"Pattern separation" means the brain's ability to distinguish and separate similar information or experiences, so that they can be stored as distinct memories.
Full definition
«Although running induces both substantial changes in number and morphology of young neurons as well as significant changes in learning behavior, this does not prove a causal relationship,» noted Professor Bischofberger, «Nevertheless, our results, together with previous findings, suggest that the
enhanced pattern separation during memory testing is most likely mediated via running - induced increase in adult neurogenesis.»
«Our research indicates that exercise - induced increase in neurogenesis
improves pattern separation by supporting unique and detailed long - term representations of similar but nevertheless different memory items.
In order to keep two similar memories separate, the hippocampus activates two different populations of neurons to encode each memory in a process
called pattern separation.
Investigators determined therefore that the running mice had developed
better pattern separation capabilities than sedentary mice.
These results imply a dual mechanism
for pattern separation in which signals from the entorhinal cortex can be decorrelated both by changes in coincidence patterns in the dentate gyrus and by recruitment of nonoverlapping cell assemblies in CA3.
Title: Dissociation between memory retention across a delay and
pattern separation following medial prefrontal cortex lesions in the touchscreen TUNL Task Author: K. A. L. McAllister et al..
Mice with increased neurogenesis had less overlap between the two populations of neurons and had more precise and stronger memories, which, according to Sahay, demonstrates
improved pattern separation.
Studies in mice have shown that suppressing neurogenesis can impair a type of learning
called pattern separation, which allows us to distinguish between two similar but slightly different circumstances.
Pattern separation is involved in many memory tasks of everyday life.
However, studies have shown that exercise can improve spatial navigation, contextual memory and the ability to distinguish between highly similar objects or stimuli (
pattern separation) in rodents and humans.
These results provide evidence that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of
pattern separation.
One crucial aspect of episodic memory is
pattern separation, the ability to retrieve the specifics of past events without generalizing to similar or partially overlapping events (Yassa and Stark, 2011).
Pattern separation and pattern completion in Alzheimer's disease: evidence of rapid forgetting in amnestic mild cognitive impairment.