In rats,
peak plasma concentration was found 30 minutes after oral dosing.
Bioavailability determinations based on
the peak plasma concentration can be misleading, because drug elimination begins as soon as the drug enters the bloodstream.
The isocaloric high - protein diet led to no significant change in nadir plasma concentrations,
peak plasma concentrations, or AUC values for the 24 - h leptin profiles obtained during CRC2 compared with those obtained during visit CRC1.
Not exact matches
Havel et al (32) reported that substitution of carbohydrate for dietary fat increased the diurnal circulating leptin pulse amplitude (
peak minus nadir
plasma leptin
concentration).
Our data directly address this hypothesis because we observed a decrease in leptin pulse amplitude between visit CRC1 and visit CRC2 (decreased
peak minus nadir
plasma leptin
concentration and decreased AUC of the change in leptin) without a significant change in integrated circulating leptin
concentration (leptin AUC).
The
plasma drug
concentration increases with the extent of absorption; the
peak is reached when the drug elimination rate equals absorption rate.
The longer time needed to reach
peak plasma nitrate
concentrations after ingestion of rocket salad and spinach beverages may be related to their higher fiber content and the larger volume ingested (Supplemental Table 1), likely resulting in a slower gastric emptying (34).
Eating high GI meals before exercise may result in
plasma glucose
concentrations peaking before the onset of exercise and then hypoglycaemia occurring within the first 30 minutes of the exercise period.