Sentences with phrase «peak plasma concentrations»

The isocaloric high - protein diet led to no significant change in nadir plasma concentrations, peak plasma concentrations, or AUC values for the 24 - h leptin profiles obtained during CRC2 compared with those obtained during visit CRC1.

Bioavailability determinations based on the peak plasma concentration can be misleading, because drug elimination begins as soon as the drug enters the bloodstream.

In rats, peak plasma concentration was found 30 minutes after oral dosing.

Not exact matches

Havel et al (32) reported that substitution of carbohydrate for dietary fat increased the diurnal circulating leptin pulse amplitude (peak minus nadir plasma leptin concentration).

Our data directly address this hypothesis because we observed a decrease in leptin pulse amplitude between visit CRC1 and visit CRC2 (decreased peak minus nadir plasma leptin concentration and decreased AUC of the change in leptin) without a significant change in integrated circulating leptin concentration (leptin AUC).

The plasma drug concentration increases with the extent of absorption; the peak is reached when the drug elimination rate equals absorption rate.

The longer time needed to reach peak plasma nitrate concentrations after ingestion of rocket salad and spinach beverages may be related to their higher fiber content and the larger volume ingested (Supplemental Table 1), likely resulting in a slower gastric emptying (34).

Eating high GI meals before exercise may result in plasma glucose concentrations peaking before the onset of exercise and then hypoglycaemia occurring within the first 30 minutes of the exercise period.