Sentences with phrase «pbux riboswitch»

Following an alternative strategy, she integrated the thermometer structure in the riboswitch.

Riboswitches detect if there is a surplus of a certain metabolic product in the cell, and they regulate the biosynthesis or intake of that substance, if necessary.

In the study, which was published in the journal Nucleic Acids Research, the biologists utilised so - called riboswitches, also called RNA switches, and RNA thermometers.

The riboswitch required, for example, a certain chemical substance in combination with a certain temperature.

After producing the xpt - pbuX switch, the RNA polymerase encounters this «pause site» on the DNA code and slows down, allowing the right amount of time for the riboswitch to refold.

A riboswitch is a short piece of RNA that can fold into different structures, depending on whether or not a small messenger molecule is binds to it.

In transcriptional riboswitches, these different structures signal the nearby RNA polymerase to continue producing RNA or to stop.

In their recent publication in eLife, the Schwalbe group and their collaborators released molecular structures of the xpt - pbuX riboswitch in the off - position after synthesis and in the on - position upon binding by the small messenger molecule guanine.

These «riboswitches,» as Breaker calls them, are apparently essential to the workings of the cell.

One such regulatory element, the riboswitch, has excited interest as a potential target for antibiotics.

Molecular biologist Ronald Breaker of Yale University and his colleagues unearthed these multitalented RNA molecules — a class he calls riboswitches — after wading through decades of scientific literature and puzzling over a handful of unsolved mysteries.

Riboswitches — so named because they meddle with the ribosome — are portions of specific mRNAs that bind to a metabolite.

At the meeting, Breaker reported on his eighth bacterial riboswitch, which will appear in Nature.

Dr. Pillai joined City of Hope as Postdoctoral Fellow in the Department of Molecular and Cellular Bilolgy, where he developed novel genomic methods to regulate alternative splicing using artificial riboswitch.