Often this is done by placing an ad listing the names and perhaps
pedigrees of affected dogs or posting them on a breed discussion list or website.
Not exact matches
Pedigrees are evaluated carefully to lessen the risk
of doubling up on a carrier and potentially causing a situation that could produce
affected dogs.
The parents and full and half siblings
of an
affected dog should not be bred close on the
pedigree that produced it and should be bred to mates that do not have a family history
of iris coloboma.
(Example from the
pedigree: Half the sire's carrier risk is.0625 and half the dam's carrier risk is.0838, so the chance
of producing an
affected dog is.0625 x.0838 =.0052 or 0.52 %.)
First - step relatives
of affected dogs (parents, full and half siblings, and offspring) should be bred only to mates with
pedigrees as clear
of lymphoma as possible and who have no
affected close relatives.
If it is not known whether the individual in the
pedigree is
affected, then the carrier risk is one - half the sire's carrier risk plus one - half the dam's carrier risk, minus the
affected risk
of the
dog.
Experienced breeders who study their
dogs pedigree well, can often successfully breed double dapple doxies which do not have problems, as not all
of these
dogs are
affected, but the risk is there so not many tend to do this.
Analysis
of pedigrees from 4005 Bernese mountain
dogs with 50
affected dogs revealed a polygenic, recessive mode
of inheritance with a predisposition for males 7.
The major observation made from examining the
pedigree was that the vast majority
of affected dogs were born to healthy parents (143
affected dogs from 112 litters).
However, breeders and owners
of Golden do need to be aware that these conditions exist, so that they can limit the use
of mildly
affected dogs, close relatives
of affected dogs, or repeated producers
of these conditions, in
pedigrees.
The collecting
of,
pedigree data around the
affected dogs is being done from the published list in the Breed Supplement.
But without knowing about the
affected dogs in a
pedigree, breeders are doomed to continue breeding proven carriers and other close relatives, to the misfortune
of those who purchase puppies from these crosses.
However, in a general sense, the decision to test or not should include considerations such as: the seriousness
of the disease, the reliability
of the test, the prevalence
of the disease in the breed, and the presence
of affected or carrier
dogs in the vertical
pedigree.
Through this program, PWD owners and breeders contacted OptiGen to provide
pedigrees, eye exam reports and blood samples from EOPRA
affected dogs and their relatives to achieve a critical mass
of research material needed for a successful gene hunt.
After studying
pedigrees of today's Old English Sheepdogs, it would not be surprising to find
affected dogs from diverse backgrounds in America, England, Australia, Japan, or other countries.
To facilitate health research on genetic diseases
affecting Bernese Mountain
Dogs, the Berner - Garde Foundation (BGF) had a vision
of creating a repository
of DNA and tumor tissue that would augment the
pedigree and current medical information stored in the Berner - Garde Database.
Although the definitive mode
of inheritance is often difficult to estimate from
pedigrees due to missing phenotypes, our
pedigrees in all breeds suggest a strong genetic influence with multiple
affected dogs across generations and even within several litters.
Pedigree analysis
of nearly 300 Swedish vallhund
dogs, including 125
affected animals, indicates a clear genetic contribution (Fig. 5).
To facilitate health research on genetic diseases
affecting Bernese Mountain
Dogs, the Berner - Garde Foundation had a goal
of creating a repository
of DNA and tumor tissue that would augment the
pedigree and medical information stored in the Berner - Garde Database.
This
pedigree is composed
of nearly 300
dogs, including 125 animals
affected with the breed - specific retinopathy.