Sentences with phrase «patterns of other genes»

The group also plans to look at methylation patterns of other genes in the serotonin system that may contribute to the brain's response to threatening stimuli.

Not exact matches

«While these findings are specific to HD and PD, these two diseases are sufficiently distinct to suggest that the observed pattern of differential gene activity may likely be observed in other neurodegenerative diseases of the central nervous system, including Alzheimer's disease and Chronic Traumatic Encephalophathy (CTE).»

«Phenocopy can be caused by other risk - modifying genes or exposure patterns that increase the probability of the specific phenotype manifesting itself,» says the study's first author Hildur Helgadottir, researcher at Karolinska Institutet's Department of Oncology - Pathology, Stockholm, Sweden.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

Yamanaka's group and two others followed up earlier this year with firmer evidence that these induced pluripotent stem (iPS) cells faithfully mimicked the patterns of gene activity and cellular differentiation observed in embryonic stem cells.

This pharyngeal gene cluster contains six genes ordered in a common pattern in all deuterostomes and includes the genes for four proteins that are critical transcriptional regulators that control activation of numerous other genes.

Other researchers used new techniques «to compare patterns of gene expression, to determine what was stressing the bees,» said Berenbaum.

She and her colleagues propose that other replication inhibitors to fight cancer will also produce unique double strand break profiles, as gene expression patterns would dictate the locations of replication - transcription conflicts.

Bioinformatic approaches to the analysis of genetic variability and complex genotype - phenotype relationships will moreover include gene sequence and database analyses, measures of association of haplotypes / genotypes with phenotype, clustering procedures, neuronal networks, fuzzy and other techniques in pattern recognition, similarity measures for discrete patterns (e.g., gene sequences, structures, functions), logistic regression methods, and a spectrum of other techniques.

This changes, among other things, the pattern of genes controlled by STAT5 and the cells begin to divide uncontrollably resulting in a STAT5 - dependent leukemia.

Other characteristic patterns of variants included genes involved in immune system activity and the fat content of breast milk.

Furthermore, by comparing the patterns of change in humans and chimpanzees, it was revealed that HAR - associated schizophrenia genes were under stronger evolutionary selective pressure than other schizophrenia genes.

At the time, Martin Cohn, an evolutionary developmental biologist at the University of Florida in Gainesville, discovered snake embryos had a different pattern of activity of certain genes than other reptiles and that applying a growth factor could make those embryos start to grow limbs.

Based on data from Robinson and other people who had similar experiences, Newell has been able to identify a pattern of genes turned on in their immune cells that may predict whether someone could be able to become «tolerant.»

A dizzying number of genetic transcripts, proteins and other molecular players alternatively glom together or fall apart, turning on or tuning down countless patterns of gene expression that keep our cells, organs and bodies humming along with the Earth's daily rotations.

In multicellular organisms, functional duplicate copies of a gene can exist in a genome, but if their expression patterns do not overlap, their products are unable to compensate for each other if either gene is mutated.

Detecting this signal is not an easy task due to various technical and biological confounding factors, but together with Yael Baran and Noah Zaitlen we developed a sophisticated statistical method that finds genes where the pattern of monoallelic expression is consistent with imprinting and not with other processes.

The application of transgenesis and other genetic methods - in conjunction with total genome sequence and database information on gene expression patterns, morphological changes during development, and mutant phenotypes - should significantly enhance our ability to unravel the multilayered networks that control gene expression and differentiation.

Using novel gene - array technology to measure the extent of gene expression in thousands of genes simultaneously, this study shows that as humans diverged from their ape ancestors in the last five million years, genes for transcription factors — which control the expression of other genes — were four times as likely to have changed their own expression patterns as the genes they regulate.

Therefore, it is necessary to determine the expression patterns of VASA and other germ cell marker genes in monkeys, but only limited information is currently available [7], [13].

Nevertheless, sponges share key adhesion and signalling genes7, 8,9,10,11 with eumetazoans, as well as other genes important in body plan patterning such as developmental transcription factors12, 13,14,15; sponge embryos and larvae (Fig. 1) are readily comparable to those of other animals12, 16.

There are already well established databases within the consortium, the London Pain Database (LPD) and QUAST (DFNS, Germany): The LPD is used for datamining of functional genomics data to help identify individual genes and functional networks associated with chronic pain, QUAST on the other hand collects questionnaire data, clinical and neurophysiological findings and calculates valid clusters of phenotypes with different interaction patterns of sensory loss with and without different types of peripheral and central hyperalgesia based on QST (quantitative sensory testing) data.

This way it is possible to obtain and compare the expression pattern of genes in the FunGenES database to the expression profiles in other tissues, experimental settings, or different stem cells types.

Since there is a higher than 95 % chance that cluster assignments are accurate (Supplemental File S2), and our validation analysis shows that 90.7 % of the array expression patterns match the RNA analysis results using other techniques (e.g., Q - PCR), we estimate that more than 86 % of the genes in a cluster follow the corresponding average expression profile.

It has been demonstrated that the composition of the medium used for embryo culture has a profound effect on the methylation pattern in the resultant two - cell embryos [10], indicating that, in addition to imprinted genes, other epigenetic alterations may intensely modify gene expression.

Some of the genes regulate colour, some determine pattern and markings and others are modifier genes.

Color is actually governed by several sets of genes, some that produce the color itself, others that influence intensity, pattern, amount and distribution of white markings, or distribution of pigment on individual hairs.

Because the Merle gene is dominant over other color genes breeding a Merle parent with a non Merle parent will statically guarantee at least one puppy in a little of four or more will be born with a Merle patterned coat.

The most recessive version of K is ky; two copies of ky will allow another gene, A (agouti,) to express itself in a number of patterns commonly seen in other breeds, such as tan points.

The technologies include biomimicry (production of materials by imitating nature — such as solar panels in the pattern of a leaf), gene editing and genomics, nanotechnology, artificial intelligence, robotics, the internet of things (where embedded software enables cars, buildings and other inanimate objects to communicate), and 3D printing.

However, inferring dispersal capability from life history characteristics should be undertaken with caution, given that life history only partially explains the observed patterns of gene flow for other marine species [60], [61].