antigen, a surrogate marker for prostate cancer, was slightly greater for patients in the low - dose with food group when measured at 12 weeks.

Primarily supported by a $ 5.6 million grant from the The Michael J. Fox Foundation for Parkinson's Research and conducted at 17 sites across the U.S., SURE - PD (Safety of URate Elevation in Parkinson's Disease) enrolled 75 recently diagnosed Parkinson disease patients with relatively low blood levels of urate (less than 6 mg / dL).

An example comes from a patient with familial hypercholesterolemia — a disease that causes high blood levels of «bad» LDL (low - density lipoprotein) cholesterol because a cellular defect prevents the liver from absorbing LDL.

Researchers say further study is needed using individual patient - level data among men with high risk prostate cancer to assess the benefit of HRT and whether treatment toxicity, particularly those to the bladder and urinary system are also low with HRT.

«These studies set the stage for newer approaches to lower the levels of these lipids in patients with Gaucher disease and others with precursors for myeloma.

The largest urban health systems, which serve as safety nets for large patient populations with lower socioeconomic status and greater likelihood to speak English as a second language, do worse on government patient satisfaction scores than smaller, non-urban hospitals likely to serve white customers with higher education levels, according to a new study by Mount Sinai researchers published this month in the Journal of Hospital Medicine.

Furthermore, the levels of Runx2 expression among a larger group of 351 newly diagnosed multiple myeloma patients were significantly higher in patients who had a high risk of early disease - related death, as compared with lower - risk patients.

The researchers then discovered that patients with celiac disease had unusually low levels of lnc13 in their intestines, suggesting that downregulation of this gene may contribute to the inflammation seen in celiac disease.

The PPN was of interest because, in previous studies, patients with Parkinson's disease displayed lower levels of mitochondrial DNA (mtDNA) in remaining dopaminergic neurons.

An analysis of ZMYND11 levels in the tumors of 120 triple - negative breast cancer patients showed that those with high levels of the protein had an 80 percent probability of surviving for 10 years while those with low levels had a 50 percent probability.

The study builds on previous findings suggesting that AIM2 limits cancer cell growth in colon cancer cell lines, Wilson said, as well as on a clinical report of poor prognosis in colon cancer patients with low or missing AIM2 levels.

Patients with low testosterone levels who have then gone on to have testosterone replacement therapy (TRT) could be at lower risk of cardiovascular events such as heart attack or stroke, according to research published in the European Heart Journal.

In GBM patients, PRMT5 expression levels in tumor were significantly associated with lower overall survival;

The team therefore analyzed the case history of 890 breast cancer patients and found that low Numb - 1 and -2 levels correlated with an increased risk of aggressive, metastatic disease, particularly for the luminal subtype of breast cancers, which tend to retain a normal, functional copy of the p53 gene.

Patients with values lower than 10 mg / dl had a near two-fold increased rate of coronary atherosclerosis as compared with those showing normal levels.

While the number of patients with a heavy asbestos load was reduced compared with previous years, the incidence of low to medium levels was unchanged.

A study of patients in the United Kingdom suggests widespread prescribing of the medication levothyroxine sodium to boost thyroid function among patients with borderline high levels of the thyroid - stimulating hormone thyrotropin (a sign of low thyroid function), raising the possibility of overtreatment, according to a study published by JAMA Internal Medicine, a JAMA Network publication.

Vitamin D deficiency was associated with higher prevalence of coronary artery disease, with a 32 percent higher occurrence in patients with the lowest vitamin D levels and a near 20 percent higher frequency of severe disease affecting multiple vessels.

«We would give this biologic — which has minimal side effects — to any patient we identify through a blood test as producing HE4,» he says, adding that oncologists have recognized that women with high levels of HE4 do not respond to treatment and their survival rates are lower.

That paper reported that two - thirds of Type 2 diabetic men with chronic kidney disease have low testosterone levels and that among patients on dialysis, a remarkable 90 percent have low testosterone.

Although several large studies have shown that α - synuclein levels are lower in the CSF of PD patients and those with related synucleinopathies compared to controls, its role in cognitive decline and dementia had been unexplored.

Prior studies have shown that levels of miR - 184 are unusually low in tissue samples from patients with malignant gliomas.

Hospitalized heart failure patients in all age groups within the study and with all levels of ejection fraction had significantly lower rates of survival after five years and a higher risk of re-hospitalization than people in the United States without heart failure.